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Protein Overview: SIS1

General Information:
Name(s) found: SIS1 / YNL007C [SGD]
Description(s) found:
Found 28 descriptions.
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  • Type II HSP40 co-chaperone that interacts with the HSP70 protein Ssa1p; not functionally redundant with Ydj1p due to due to substrate specificity; shares similarity with bacterial DnaJ proteins [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 352 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IEA]
    cytoplasm [IEA]
    cytosolic small ribosomal subunit [IDA]
    Biological Process: translational initiation [IMPLink to PubMed article]
    protein folding [IDALink to PubMed article][IMPLink to PubMed article]
    Molecular Function: unfolded protein binding [TASLink to PubMed article]
    chaperone regulator activity [IDALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MVKETKLYDL LGVSPSANEQ ELKKGYRKAA LKYHPDKPTG DTEKFKEISE AFEILNDPQK  60
   61 REIYDQYGLE AARSGGPSFG PGGPGGAGGA GGFPGGAGGF SGGHAFSNED AFNIFSQFFG 120
  121 GSSPFGGADD SGFSFSSYPS GGGAGMGGMP GGMGGMHGGM GGMPGGFRSA SSSPTYPEEE 180
  181 TVQVNLPVSL EDLFVGKKKS FKIGRKGPHG ASEKTQIDIQ LKPGWKAGTK ITYKNQGDYN 240
  241 PQTGRRKTLQ FVIQEKSHPN FKRDGDDLIY TLPLSFKESL LGFSKTIQTI DGRTLPLSRV 300
  301 QPVQPSQTST YPGQGMPTPK NPSQRGNLIV KYKVDYPISL NDAQKRAIDE NF

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Gavin AC, et al. (2002) CDC24 HSP42 SIS1
    View Details Ho Y, et al. (2002) AHA1 ARP2 ATP3 AVO1 BCK1 CBK1 CCT5 CDC53 CLU1 CPR6 DHH1 DPB2 EGD2 FOL2 FUN12 GAL7 GND1 GPH1 IDH1 ILV2 ILV5 IPP1 KIC1 KIN2 LHS1 LYS12 MET16 MET30 MET31 MET4 MKK2 MKT1 MOB2 NOG2 NPA3 OYE2 PDC6 PDX1 PHO85 PIL1 PMA1 PUF3 QCR2 RCN2 RPN12 RPN6 RPT3 RUB1 SEC28 SIS1 SKG3 SKP1 SLT2 SLX1 SMK1 SRP54 STI1 TAO3 TEF4 TEM1 TFC7 TIF1, TIF2 VMA6 VMA8 YER077C YGR266W YKR051W YKU80 YLR271W YPR003C

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run MLP2 #32 Asynchronous Prep-No Phosphopeptide enrichment Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data SIS1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..79] PSI-BLAST 188.221849 DnaJ chaperone, N-terminal (J) domain
    2 View Details [80..180] ORFEUS 7.38 No description for 1la5A was found.
    3 View Details [181..257] PSI-BLAST 937.512579 Heat shock protein 40 Sis1
    4 View Details [258..352] PSI-BLAST 937.512579 Heat shock protein 40 Sis1


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle