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Interacting selectively and non-covalently with a methylated cytosine/guanine dinucleotide. Interacting selectively and non-covalently with DNA sequences encoding transfer RNA. Interacting selectively and non-covalently with a telomere, a specific structure at the end of a linear chromosome required for the integrity and maintenance of the end. Interacting selectively and non-covalently with the regulatory region composed of the transcription start site and binding sites for transcription factor complexes of the basal transcription machinery. Interacting selectively and non-covalently with a centromere, a region of chromosome where the spindle fibers attach during mitosis and meiosis. Interacting selectively and non-covalently with the DNA replication origin, a unique DNA sequence of a replicon at which DNA replication is initiated and proceeds bidirectionally or unidirectionally. Interacting selectively and non-covalently with a 30-bp purine-rich negative regulatory element; the best characterized such element is found in the first intronic region of the rat cardiac alpha-myosin heavy chain gene, and contains two palindromic high-affinity Ets-binding sites (CTTCCCTGGAAG). The presence of this element restricts expression of the gene containing it to cardiac myocytes. Interacting selectively and non-covalently with any nucleic acid. Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). Interacting selectively and non-covalently with an enhancer, a cis-acting sequence that increases the utilization of some eukaryotic promoters, and can function in either orientation and in any location (upstream or downstream) relative to the promoter. Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. Interacting selectively and non-covalently with any P-element, a class of Drosophila transposon responsible for hybrid dysgenesis. Interacting selectively and non-covalently with unmethylated CpG motifs. Unmethylated CpG dinucleotides are often associated with gene promoters. Interacting selectively and non-covalently with replication fork barriers, sites that inhibit the progress of replication forks. Interacting selectively and non-covalently with oligo(A) and oligo(T) tracts of DNA (AT DNA). Interacting selectively and non-covalently with satellite DNA, the many tandem repeats (identical or related) of a short basic repeating unit; many have a base composition or other property different from the genome average that allows them to be separated from the bulk (main band) genomic DNA. Interacting selectively and non-covalently with DNA sequences encoding ribosomal RNA.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: sequence-specific DNA binding
Acc: GO:0043565
Aspect: Molecular Function
Desc: Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding.
Synonyms:
  • sequence specific DNA binding
Proteins in PDR annotated with:
   This term: 2739 [Search]
   Term or descendants: 3100 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0043565 - sequence-specific DNA binding (interactive image map)
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle