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Protein Overview: SRP54

General Information:
Name(s) found: SRP54 / YPR088C [SGD]
Description(s) found:
Found 33 descriptions.
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  • Signal recognition particle (SRP) subunit (homolog of mammalian SRP54); contains the signal sequence-binding activity of SRP, interacts with the SRP RNA, and mediates binding of SRP to signal receptor; contains GTPase domain [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 541 amino acids

    Gene Ontology:
    Cellular Component: signal recognition particle, endoplasmic reticulum targeting [IDALink to PubMed article]
    Biological Process: SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition [ICLink to PubMed article]
    protein targeting to ER [IPILink to PubMed article]
    Molecular Function: signal sequence binding [IPILink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MVLADLGKRI NSAVNNAISN TQDDFTTSVD VMLKGIVTAL LESDVNIALV SKLRNNIRSQ  60
   61 LLSENRSEKS TTNAQTKKLI QKTVFDELCK LVTCEGSEEK AFVPKKRKTN IIMFVGLQGS 120
  121 GKTTSCTKLA VYYSKRGFKV GLVCADTFRA GAFDQLKQNA IRARIPFYGS YTETDPAKVA 180
  181 EEGINKFKKE KFDIIIVDTS GRHHQEEELF QEMIEISNVI KPNQTIMVLD ASIGQAAEQQ 240
  241 SKAFKESSDF GAIILTKMDG HARGGGAISA VAATNTPIIF IGTGEHIHDL EKFSPKSFIS 300
  301 KLLGIGDIES LFEQLQTVSN KEDAKATMEN IQKGKFTLLD FKKQMQTIMK MGPLSNIAQM 360
  361 IPGMSNMMNQ VGEEETSQKM KKMVYVLDSM TKEELESDGR MFIEEPTRMV RVAKGSGTSV 420
  421 FEVEMILMQQ QMMARMAQTA TQQQPGAPGA NARMPGMPNM PGMPNMPGMP NMPGMPKVTP 480
  481 QMMQQAQQKL KQNPGLMQNM MNMFGGGMGG GMGGGMPDMN EMMKMMQDPQ MQQMAKQFGM 540
  541 G

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) LHP1 SEC65 SRP14 SRP21 SRP54 SRP68 SRP72
    View Details (MIPS) Mewes HW, et al. (2004) SEC65 SRP14 SRP21 SRP54 SRP68 SRP72
    View Details Krogan NJ, et al. (2006) LHP1 SEC65 SRP14 SRP21 SRP54 SRP68 SRP72 YCR090C
    View Details Gavin AC, et al. (2006) SEC65 SRP14 SRP54 SRP68 SRP72
    View Details Gavin AC, et al. (2002) BEM2 LHP1 SEC65 SRO9 SRP14 SRP21 SRP54 SRP68 SRP72
    View Details Ho Y, et al. (2002) ATP3 AVO1 CAF4 CCT2 CCT3 CCT5 CCT6 CIC1 CLU1 DHH1 DPB2 ENT2 ERB1 FUN12 GAL7 GPH1 IDH1 ILV2 MET16 MKK2 NOG2 NPA3 OSH7 PDX1 PHO85 PUF3 RPF1 RPN12 SIS1 SLX1 SRP54 STI1 TCP1 TEM1 TFC7 TMA108 VMA8 VPS35 YBL029W YBR242W YER077C YGR266W YKR051W YKU80 YLR271W YPD1 YPR003C YTM1
    View Details Qiu et al. (2008) SEC65 SRP14 SRP21 SRP54 SRP68 SRP72

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run CEP3 sample cbf3 from feb 2005 Sandall S, et all (2006)
    View Run RPA135 No Comments Schneider, DA, et al. (2006)
    View Run MLP2 #32 Asynchronous Prep-No Phosphopeptide enrichment Keck JM, et al. (2011)
    View Run MLP2 #03 Alpha Factor Prep1-TiO2 Flowthrough Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..89] PSI-BLAST 655.228787 Signal sequence recognition protein Ffh; GTPase domain of the signal sequence recognition protein Ffh
    2 View Details [90..319] PSI-BLAST 655.228787 Signal sequence recognition protein Ffh; GTPase domain of the signal sequence recognition protein Ffh
    3 View Details [320..408] PSI-BLAST 165.10721 SRP54M
    4 View Details [409..541] PSI-BLAST 2.522879 Sec24


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.48

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle