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Protein Overview: BIR1

General Information:
Name(s) found: BIR1 / YJR089W [SGD]
Description(s) found:
Found 33 descriptions.
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  • Subunit of chromosomal passenger complex (CPC; Ipl1p-Sli15p-Bir1p-Nbl1p), which regulates chromosome segregation; required for chromosome bi-orientation and for spindle assembly checkpoint activation upon reduced sister kinetochore tension [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 954 amino acids

    Gene Ontology:
    Cellular Component: spindle midzone [IDALink to PubMed article]
    mitochondrion [IDALink to PubMed articleLink to PubMed article]
    spindle [IDALink to PubMed article]
    condensed nuclear chromosome kinetochore [IGILink to PubMed article][IPILink to PubMed article]
    Biological Process: mitotic spindle elongation [IMPLink to PubMed article]
    chromosome segregation [IMPLink to PubMed article]
    Molecular Function: molecular_function [ND]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDGQIDKMEK RYSMTKLENR LRTFQDGVAL EKKKLKWSFK VIPYQAMAKL GFYFDPVIDP  60
   61 KTSKLKKDSV RCCYCHRQTY NVRDCRSKRK DVLETLSNIM RQHLTVTDNK QVCLLIYLRN 120
  121 KLLTDYSFHM GVSDWKNDKY FSNPDDENVI NLRKFTFQDN WPHSGSQNEH PLGIEKMVNA 180
  181 GLMRYDSSIE GLGDPSMDKT LMNDTCYCIY CKQLLQGWSI NDDPMSRHYK VSQNGNCYFF 240
  241 QTRNRFERIK NDNDSITKNC EVSPTLGENG KREVINTKTA SQRQCPLFES PPSSTGPQLD 300
  301 DYNEKTDISV IQHNISVLDG AQGENVKRNS VEEKEQINME NGSTTLEEGN INRDVLADKK 360
  361 EVISTPTAKE IKRPNVQLTQ SSSPIKKKRK FKRISPRKIF DEEDSEHSLN NNSANGDNKD 420
  421 KDLVIDFTSH IIKNRDVGRK NAILDDSTDE FSFSNQGHNT FDIPIPTSSH LLKGIDSDND 480
  481 NVIREDDTGI NTDTKGASSK HEKFSVNSEE DLNFSEVKLT GRDSSTNILI RTQIVDQNLG 540
  541 DIDRDKVPNG GSPEVPKTHE LIRDNSEKRE AQNGEFRHQK DSTVRQSPDI LHSNKSGDNS 600
  601 SNITAIPKEE QRRGNSKTSS IPADIHPKPR KNLQEPRSLS ISGKVVPTER KLDNINIDLN 660
  661 FSASDFSPSS QSEQSSKSSS VISTPVASPK INLTRSLHAV KELSGLKKET DDGKYFTNKQ 720
  721 ETIKILEDVS VKNETPNNEM LLFETGTPIA SQENKSRKLF DEEFSGKELD IPIDSSTVEI 780
  781 KKVIKPEFEP VPSVARNLVS GTSSYPRNSR LEEQRKETST SLADNSKKGS SFNEGNNEKE 840
  841 PNAAEWFKID ENRHLVKNYF HDLLKYINNN DATLANDKDG DLAFLIKQMP AEELDMTFNN 900
  901 WVNLKVQSIK REFIDDCDKK LDILRRDYYT ATNFIETLED DNQLIDIAKK MGIL

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Krogan NJ, et al. (2006) BIR1 SLI15
    View Details Ho Y, et al. (2002) BFR2 BIR1 BNA5 CDC7 ECM10 JIP3 NUT1 PDC5 PDC6 PST2 RPC19 SAR1 SEC27 STI1 THI3 TPS1 UBI4 VAC14
    View Details Qiu et al. (2008) BIR1 HSK3 TID3

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run SLI15 No Comments Cheeseman IM, et al. (2002)
    View Run BIR1 No Comments Widlund PO, et al. (2005)
    View Run BIR1 No Comments Widlund PO, et al. (2005)
    View Run BIR1 No Comments Widlund PO, et al. (2005)
    View Run BIR1 No Comments Widlund PO, et al. (2005)
    View Run BIR1 sample bir 1 from feb 2005 Sandall S, et all (2006)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data BIR1 and SPC42 Huh WK, et al. (2003)
    View Data BIR1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..128] Pfam 15.259637 Inhibitor of Apoptosis domain No confident structure predictions are available.
    2 View Details [129..280] ORFEUS 14.83 Anti-apoptotic protein survivin
    3 View Details [281..635] MSA 6.164997 View MSA. No confident structure predictions are available.
    4 View Details [636..737] deduced N/A No confident structure predictions are available.
    5 View Details [738..954] MSA 1.018964 View MSA. No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • tubulin binding
    		•  4.57400254300037 bayes_pls_golite062009
  • microtubule binding
    		•  4.57357620081095 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  3.48621854589316 bayes_pls_golite062009
  • binding
    		•  2.74298177825814 bayes_pls_golite062009
  • protein binding
    		•  1.64791933694023 bayes_pls_golite062009
  • caspase inhibitor activity
    		•  1.09294960695843 bayes_pls_golite062009
  • caspase regulator activity
    		•  0.942292562752374 bayes_pls_golite062009
  • cysteine-type endopeptidase inhibitor activity
    		•  0.583383774635169 bayes_pls_golite062009
  • ubiquitin-protein ligase activity
    		•  0.395686831458354 bayes_pls_golite062009
  • small conjugating protein ligase activity
    		•  0.317066727620117 bayes_pls_golite062009
    2 No functions predicted.
    3 No functions predicted.
    4 No functions predicted.
    5 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle