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Protein Overview: CLU1

General Information:
Name(s) found: CLU1 / YMR012W [SGD]
Description(s) found:
Found 26 descriptions.
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  • eIF3 component of unknown function; deletion causes defects in mitochondrial organization but not in growth or translation initiation, can rescue cytokinesis and mitochondrial organization defects of the Dictyostelium cluA- mutant [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 1277 amino acids

    Gene Ontology:
    Cellular Component: cytoplasm [IDALink to PubMed article]
    eukaryotic translation initiation factor 3 complex [IPILink to PubMed article]
    Biological Process: translational initiation [IPILink to PubMed article]
    mitochondrion organization [IMPLink to PubMed article]
    Molecular Function: molecular_function [ND]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSEKKEEVKN ATVKVTVKLP KEDNHSHNTK HLKKTQSSKN NDISFEIGKE SKIQTVLDVL  60
   61 AMIPSSKYLT NVGLKTIEGD SQLSDEMSIK EIVGEKSELK LQLILKPYSA REALKHVITV 120
  121 RDFIGFAQET SDGLSEFAIS TGSSFSSLPL GPIKERSKQE EKDEKSDPEE KKNTFKDVTD 180
  181 EEKLKFNEMV HEVFSSFKNS SINKLLTSES NIITPCVRSL SFAPYNPVPP FYRSKGHLFY 240
  241 LQIVTLEGES FYITAIPSGF YVNKSNSTKF DPSPKENTDE NAHSSLIYYS LFDLIASRSK 300
  301 KFISHVQAFE KKLSALDSTS YVRPSNTFLH KPWFVSSLPP NNPDYLRLQT AALDTTPERN 360
  361 FNDEFQAIKD LTTSTLQDRI EMERLFSKVV HEFSVTAASG AMSIFYSDFV AMNPESPTRD 420
  421 QIFLKDNIFY SYVSDVSGNY EGKGGDEAAI AASNQDLKTI NILNRLHMHE VRYLLTTVVE 480
  481 FAGRRILAQT PVPGLLATMG NKIVKDANTG EEVTEDFVND INVKYGLDEG LGKIVYDADF 540
  541 DSVLEKKFVK AFHLKKHKVN GTELAFSSQS KGIVGFDKRR YILDLANTYP LDINFARQNF 600
  601 DNIEETGNRY PHRQTLLRPE LVEKWWNNKV EKEGVEFEKA YEENLFSYNP DAYQVEGIED 660
  661 ANVDEMSNYL QKEVIPSVIQ DYLSGNLSTP YNGEHLADTL HKNGINMRYL GKIIELSQKE 720
  721 LDSQIVHYEQ NLKAVEQDNK EYEDWEKSYL QKIENMIKER QAKINKLVQE GKEVPKELTE 780
  781 DLKLNDEEIK KPTDGKPVVV AYDELVPLIK ISELEIVSRS LKHVLKDLSK DVPVFLVPSL 840
  841 VAYVFNMLVG INYNADPKPE PVDEFYPVNK CSFAKLTRSE LLEAVSKQAF LRFRHQLPSN 900
  901 WIEAYMENPF TLIRSVSYKF GIQLLNKEYF FTREQLESYK QSLDKKIRNK FVEPPTTFSL 960
  961 SDLTIIPRVK FSEYTSSVSE EFWAQGASMI NEDKQSALTL LAQSITVLED VNNILHPAVA1020
 1021 EKYLSLSAIY NKLALYPEAI AFCRKACTIY ERVSGIDSFE MMRALTNLAI LEFSNESPYN1080
 1081 ATVVYNRLAE ILKVYELPKI HHPAPTSIFN HLEQLALGVQ DTKLAIEVLG QLSSYVVELE1140
 1141 GKDSLAYGYT ESRLGNLFAA LKDFHRALEH ITVTQGIFTK QLGMNHTHSA QSRQWVNGLS1200
 1201 SLIMDLKQKK QLAQDQMSTT GSNSAGHKKT NHRQKKDDVK PELANKSVDE LLTFIEGDSS1260
 1261 NSKSKNKTNN KKKHGKK

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) CLU1 ECM29 GCN20 GEA2 ILV1 MAE1 MDN1 RPA135 RPB2 RPN2 SAM1 TUB3 YHR020W
    View Details Krogan NJ, et al. (2006) CLU1 YJL144W YNL234W
    View Details Gavin AC, et al. (2006) CLU1 KAP104 URA7
    View Details Gavin AC, et al. (2002) ACC1 ADA2 ADH1 ARO1 ARX1 ASC1 ATG9 AVO1 BEM2 BMH1 BMH2 BMS1 BRX1 BUD20 CCT8 CEG1 CET1 CIC1 CLU1 CPA2 CRM1 CRN1 CTR9 CYR1 CYS4 DBP10 DBP9 DCP2 DRS1 EBP2 ECM29 ERB1 FDH1 FKS1 FPR4 FUN12 FUN19 GCN1 GCN20 GCN5 GEA2 GFA1 GLT1 GUS1 HAS1 HCR1 HDA1 HEM13 HER1 HHF1, HHF2 HIS3 HRP1 HSC82 IDH2 ILV1 INP2 IPI1 IPI3 IST2 KAP104 KAP114 KAP123 KGD1 KGD2 KRE33 KTR5 LCB1 LCB2 LEA1 LHP1 LOC1 LPD1 LSG1 LSM12 LYS12 MAK21 MAK5 MDN1 MEC1 MED4 MES1 MET18 MIP6 MIR1 MIS1 MKT1 MNN4 MOT1 MRPL23 MRPL3 MRT4 MYO1 NAB2 NAB3 NAB6 NAP1 NGG1 NIP1 NIP7 NMD3 NOC2 NOC3 NOG1 NOG2 NOP1 NOP12 NOP15 NOP16 NOP2 NOP4 NOP56 NOP7 NRD1 NSA1 NSA2 NUG1 PDB1 PFK1 PFK2 PRP43 PRT1 PSA1 PSK1 PTC1 PUF6 RAD3 RAD51 RAD52 REI1 RFA1 RIC1 RIX1 RIX7 RLI1 RLP24 RLP7 ROM2 RPA135 RPA190 RPB2 RPF1 RPF2 RPG1 RPN10 RPN11 RPN12 RPN8 RPN9 RPO21 RPP2B RPT3 RPT5 RPT6 RRP1 RRP12 RSA3 RSA4 RTR1 RVB2 SAM1 SAM2 SDA1 SEC27 SEC7 SEN54 SGF29 SGF73 SIN3 SIN4 SKI2 SMC3 SNU13 SPB1 SPB4 SPT15 SPT16 SPT20 SPT5 SPT7 SPT8 SSA3 SSA4 SSF1 SUA7 SUI1 SUI2 SUI3 SUP35 SUP45 TAF1 TAF10 TAF11 TAF12 TAF13 TAF14 TAF2 TAF3 TAF4 TAF5 TAF6 TAF7 TAF8 TAF9 TAO3 TBF1 TCB1 TEF4 TFP1 TIF1, TIF2 TIF34 TIF35 TIF5 TIF6 TOP2 TSA1 TUB3 URA7 URB1 USO1 UTP10 UTP20 UTP22 UTP6 VAC14 VAS1 VPS1 VPS5 YDJ1 YGL036W YHB1 YHR020W YJL017W YMR31 YOL098C YTM1
    View Details Ho Y, et al. (2002) AAT2 ACH1 ACO1 ACS2 ADE3 ADE6 ADK1 ADO1 AFR1 AHA1 AHP1 AIM13 ALA1 APE2 ARA1 ARC1 ARF1 ARP2 ATP3 AVO1 BAT1 BFA1 BRX1 BUD13 BUD3 CAR2 CCT2 CCT3 CCT5 CCT6 CDC10 CDC11 CDC12 CDC15 CDC28 CDC3 CDC33 CFT1 CIC1 CIK1 CIN8 CLU1 COF1 COP1 COR1 CPR1 CYC8 CYR1 CYS3 CYS4 DED81 DHH1 DPB2 DPS1 DUG2 ECM10 EGD1 ERB1 ERG10 ERG13 ERG20 ERG6 FAA4 FAR1 FET3 FIN1 FIP1 FPR1 FPR3 FPR4 FRS2 FUN12 GAL7 GCY1 GLC7 GLC8 GND1 GND2 GPH1 GRS1 GRX1 GSY1 GUS1 HEF3 HER1 HHF1, HHF2 HIR1 HOM2 HTB1 HTB2 HYP2 IDH1 ILS1 ILV2 IMD3 INM1 KEL1 KIP3 KRE33 KRS1 LRO1 LSP1 MAM33 MDH3 MEC1 MET10 MET16 MET6 MGE1 MHP1 MKK2 MKT1 MNP1 NAN1 NOG2 NOP56 NPA3 NPL3 NSA1 NTF2 NTG1 NUP53 OLA1 OYE2 PAB1 PDI1 PDX1 PFK1 PFK2 PGM2 PHO85 PIL1 PMI40 POL5 PRB1 PRM2 PRP11 PRP6 PUB1 PUF3 RBG1 REG1 REX2 RFC2 RNR1 RNR2 RPC40 RPC82 RPN1 RPN12 RPT3 RRP12 RRP17 RSN1 RVB1 SAC6 SAH1 SCD5 SCP160 SDS22 SEC27 SEC53 SEN1 SEN15 SES1 SGN1 SHM2 SIS1 SLX1 SNU13 SOD1 SPB1 SPH1 SPT16 SPT2 SRP1 SRP54 SSD1 SSK2 SSY5 SSZ1 STI1 SUI2 SUI3 TCP1 TEF4 TEM1 TFC7 TFP1 THI22 THR4 THS1 TIF1, TIF2 TIF34 TIF4631 TIF4632 TMA19 TOP1 TOP2 TRR1 TSA2 TUP1 UBA1 UBP15 UFD4 UTP10 UTP13 UTP22 UTP7 VMA4 VMA5 VMA8 WTM1 YDL124W YDR266C YER077C YGR067C YGR250C YGR266W YKR051W YKU80 YLR271W YNK1 YPR003C YPR015C YTM1
    View Details Qiu et al. (2008) CLU1 NIP1 PRT1 RPG1 TIF34 TIF35

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run RPA135 No Comments Schneider, DA, et al. (2006)
    View Run ZDS1 Sample 2- cpn2 from june 2005 McCusker D, et al (2007)
    View Run BOI1 Sample bob1 (2nd set) from october 2005 McCusker D, et al (2007)
    View Run MLP2 #10 Mitotic Prep1-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data CLU1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..716] MSA 2.141852 View MSA. No confident structure predictions are available.
    2 View Details [717..802] deduced N/A No confident structure predictions are available.
    3 View Details [803..991] PSI-BLAST 30.69897 Peroxin pex5 (peroxisomal targeting signal 1 (PTS1) receptor)
    4 View Details [992..1076] PSI-BLAST 30.69897 Peroxin pex5 (peroxisomal targeting signal 1 (PTS1) receptor)
    5 View Details [1077..1154] PSI-BLAST 30.69897 Peroxin pex5 (peroxisomal targeting signal 1 (PTS1) receptor)
    6 View Details [1155..1277] PSI-BLAST 30.69897 Peroxin pex5 (peroxisomal targeting signal 1 (PTS1) receptor)

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • binding
    		•  1.58148987937399 bayes_pls_golite062009
  • protein binding
    		•  0.856276659140234 bayes_pls_golite062009
    3 No functions predicted.
    4 No functions predicted.
    5
    Term Confidence Notes
  • binding
    		•  2.07985546140154 bayes_pls_golite062009
  • protein binding
    		•  1.6279032205159 bayes_pls_golite062009
  • transcription regulator activity
    		•  0.921062221092247 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.75712113503301 bayes_pls_golite062009
  • DNA binding
    		•  0.665813461397509 bayes_pls_golite062009
    6 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.96

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle