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Protein Overview: SMK1

General Information:
Name(s) found: SMK1 / YPR054W [SGD]
Description(s) found:
Found 27 descriptions.
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  • Middle sporulation-specific mitogen-activated protein kinase (MAPK) required for production of the outer spore wall layers; negatively regulates activity of the glucan synthase subunit Gsc2p [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 388 amino acids

    Gene Ontology:
    Cellular Component: mitochondrion [IDALink to PubMed articleLink to PubMed article]
    Biological Process: negative regulation of sporulation resulting in formation of a cellular spore [IGILink to PubMed article]
    protein amino acid phosphorylation [IDALink to PubMed article][IMPLink to PubMed article][ISSLink to PubMed article]
    ascospore wall assembly [IGILink to PubMed article][IMPLink to PubMed articleLink to PubMed article]
    Molecular Function: MAP kinase activity [IDALink to PubMed article][IMPLink to PubMed article][ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNCTLTDNTR AINVASNLGA PQQRTIFAKE RISIPGYYEI IQFLGKGAYG TVCSVKFKGR  60
   61 SPAARIAVKK ISNIFNKEIL LKRAIRELKF MNFFKGHKNI VNLIDLEIVT SSPYDGLYCY 120
  121 QELIDYDLAK VIHSSVQLSE FHIKYFLYQI LCGLKYIHSA DVIHRDLKPG NILCTLNGCL 180
  181 KICDFGLARG IHAGFFKCHS TVQPHITNYV ATRWYRAPEL LLSNQPYSKS VDIWAVGCIL 240
  241 AEFYARKPVF MGRDSMHQIF EIIKVLGTPD KDILIKFGTI KAWNLGKNSN NPVYKKIPWS 300
  301 NIFPFASHEA INLIESLLHW DSTHRLNVEQ AISHPFLNEV RKPDDEPVCL QGPFDFTYES 360
  361 ELNSMSKLRD YLVEEVKNFK TDLSSSSL

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Krogan NJ, et al. (2006) PGS1 SMK1 YAP7
    View Details Ho Y, et al. (2002) AHA1 ARP2 BCK1 BUD7 COR1 CPR6 EGD2 FOL2 GAL7 GND1 IDH1 ILV5 IPP1 KIC1 KIN2 LHS1 LYS12 MAE1 MKK2 MKT1 OYE2 PDC6 PIL1 PMA1 PRE3 QCR2 RCN2 RNR2 RPN6 RPT3 SIS1 SKG3 SLT2 SMK1 STI1 TIF1, TIF2

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..90]
    [103..123]
    [358..388]    		 PSI-BLAST 803.9897 MAP kinase Erk2
    2 View Details [91..102]
    [124..357]    		 PSI-BLAST 803.9897 MAP kinase Erk2


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.98

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle