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Protein Overview: HSK3

General Information:
Name(s) found: HSK3 / YKL138C-A [SGD]
Description(s) found:
Found 20 descriptions.
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  • Essential subunit of the Dam1 complex (aka DASH complex), couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; is transferred to the kinetochore prior to mitosis [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 69 amino acids

    Gene Ontology:
    Cellular Component: DASH complex [IDALink to PubMed articleLink to PubMed article][IPILink to PubMed articleLink to PubMed articleLink to PubMed article]
    spindle [IDALink to PubMed article]
    kinetochore [IPILink to PubMed article]
    Biological Process: mitotic spindle organization in nucleus [IMPLink to PubMed article]
    regulation of microtubule polymerization or depolymerization [IDALink to PubMed article][IPILink to PubMed article]
    Molecular Function: protein binding [IDALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNANKQRQYN QLAHELRELQ TNLQETTKQL DIMSKQCNEN LVGQLGKVHG SWLIGSYIYY  60
   61 MEQMLGKTQ

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) DUO1 HSK3 SPC19 SPC34
    View Details Krogan NJ, et al. (2006) ASK1 DAD1 DAD4 DAM1 DUO1 HSK3 NCA2 SPC19 SPC34
    View Details Qiu et al. (2008) AIP1 ARP1 ARP10 ASE1 ASK1 BIK1 BIM1 BIR1 BNI1 BRN1 BSP1 BUB1 BUB3 CAP2 CEP3 CIK1 CIN8 CMD1 CSE4 DAD1 DAD2 DAD3 DAD4 DAM1 DMC1 DUO1 DYN2 FPR4 HSK3 IPL1 IQG1 KAR1 KAR3 KIP2 KIP3 MAD2 MHP1 MIF2 MND1 MYO2 NBP1 NIP100 NUF2 PCC1 PEA2 PPH22 REC102 REC8 RED1 SFI1 SGO1 SKP1 SMC2 SMC4 SPC19 SPC29 SPC34 SPC42 SPC98 SPO13 STU2 TEM1 TID3 TPM2 TUB3 TWF1 ZIP1

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run DAD1 Dam1 complex purified from yeast with Dad1-TAP Shimogawa MM, et al. (2006)
    View Run DAD1 Dam1-765 complex purified from yeast with Dad1-TAP Shimogawa MM, et al. (2006)
    View Run DAD1 Dam1-765 complex purified from yeast with Dad1-TAP Shimogawa MM, et al. (2006)
    View Run DAD1 Dam1 complex purified from yeast with Dad1-TAP Shimogawa MM, et al. (2006)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..69] deduced N/A No confident structure predictions are available.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.95

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle