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Protein Overview: ADE3

General Information:
Name(s) found: ADE3 / YGR204W [SGD]
Description(s) found:
Found 31 descriptions.
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  • Cytoplasmic trifunctional enzyme C1-tetrahydrofolate synthase, involved in single carbon metabolism and required for biosynthesis of purines, thymidylate, methionine, and histidine; null mutation causes auxotrophy for adenine and histidine [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 946 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDALink to PubMed article]
    cytoplasm [IDALink to PubMed articleLink to PubMed article]
    Biological Process: folic acid and derivative metabolic process [TAS]
    purine base biosynthetic process [IMPLink to PubMed article]
    Molecular Function: formate-tetrahydrofolate ligase activity [IMPLink to PubMed article][TASLink to PubMed article]
    methenyltetrahydrofolate cyclohydrolase activity [IMPLink to PubMed article]
    methylenetetrahydrofolate dehydrogenase (NADP+) activity [IMPLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAGQVLDGKA CAQQFRSNIA NEIKSIQGHV PGFAPNLAII QVGNRPDSAT YVRMKRKAAE  60
   61 EAGIVANFIH LDESATEFEV LRYVDQLNED PHTHGIIVQL PLPAHLDEDR ITSRVLAEKD 120
  121 VDGFGPTNIG ELNKKNGHPF FLPCTPKGII ELLHKANVTI EGSRSVVIGR SDIVGSPVAE 180
  181 LLKSLNSTVT ITHSKTRDIA SYLHDADIVV VAIGQPEFVK GEWFKPRDGT SSDKKTVVID 240
  241 VGTNYVADPS KKSGFKCVGD VEFNEAIKYV HLITPVPGGV GPMTVAMLMQ NTLIAAKRQM 300
  301 EESSKPLQIP PLPLKLLTPV PSDIDISRAQ QPKLINQLAQ ELGIYSHELE LYGHYKAKIS 360
  361 PKVIERLQTR QNGKYILVSG ITPTPLGEGK STTTMGLVQA LTAHLGKPAI ANVRQPSLGP 420
  421 TLGVKGGAAG GGYSQVIPMD EFNLHLTGDI HAIGAANNLL AAAIDTRMFH ETTQKNDATF 480
  481 YNRLVPRKNG KRKFTPSMQR RLNRLGIQKT NPDDLTPEEI NKFARLNIDP DTITIKRVVD 540
  541 INDRMLRQIT IGQAPTEKNH TRVTGFDITV ASELMAILAL SKDLRDMKER IGRVVVAADV 600
  601 NRSPVTVEDV GCTGALTALL RDAIKPNLMQ TLEGTPVLVH AGPFANISIG ASSVIADRVA 660
  661 LKLVGTEPEA KTEAGYVVTE AGFDFTMGGE RFFNIKCRSS GLTPNAVVLV ATVRALKSHG 720
  721 GAPDVKPGQP LPSAYTEENI EFVEKGAANM CKQIANIKQF GVPVVVAINK FETDTEGEIA 780
  781 AIRKAALEAG AFEAVTSNHW AEGGKGAIDL AKAVIEASNQ PVDFHFLYDV NSSVEDKLTT 840
  841 IVQKMYGGAA IDILPEAQRK IDMYKEQGFG NLPICIAKTQ YSLSHDATLK GVPTGFTFPI 900
  901 RDVRLSNGAG YLYALAAEIQ TIPGLATYAG YMAVEVDDDG EIDGLF

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Krogan NJ, et al. (2006) ADE3 MIS1 RPP1B TMA108
    View Details Gavin AC, et al. (2006) ADE3 CSE1 DPS1 SAR1 TDH1 TOM1 YDR341C YNK1
    View Details Gavin AC, et al. (2002) ADE3 ARX1 DBP2 LSG1 MIS1 NOG1 NOP7 NUG1 RAT1 SHM1 YPL009C
    View Details Ho Y, et al. (2002) ACS2 ADE3 ADE6 ADO1 ALA1 APE2 ARA1 BAT1 CDC10 CLU1 CYS3 DED81 DPS1 ERG10 ERG20 FPR1 GCY1 GPH1 GRS1 HOM2 HOM3 HYP2 ILS1 IMD3 KRS1 LSP1 MDH3 MLP2 OLA1 PAB1 PFK2 PGM2 PMI40 PRP6 SAC6 SCP160 SOD1 SSZ1 THR4 THS1 TRR1 UBA1 URA1 YDL124W YDR341C

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run RPA135 No Comments Schneider, DA, et al. (2006)
    View Run RLF2 phosphorylation data - cascade search Green EM, et al (2005)
    View Run ZDS1 Sample 2- cpn2 from june 2005 McCusker D, et al (2007)
    View Run BOI1 Sample boi 1 with ha tag from october 2005 McCusker D, et al (2007)
    View Run MLP2 #25 Asynchronous Prep3-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #32 Asynchronous Prep-No Phosphopeptide enrichment Keck JM, et al. (2011)
    View Run MLP2 #03 Alpha Factor Prep1-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #29 Asynchronous Prep5-TiO2 Flowthrough Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data ADE3 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..15]
    [127..286]    		 PSI-BLAST 848.9897 Methylenetetrahydrofolate dehydrogenase/cyclohydrolase; Tetrahydrofolate dehydrogenase/cyclohydrolase
    2 View Details [16..126]
    [287..313]    		 PSI-BLAST 848.9897 Methylenetetrahydrofolate dehydrogenase/cyclohydrolase; Tetrahydrofolate dehydrogenase/cyclohydrolase
    3 View Details [314..374]
    [393..678]
    [920..946]    		 PSI-BLAST 2400.0 Formyltetrahydrofolate synthetase
    4 View Details [375..392]
    [679..919]    		 PSI-BLAST 2400.0 Formyltetrahydrofolate synthetase

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • binding
    		•  2.64537357529343 bayes_pls_golite062009
  • nucleic acid binding
    		•  2.51683451033161 bayes_pls_golite062009
  • translation initiation factor activity
    		•  2.41232228963167 bayes_pls_golite062009
  • DNA binding
    		•  2.12258000781149 bayes_pls_golite062009
  • transcription regulator activity
    		•  2.09345198747025 bayes_pls_golite062009
  • lysine N-acetyltransferase activity
    		•  1.55478124277326 bayes_pls_golite062009
  • histone acetyltransferase activity
    		•  1.55478124277326 bayes_pls_golite062009
  • hydrolase activity
    		•  1.29060292615008 bayes_pls_golite062009
  • purine ribonucleotide binding
    		•  1.1110976601505 bayes_pls_golite062009
  • ribonucleotide binding
    		•  1.11103644113672 bayes_pls_golite062009
  • purine nucleotide binding
    		•  1.1086792521709 bayes_pls_golite062009
  • nucleotide binding
    		•  1.1060655022247 bayes_pls_golite062009
  • catalytic activity
    		•  1.00104173493322 bayes_pls_golite062009
  • transcription factor activity
    		•  0.887108427603557 bayes_pls_golite062009
  • hydrogen ion transmembrane transporter activity
    		•  0.854899277460172 bayes_pls_golite062009
  • RNA helicase activity
    		•  0.81256037545135 bayes_pls_golite062009
  • ATP binding
    		•  0.80197288940364 bayes_pls_golite062009
  • adenyl ribonucleotide binding
    		•  0.770085840885632 bayes_pls_golite062009
  • DNA-dependent ATPase activity
    		•  0.75383985982414 bayes_pls_golite062009
  • adenyl nucleotide binding
    		•  0.751575230566049 bayes_pls_golite062009
  • RNA-dependent ATPase activity
    		•  0.74918137191219 bayes_pls_golite062009
  • structural constituent of ribosome
    		•  0.738234102557832 bayes_pls_golite062009
  • monovalent inorganic cation transmembrane transporter activity
    		•  0.694120974355463 bayes_pls_golite062009
  • ATP-dependent RNA helicase activity
    		•  0.69117331267457 bayes_pls_golite062009
  • N-acyltransferase activity
    		•  0.581315571752634 bayes_pls_golite062009
  • N-acetyltransferase activity
    		•  0.487240078246257 bayes_pls_golite062009
  • kinase activity
    		•  0.431162005044036 bayes_pls_golite062009
  • ligase activity
    		•  0.417681194526243 bayes_pls_golite062009
  • inorganic cation transmembrane transporter activity
    		•  0.347619818489809 bayes_pls_golite062009
  • translation regulator activity
    		•  0.29096092258568 bayes_pls_golite062009
  • translation factor activity, nucleic acid binding
    		•  0.274994961137851 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  0.250756824614616 bayes_pls_golite062009
  • structure-specific DNA binding
    		•  0.229327589367146 bayes_pls_golite062009
  • acetyltransferase activity
    		•  0.190660928077915 bayes_pls_golite062009
  • protein binding
    		•  0.170837278876362 bayes_pls_golite062009
  • nucleobase, nucleoside, nucleotide kinase activity
    		•  0.12351419478929 bayes_pls_golite062009
  • helicase activity
    		•  0.0775311459068899 bayes_pls_golite062009
  • structural molecule activity
    		•  0.0558641287316701 bayes_pls_golite062009
  • RNA binding
    		•  0.0261282189186349 bayes_pls_golite062009
    3 No functions predicted.
    4 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.97

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle