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Protein Overview: PGS1

General Information:
Name(s) found: PGS1 / YCL004W [SGD]
Description(s) found:
Found 25 descriptions.
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  • Phosphatidylglycerolphosphate synthase, catalyzes the synthesis of phosphatidylglycerolphosphate from CDP-diacylglycerol and sn-glycerol 3-phosphate in the first committed and rate-limiting step of cardiolipin biosynthesis [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 521 amino acids

    Gene Ontology:
    Cellular Component: mitochondrion [IDALink to PubMed article]
    Biological Process: phospholipid biosynthetic process [IMPLink to PubMed article]
    Molecular Function: CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase activity [IMPLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTTRLLQLTR PHYRLLSLPL QKPFNIKRQM SAANPSPFGN YLNTITKSLQ QNLQTCFHFQ  60
   61 AKEIDIIESP SQFYDLLKTK ILNSQNRIFI ASLYLGKSET ELVDCISQAL TKNPKLKVSF 120
  121 LLDGLRGTRE LPSACSATLL SSLVAKYGSE RVDCRLYKTP AYHGWKKVLV PKRFNEGLGL 180
  181 QHMKIYGFDN EVILSGANLS NDYFTNRQDR YYLFKSRNFS NYYFKLHQLI SSFSYQIIKP 240
  241 MVDGSINIIW PDSNPTVEPT KNKRLFLREA SQLLDGFLKS SKQSLPITAV GQFSTLVYPI 300
  301 SQFTPLFPKY NDKSTEKRTI LSLLSTITSN AISWTFTAGY FNILPDIKAK LLATPVAEAN 360
  361 VITASPFANG FYQSKGVSSN LPGAYLYLSK KFLQDVCRYR QDHAITLREW QRGVVNKPNG 420
  421 WSYHAKGIWL SARDKNDANN WKPFITVIGS SNYTRRAYSL DLESNALIIT RDEELRKKMK 480
  481 AELDNLLQYT KPVTLEDFQS DPERHVGTGV KIATSILGKK L

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Krogan NJ, et al. (2006) PGS1 SMK1 YAP7

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run BIR1 No Comments Widlund PO, et al. (2005)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..68] MSA 1.113983 View MSA. No confident structure predictions are available.
    2 View Details [69..521] PSI-BLAST 9.221849 Phospholipase D

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • binding
    		•  1.42274246180183 bayes_pls_golite062009
  • catalytic activity
    		•  1.29236214516383 bayes_pls_golite062009
  • phosphoric diester hydrolase activity
    		•  1.25148072945538 bayes_pls_golite062009
  • phosphoric ester hydrolase activity
    		•  0.97354820978871 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.566950403258922 bayes_pls_golite062009
  • protein binding
    		•  0.438178121330569 bayes_pls_golite062009
  • transferase activity
    		•  0.417847571627092 bayes_pls_golite062009
  • kinase activity
    		•  0.41582825017763 bayes_pls_golite062009
  • DNA binding
    		•  0.402372477477629 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  0.398900256450913 bayes_pls_golite062009


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.91

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle