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Protein Overview: TEM1

General Information:
Name(s) found: TEM1 / YML064C [SGD]
Description(s) found:
Found 32 descriptions.
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  • GTP-binding protein of the ras superfamily involved in termination of M-phase; controls actomyosin and septin dynamics during cytokinesis [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 245 amino acids

    Gene Ontology:
    Cellular Component: spindle pole body [TASLink to PubMed article]
    Biological Process: regulation of exit from mitosis [TASLink to PubMed article]
    Molecular Function: protein binding [IPILink to PubMed article]
    GTPase activity [ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MATPSTGANN SIPAVRNQVE VQVGLVGDAQ VGKTSLMVKY VQNIYDKEYT QTLGVNFLKR  60
   61 KVSIRSTDII FSIMDLGGQR EFINMLPIAT VGSSVIIFLF DLTRPETLSS IKEWYRQAYG 120
  121 LNDSAIPILV GTKYDLLIDL DPEYQEQISR TSMKYAQVMN APLIFCSTAK SINIQKIFKI 180
  181 ALAKIFNLTL TIPEINEIGD PLLIYKHLGG QQHRHHNKSQ DRKSHNIRKP SSSPSSKAPS 240
  241 PGVNT

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) CDC15 DUG2 TEM1
    View Details Krogan NJ, et al. (2006) BFA1 CDC48 DOA1 FBP1 MRM1 NDT80 NPL4 OTU1 RDS2 SHP1 TEM1 TUP1 UBX4 UBX5 UBX7 UFD1 UFD2 YDR049W YGL108C YJR098C YNL155W YOR342C
    View Details Ho Y, et al. (2002) ADK1 ATP3 AVO1 BFA1 CCT5 CDC15 CDC33 CLU1 COF1 COR1 CPR1 CPR3 CYS4 DHH1 DPB2 DUG2 DUT1 EFB1 FAA4 FUN12 GAL7 GCD11 GPH1 GUS1 HAS1 IDH1 ILV2 KGD1 MCX1 MET16 MKK2 NMD3 NOG2 NPA3 NUP53 PDX1 PFK1 PHO85 PST2 PUF3 RNR1 RNR2 RPN12 RVB1 SAR1 SEC53 SIS1 SLX1 SRP54 SSD1 STI1 TEF4 TEM1 TFC7 TIF1, TIF2 TMA29 UFD4 VMA5 VMA8 YER077C YGR066C YGR266W YHB1 YHR033W YKR051W YKU80 YLR271W YNK1 YPR003C YTM1
    View Details Qiu et al. (2008) ATG27 CDC14 HSK3 LCB3 MOB1 TEM1 VRP1

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run MLP2 #12 Mitotic Prep1-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #10 Mitotic Prep1-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)
    View Run MLP2 #11 Mitotic Prep1-TiO2 enriched, new search criteria Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen TEM1 SOR2 2 Uetz P, et al. (2000)
    View Screen TEM1 BIT61 2 Uetz P, et al. (2000)
    View Screen TEM1 MGS1 2 Uetz P, et al. (2000)
    View Screen TEM1 FOB1 2 Uetz P, et al. (2000)
    View Screen TEM1 NIF3 2 Unpublished Fields Lab Data
    View Screen TEM1 LAP3 2 Unpublished Fields Lab Data
    View Screen TEM1 KIN3 2 Uetz P, et al. (2000)
    View Screen TEM1 PRM3 2 Uetz P, et al. (2000)
    View Screen TEM1 HMO1 2 Uetz P, et al. (2000)
    View Screen TEM1 YJR056C 2 Uetz P, et al. (2000)
    View Screen TEM1 YBL112C, YHR218W-A 2 Unpublished Fields Lab Data
    View Screen TEM1 RRF1 2 Uetz P, et al. (2000)
    View Screen TEM1 ECI1 2 Uetz P, et al. (2000)
    View Screen TEM1 SNZ2 2 Uetz P, et al. (2000)
    View Screen TEM1 MNS1 2 Uetz P, et al. (2000)
    View Screen TEM1 SMX3 2 Uetz P, et al. (2000)
    View Screen TEM1 SEC66 2 Uetz P, et al. (2000)
    View Screen TEM1 EDC3 2 Uetz P, et al. (2000)
    View Screen TEM1 SOR1 2 Uetz P, et al. (2000)
    View Screen TEM1 PEX18 2 Unpublished Fields Lab Data
    View Screen TEM1 LAC1 2 Uetz P, et al. (2000)
    View Screen TEM1 AIM18 2 Uetz P, et al. (2000)
    View Screen TEM1 HSP10 2 Uetz P, et al. (2000)
    View Screen TEM1 DMC1 2 Uetz P, et al. (2000)
    View Screen TEM1 YCR087W 2 Uetz P, et al. (2000)
    View Screen TEM1 ATG16 2 Unpublished Fields Lab Data
    View Screen TEM1 WTM2 2 Uetz P, et al. (2000)
    View Screen TEM1 DIG1 2 Uetz P, et al. (2000)

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data TEM1 Huh WK, et al. (2003)
    View Data TEM1 and SPC42 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..245] PSI-BLAST 208.522879 Rab-related protein Sec4

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • microtubule motor activity
    		•  4.51968578934603 bayes_pls_golite062009
  • motor activity
    		•  4.04927796049806 bayes_pls_golite062009
  • transporter activity
    		•  3.10463051760206 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  2.95886887664984 bayes_pls_golite062009
  • nucleoside-triphosphatase activity
    		•  2.74389108884083 bayes_pls_golite062009
  • tubulin binding
    		•  2.67743463093593 bayes_pls_golite062009
  • pyrophosphatase activity
    		•  2.67097555143215 bayes_pls_golite062009
  • hydrolase activity
    		•  2.65461298232951 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides
    		•  2.65161658635465 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
    		•  2.64849912301318 bayes_pls_golite062009
  • binding
    		•  2.64537357529343 bayes_pls_golite062009
  • microtubule binding
    		•  2.59155206524122 bayes_pls_golite062009
  • microfilament motor activity
    		•  2.51786963027655 bayes_pls_golite062009
  • active transmembrane transporter activity
    		•  2.50494515048649 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  2.4101693596493 bayes_pls_golite062009
  • primary active transmembrane transporter activity
    		•  2.39629638016861 bayes_pls_golite062009
  • P-P-bond-hydrolysis-driven transmembrane transporter activity
    		•  2.39600931083427 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances
    		•  2.36051733655256 bayes_pls_golite062009
  • ATPase activity, coupled to movement of substances
    		•  2.35906629925754 bayes_pls_golite062009
  • ATPase activity, coupled to transmembrane movement of substances
    		•  2.35679406876731 bayes_pls_golite062009
  • actin binding
    		•  2.2973522188675 bayes_pls_golite062009
  • ATPase activity
    		•  2.2625504298178 bayes_pls_golite062009
  • ATPase activity, coupled
    		•  2.24901251684901 bayes_pls_golite062009
  • guanyl nucleotide binding
    		•  1.89320355239381 bayes_pls_golite062009
  • guanyl ribonucleotide binding
    		•  1.88721318481223 bayes_pls_golite062009
  • GTP binding
    		•  1.87900088157196 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.84541587592638 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  1.65609907941094 bayes_pls_golite062009
  • GTPase activity
    		•  1.6309422514633 bayes_pls_golite062009
  • DNA binding
    		•  1.48341220422804 bayes_pls_golite062009
  • plus-end-directed microtubule motor activity
    		•  1.38366133153678 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  1.3182108176243 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.30136714640988 bayes_pls_golite062009
  • actin filament binding
    		•  1.28204719195916 bayes_pls_golite062009
  • protein binding
    		•  1.22129154759482 bayes_pls_golite062009
  • catalytic activity
    		•  1.00104173493322 bayes_pls_golite062009
  • purine nucleotide binding
    		•  0.929901285538132 bayes_pls_golite062009
  • nucleotide binding
    		•  0.922442819194247 bayes_pls_golite062009
  • actin-dependent ATPase activity
    		•  0.92105578610354 bayes_pls_golite062009
  • purine ribonucleotide binding
    		•  0.920987930180051 bayes_pls_golite062009
  • ribonucleotide binding
    		•  0.920926158369519 bayes_pls_golite062009
  • ion transmembrane transporter activity
    		•  0.704934361725919 bayes_pls_golite062009
  • signal transducer activity
    		•  0.683309012097319 bayes_pls_golite062009
  • molecular transducer activity
    		•  0.683309012097319 bayes_pls_golite062009
  • ATP binding
    		•  0.41092997612902 bayes_pls_golite062009
  • adenyl ribonucleotide binding
    		•  0.385813421701492 bayes_pls_golite062009
  • adenyl nucleotide binding
    		•  0.377870145186619 bayes_pls_golite062009
  • transcription activator activity
    		•  0.374651542607188 bayes_pls_golite062009
  • transcription factor activity
    		•  0.341088753451767 bayes_pls_golite062009
  • cation transmembrane transporter activity
    		•  0.282397764628576 bayes_pls_golite062009
  • protein transporter activity
    		•  0.217249710833262 bayes_pls_golite062009
  • structural constituent of ribosome
    		•  0.208665086324262 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  0.106147926780353 bayes_pls_golite062009
  • structural constituent of cytoskeleton
    		•  0.0111338193708552 bayes_pls_golite062009


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle