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Protein Overview: CEP3

General Information:
Name(s) found: CEP3 / YMR168C [SGD]
Description(s) found:
Found 27 descriptions.
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  • Essential kinetochore protein, component of the CBF3 complex that binds the CDEIII region of the centromere; contains an N-terminal Zn2Cys6 type zinc finger domain, a C-terminal acidic domain, and a putative coiled coil dimerization domain [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 608 amino acids

    Gene Ontology:
    Cellular Component: CBF3 complex [IDALink to PubMed articleLink to PubMed articleLink to PubMed article]
    condensed nuclear chromosome kinetochore [IDALink to PubMed article][TASLink to PubMed article]
    Biological Process: mitotic cell cycle spindle assembly checkpoint [IMPLink to PubMed article]
    Molecular Function: DNA bending activity [IDALink to PubMed article]
    centromeric DNA binding [IDALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MFNRTTQLKS KHPCSVCTRR KVKCDRMIPC GNCRKRGQDS ECMKSTKLIT ASSSKEYLPD  60
   61 LLLFWQNYEY WITNIGLYKT KQRDLTRTPA NLDTDTEECM FWMNYLQKDQ SFQLMNFAME 120
  121 NLGALYFGSI GDISELYLRV EQYWDRRADK NHSVDGKYWD ALIWSVFTMC IYYMPVEKLA 180
  181 EIFSVYPLHE YLGSNKRLNW EDGMQLVMCQ NFARCSLFQL KQCDFMAHPD IRLVQAYLIL 240
  241 ATTTFPYDEP LLANSLLTQC IHTFKNFHVD DFRPLLNDDP VESIAKVTLG RIFYRLCGCD 300
  301 YLQSGPRKPI ALHTEVSSLL QHAAYLQDLP NVDVYREENS TEVLYWKIIS LDRDLDQYLN 360
  361 KSSKPPLKTL DAIRRELDIF QYKVDSLEED FRSNNSRFQK FIALFQISTV SWKLFKMYLI 420
  421 YYDTADSLLK VIHYSKVIIS LIVNNFHAKS EFFNRHPMVM QTITRVVSFI SFYQIFVESA 480
  481 AVKQLLVDLT ELTANLPTIF GSKLDKLVYL TERLSKLKLL WDKVQLLDSG DSFYHPVFKI 540
  541 LQNDIKIIEL KNDEMFSLIK GLGSLVPLNK LRQESLLEEE DENNTEPSDF RTIVEEFQSE 600
  601 YNISDILS

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details (MIPS) Mewes HW, et al. (2004) CBF2 CEP3 CTF13 SKP1
    View Details Qiu et al. (2008) CBF2 CEP3 HSK3 SKP1

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run CEP3 sample cbf3 from feb 2005 Sandall S, et all (2006)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data CEP3 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..81] PSI-BLAST 24.071898 Hap1 (Cyp1); HAP1
    2 View Details [82..608] deduced N/A No confident structure predictions are available.
    3 View Details [194..362] deduced N/A No confident structure predictions are available.
    4 View Details [363..608] deduced N/A No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • binding
    		•  2.82809978070212 bayes_pls_golite062009
  • transcription regulator activity
    		•  2.56733746771213 bayes_pls_golite062009
  • DNA binding
    		•  2.39669003719518 bayes_pls_golite062009
  • nucleic acid binding
    		•  2.24073515120143 bayes_pls_golite062009
  • transcription factor activity
    		•  1.37656394138073 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  0.671744152078418 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  0.600827672357843 bayes_pls_golite062009
  • specific RNA polymerase II transcription factor activity
    		•  0.444119306269532 bayes_pls_golite062009
    2 No functions predicted.
    3 No functions predicted.
    4 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.90

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle