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Protein Overview: MLP2

General Information:
Name(s) found: MLP2 / YIL149C [SGD]
Description(s) found:
Found 24 descriptions.
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  • Myosin-like protein associated with the nuclear envelope, connects the nuclear pore complex with the nuclear interior; involved in the Tel1p pathway that controls telomere length [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 1679 amino acids

    Gene Ontology:
    Cellular Component: nuclear envelope [IDALink to PubMed article]
    ribonucleoprotein complex [IPILink to PubMed article]
    mitochondrion [IDALink to PubMed articleLink to PubMed article]
    nucleoplasm [IDALink to PubMed article]
    Biological Process: mRNA export from nucleus [IGILink to PubMed article][IPILink to PubMed article]
    protein import into nucleus [IGILink to PubMed article]
    regulation of transcription [IEPLink to PubMed article][IGILink to PubMed article]
    Molecular Function: ribonucleoprotein binding [IGILink to PubMed article][IPILink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MEDKISEFLN VPFESLQGVT YPVLRKLYKK IAKFERSEEE VTKLNVLVDE IKSQYYSRIS  60
   61 KLKQLLDESS EQKNTAKEEL NGLKDQLNEE RSRYRREIDA LKKQLHVSHE AMREVNDEKR 120
  121 VKEEYDIWQS RDQGNDSLND DLNKENKLLR RKLMEMENIL QRCKSNAISL QLKYDTSVQE 180
  181 KELMLQSKKL IEEKLSSFSK KTLTEEVTKS SHVENLEEKL YQMQSNYESV FTYNKFLLNQ 240
  241 NKQLSQSVEE KVLEMKNLKD TASVEKAEFS KEMTLQKNMN DLLRSQLTSL EKDCSLRAIE 300
  301 KNDDNSCRNP EHTDVIDELI DTKLRLEKSK NECQRLQNIV MDCTKEEEAT MTTSAVSPTV 360
  361 GKLFSDIKVL KRQLIKERNQ KFQLQNQLED FILELEHKTP ELISFKERTK SLEHELKRST 420
  421 ELLETVSLTK RKQEREITSL RQKINGCEAN IHSLVKQRLD LARQVKLLLL NTSAIQETAS 480
  481 PLSQDELISL RKILESSNIV NENDSQAIIT ERLVEFSNVN ELQEKNVELL NCIRILADKL 540
  541 ENYEGKQDKT LQKVENQTIK EAKDAIIELE NINAKMETRI NILLRERDSY KLLASTEENK 600
  601 ANTNSVTSME AAREKKIREL EAELSSTKVE NSAIIQNLRK ELLIYKKSQC KKKTTLEDFE 660
  661 NFKGLAKEKE RMLEEAIDHL KAELEKQKSW VPSYIHVEKE RASTELSQSR IKIKSLEYEI 720
  721 SKLKKETASF IPTKESLTRD FEQCCKEKKE LQMRLKESEI SHNENKMDFS SKEGQYKAKI 780
  781 KELENNLERL RSDLQSKIQE IESIRSCKDS QLKWAQNTID DTEMKMKSLL TELSNKETTI 840
  841 EKLSSEIENL DKELRKTKFQ YKFLDQNSDA STLEPTLRKE LEQIQVQLKD ANSQIQAYEE 900
  901 IISSNENALI ELKNELAKTK ENYDAKIELE KKEKWAREED LSRLRGELGE IRALQPKLKE 960
  961 GALHFVQQSE KLRNEVERIQ KMIEKIEKMS TIVQLCKKKE MSQYQSTMKE NKDLSELVIR1020
 1021 LEKDAADCQA ELTKTKSSLY SAQDLLDKHE RKWMEEKADY ERELISNIEQ TESLRVENSV1080
 1081 LIEKVDDTAA NNGDKDHLKL VSLFSNLRHE RNSLETKLTT CKRELAFVKQ KNDSLEKTIN1140
 1141 DLQRTQTLSE KEYQCSAVII DEFKDITKEV TQVNILKENN AILQKSLKNV TEKNREIYKQ1200
 1201 LNDRQEEISR LQRDLIQTKE QVSINSNKIL VYESEMEQCK QRYQDLSQQQ KDAQKKDIEK1260
 1261 LTNEISDLKG KLSSAENANA DLENKFNRLK KQAHEKLDAS KKQQAALTNE LNELKAIKDK1320
 1321 LEQDLHFENA KVIDLDTKLK AHELQSEDVS RDHEKDTYRT LMEEIESLKK ELQIFKTANS1380
 1381 SSDAFEKLKV NMEKEKDRII DERTKEFEKK LQETLNKSTS SEAEYSKDIE TLKKEWLKEY1440
 1441 EDETLRRIKE AEENLKKRIR LPSEERIQKI ISKRKEELEE EFRKKLKENA GSLTFLDNKG1500
 1501 SGEDAEEELW NSPSKGNSER PSAVAGFINQ KNLKPQEQLK NVKNDVSFND SQSMVTNKEN1560
 1561 NIVDSSAAGN KAIPTFSFGK PFFSSNTSSL QSFQNPFTAS QSNINTNAPL RTLNIQPEVA1620
 1621 VKAAINFSNV TDLTNNSTDG AKITEIGSTS KRPIESGTSS DPDTKKVKES PANDQASNE

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Krogan NJ, et al. (2006) BYE1 MLP2 NOC4 RIF1 TIF3
    View Details Ho Y, et al. (2002) ADE3 ALA1 FPR1 HOM3 ILV2 MLH3 MLP2 PFK2 SSZ1 TEP1 THS1 URA1 YDR341C
    View Details Qiu et al. (2008) KAP122 MAD1 MLP1 MLP2 PUF2 SAC3 SRP102 UTP6

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run PAN1 No Comments Toshima J, et al (2006)
    View Run CEP3 sample cbf3 from feb 2005 Sandall S, et all (2006)
    View Run ZDS1 Sample 2- cpn2 from june 2005 McCusker D, et al (2007)
    View Run BOI1 Sample boi 1 with ha tag from october 2005 McCusker D, et al (2007)
    View Run BOI1 Sample boi1 with gst from october 2005 McCusker D, et al (2007)
    View Run MLP2 #33 Asynchronous SPB prep Keck JM, et al. (2011)
    View Run MLP2 #19 Asynchronous Prep1-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)
    View Run MLP2 #20 Asynchronous Prep1-TiO2 Phosphopeptide enrichment, PartB Keck JM, et al. (2011)
    View Run MLP2 #25 Asynchronous Prep3-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #24 Asynchronous Prep3-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)
    View Run MLP2 #26 Asynchronous Prep4-TiO2 Phosphopeptide enriched, Steps1-2 Keck JM, et al. (2011)
    View Run MLP2 #21 Asynchronous Prep2-IMAC Phosphopeptide enrichment A1 Keck JM, et al. (2011)
    View Run MLP2 #22 Asynchronous Prep2-IMAC Phosphopeptide enrichment B1-2 Keck JM, et al. (2011)
    View Run MLP2 #34 Asynchronous SPB prep Keck JM, et al. (2011)
    View Run MLP2 #32 Asynchronous Prep-No Phosphopeptide enrichment Keck JM, et al. (2011)
    View Run MLP2 #35 Asynchronous SPB prep Keck JM, et al. (2011)
    View Run MLP2 #31 Asynchronous Prep (Protease cleavage) Keck JM, et al. (2011)
    View Run MLP2 #04 Alpha Factor Prep2 Keck JM, et al. (2011)
    View Run MLP2 #03 Alpha Factor Prep1-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #29 Asynchronous Prep5-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #14 Mitotic Prep2-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #13 Mitotic Prep2-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)
    View Run MLP2 #12 Mitotic Prep1-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #10 Mitotic Prep1-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)
    View Run MLP2 #02 Alpha Factor Prep1-TiO2 enriched, new search criteria Keck JM, et al. (2011)
    View Run MLP2 #30 Asynchronous Prep6-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)
    View Run MLP2 #11 Mitotic Prep1-TiO2 enriched, new search criteria Keck JM, et al. (2011)
    View Run MLP2 #01 Alpha factor Prep1-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)
    View Run MLP2 #28 Asynchronous Prep5-TiO2 Phosphopeptide Enrichment Keck JM, et al. (2011)
    View Run MLP2 #06 Alpha Factor Prep3-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)
    View Run MLP2 #08 Alpha Factor Prep4-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)
    View Run MLP2 #16 Mitotic-New search criteria Keck JM, et al. (2011)
    View Run MLP2 #15 Mitotic 2nd-TiO2 enriched, new search criteria Keck JM, et al. (2011)
    View Run MLP2 #19b Asynchronous Prep1-new search criteria Keck JM, et al. (2011)
    View Run MLP2 #05 Alpha Factor Prep2-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #07 Alpha Factor Prep3-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #09 Alpha Factor Prep4-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run None Entered #17 Mitotic Prep3-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)
    View Run None Entered #18 Mitotic Prep4-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)
    View Run MLP2 #19a Asynchronous Prep1-new search criteria Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen SPP382 MLP2 2 Hazbun TR, et al. (2003)

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data MLP2 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..175] MSA 1.465995 View MSA. No confident structure predictions are available.
    2 View Details [176..268] PSI-BLAST 9.522879 Tropomyosin
    3 View Details [269..692] PSI-BLAST 48.980454 Heavy meromyosin subfragment
    4 View Details [693..745] deduced N/A No confident structure predictions are available.
    5 View Details [746..1092] MSA 18.998997 View MSA. No confident structure predictions are available.
    6 View Details [1093..1169] deduced N/A Confident ab initio structure predictions are available.
    7 View Details [1170..1603] MSA 16.682998 View MSA. No confident structure predictions are available.
    8 View Details [1604..1679] deduced N/A No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3 No functions predicted.
    4 No functions predicted.
    5 No functions predicted.
    6
    Term Confidence Notes
  • transcription regulator activity
    		•  5.13863038737912 bayes_pls_golite062009
  • DNA binding
    		•  4.66369707598026 bayes_pls_golite062009
  • nucleic acid binding
    		•  4.20953772435302 bayes_pls_golite062009
  • transcription factor activity
    		•  4.06706589695599 bayes_pls_golite062009
  • binding
    		•  3.02779747447702 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  2.41271657675151 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  2.26183812259792 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  2.1457670954804 bayes_pls_golite062009
  • transcription repressor activity
    		•  1.91962622287073 bayes_pls_golite062009
  • transcription activator activity
    		•  1.77700860354597 bayes_pls_golite062009
  • actin binding
    		•  1.48871115327078 bayes_pls_golite062009
  • transcription factor binding
    		•  1.40653841901929 bayes_pls_golite062009
  • specific RNA polymerase II transcription factor activity
    		•  1.14886080629275 bayes_pls_golite062009
  • chromatin binding
    		•  0.876241359231159 bayes_pls_golite062009
  • transcription cofactor activity
    		•  0.84983974758882 bayes_pls_golite062009
  • protein binding
    		•  0.830419844171551 bayes_pls_golite062009
  • molecular transducer activity
    		•  0.515227322986114 bayes_pls_golite062009
  • signal transducer activity
    		•  0.515227322986114 bayes_pls_golite062009
  • general RNA polymerase II transcription factor activity
    		•  0.377270323657906 bayes_pls_golite062009
  • receptor activity
    		•  0.361249991204582 bayes_pls_golite062009
  • RNA binding
    		•  0.329588635205335 bayes_pls_golite062009
  • transcription coactivator activity
    		•  0.2679415219517 bayes_pls_golite062009
  • actin filament binding
    		•  0.26311995282891 bayes_pls_golite062009
  • transcription corepressor activity
    		•  0.25931464844298 bayes_pls_golite062009
  • transmembrane receptor activity
    		•  0.147724557486814 bayes_pls_golite062009
    7 No functions predicted.
    8 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle