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Protein Overview: SMC2

General Information:
Name(s) found: SMC2 / YFR031C [SGD]
Description(s) found:
Found 27 descriptions.
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  • Subunit of the condensin complex; essential SMC chromosomal ATPase family member that forms a complex with Smc4p to form the active ATPase; Smc2p/Smc4p complex binds DNA; required for clustering of tRNA genes at the nucleolus [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 1170 amino acids

    Gene Ontology:
    Cellular Component: mitochondrion [IDALink to PubMed articleLink to PubMed article]
    nuclear condensin complex [IPILink to PubMed article][ISSLink to PubMed article][TASLink to PubMed articleLink to PubMed article]
    Biological Process: mitotic chromosome condensation [IMPLink to PubMed articleLink to PubMed article][TASLink to PubMed article]
    mitotic sister chromatid segregation [TASLink to PubMed article]
    Molecular Function: ATPase activity [IDALink to PubMed article]
    double-stranded DNA binding [IDALink to PubMed article]
    DNA secondary structure binding [IDALink to PubMed article]
    AT DNA binding [IDALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKVEELIIDG FKSYATRTVI TDWDPQFNAI TGLNGSGKSN ILDAICFVLG IASMSTVRAS  60
   61 SLQDLIYKRG QAGVTKASVT IVFDNTDKSN SPIGFTNSPQ ISVTRQVVLG GTSKYLINGH 120
  121 RAPQQSVLQL FQSVQLNINN PNFLIMQGKI TKVLNMKPSE ILSLIEEAAG TKMFEDRREK 180
  181 AERTMSKKET KLQENRTLLT EEIEPKLEKL RNEKRMFLEF QSTQTDLEKT ERIVVSYEYY 240
  241 NIKHKHTSIR ETLENGETRM KMLNEFVKKT SEEIDSLNED VEEIKLQKEK ELHKEGTISK 300
  301 LENKENGLLN EISRLKTSLS IKVENLNDTT EKSKALESEI ASSSAKLIEK KSAYANTEKD 360
  361 YKMVQEQLSK QRDLYKRKEE LVSTLTTGIS STGAADGGYN AQLAKAKTEL NEVSLAIKKS 420
  421 SMKMELLKKE LLTIEPKLKE ATKDNELNVK HVKQCQETCD KLRARLVEYG FDPSRIKDLK 480
  481 QREDKLKSHY YQTCKNSEYL KRRVTNLEFN YTKPYPNFEA SFVHGVVGQL FQIDNDNIRY 540
  541 ATALQTCAGG RLFNVVVQDS QTATQLLERG RLRKRVTIIP LDKIYTRPIS SQVLDLAKKI 600
  601 APGKVELAIN LIRFDESITK AMEFIFGNSL ICEDPETAKK ITFHPKIRAR SITLQGDVYD 660
  661 PEGTLSGGSR NTSESLLVDI QKYNQIQKQI ETIQADLNHV TEELQTQYAT SQKTKTIQSD 720
  721 LNLSLHKLDL AKRNLDANPS SQIIARNEEI LRDIGECENE IKTKQMSLKK CQEEVSTIEK 780
  781 DMKEYDSDKG SKLNELKKEL KLLAKELEEQ ESESERKYDL FQNLELETEQ LSSELDSNKT 840
  841 LLHNHLKSIE SLKLENSDLE GKIRGVEDDL VTVQTELNEE KKRLMDIDDE LNELETLIKK 900
  901 KQDEKKSSEL ELQKLVHDLN KYKSNTNNME KIIEDLRQKH EFLEDFDLVR NIVKQNEGID 960
  961 LDTYRERSKQ LNEKFQELRK KVNPNIMNMI ENVEKKEAAL KTMIKTIEKD KMKIQETISK1020
 1021 LNEYKRETLV KTWEKVTLDF GNIFADLLPN SFAKLVPCEG KDVTQGLEVK VKLGNIWKES1080
 1081 LIELSGGQRS LIALSLIMAL LQFRPAPMYI LDEVDAALDL SHTQNIGHLI KTRFKGSQFI1140
 1141 VVSLKEGMFA NANRVFRTRF QDGTSVVSIM

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) BRN1 SMC2 SMC4 YCS4
    View Details Krogan NJ, et al. (2006) BRN1 HIS2 SMC2 SMC4 YCG1 YCS4
    View Details Qiu et al. (2008) BRN1 HSK3 RIF1 SMC2 YCG1 YCS4

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run CEP3 sample cbf3 from feb 2005 Sandall S, et all (2006)
    View Run MLP2 #29 Asynchronous Prep5-TiO2 Flowthrough Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data SMC2 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..213] PSI-BLAST 9.69897 Rad50
    2 View Details [214..282] PSI-BLAST 9.69897 Tropomyosin
    3 View Details [283..364] PSI-BLAST 9.69897 Tropomyosin
    4 View Details [365..426] PSI-BLAST 9.69897 Tropomyosin
    5 View Details [427..487] PSI-BLAST 9.69897 Tropomyosin
    6 View Details [488..529]
    [553..583]    		 PSI-BLAST 83.06601 Smc hinge domain
    7 View Details [530..552]
    [584..587]
    [609..627]
    [670..687]    		 PSI-BLAST 83.06601 Smc hinge domain
    8 View Details [588..608]
    [628..669]    		 PSI-BLAST 83.06601 Smc hinge domain
    9 View Details [688..981] PSI-BLAST 50.9691 Heavy meromyosin subfragment
    10 View Details [982..1170] PSI-BLAST 157.68867 Smc head domain

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • binding
    		•  2.87991790206998 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  2.16596178759795 bayes_pls_golite062009
  • transcription regulator activity
    		•  2.122580758085 bayes_pls_golite062009
  • DNA binding
    		•  1.98453325263719 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.93681952439958 bayes_pls_golite062009
  • chromatin binding
    		•  1.68308196781423 bayes_pls_golite062009
  • transcription factor activity
    		•  1.36872096268289 bayes_pls_golite062009
  • transcription factor binding
    		•  1.23930219500076 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  1.14048290764066 bayes_pls_golite062009
  • centromeric DNA binding
    		•  1.13545283098583 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  1.09150919349912 bayes_pls_golite062009
  • protein binding
    		•  1.03780839342631 bayes_pls_golite062009
  • transcription cofactor activity
    		•  0.69917765277148 bayes_pls_golite062009
  • actin binding
    		•  0.618026108235131 bayes_pls_golite062009
  • DNA-dependent ATPase activity
    		•  0.526073636025138 bayes_pls_golite062009
  • telomeric DNA binding
    		•  0.284650049512347 bayes_pls_golite062009
  • transcription activator activity
    		•  0.174325083775401 bayes_pls_golite062009
  • histone binding
    		•  0.0391625783266718 bayes_pls_golite062009
    3 No functions predicted.
    4
    Term Confidence Notes
  • binding
    		•  2.87197012801422 bayes_pls_golite062009
  • protein binding
    		•  1.29499816770808 bayes_pls_golite062009
  • protein heterodimerization activity
    		•  0.82893422872344 bayes_pls_golite062009
  • structure-specific DNA binding
    		•  0.655291890141256 bayes_pls_golite062009
  • DNA secondary structure binding
    		•  0.597643104953011 bayes_pls_golite062009
  • protein dimerization activity
    		•  0.442459446636259 bayes_pls_golite062009
  • nucleoside-triphosphatase activity
    		•  0.340360347691162 bayes_pls_golite062009
  • pyrophosphatase activity
    		•  0.287295057420232 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides
    		•  0.273916899375488 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
    		•  0.271570433187831 bayes_pls_golite062009
  • double-stranded DNA binding
    		•  0.22807834114034 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  0.220174647358614 bayes_pls_golite062009
  • ATPase activity
    		•  0.142237490738159 bayes_pls_golite062009
    5 No functions predicted.
    6 No functions predicted.
    7 No functions predicted.
    8 No functions predicted.
    9 No functions predicted.
    10 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.84

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle