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Protein Overview: RAT1

General Information:
Name(s) found: RAT1 / YOR048C [SGD]
Description(s) found:
Found 29 descriptions.
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  • Nuclear 5' to 3' single-stranded RNA exonuclease, involved in RNA metabolism, including rRNA and snRNA processing as well as poly (A+) dependent and independent mRNA transcription termination [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 1006 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDALink to PubMed article]
    mitochondrion [IDALink to PubMed articleLink to PubMed article]
    nuclear outer membrane [IMPLink to PubMed article]
    Biological Process: termination of RNA polymerase II transcription, poly(A)-coupled [IMPLink to PubMed article]
    RNA processing [IMPLink to PubMed article]
    Molecular Function: 5'-3' exoribonuclease activity [IDALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGVPSFFRWL SRKYPKIISP VLEEQPQIVD GVILPLDYSA SNPNGELDNL YLDMNGIVHP  60
   61 CSHPENKPPP ETEDEMLLAV FEYTNRVLNM ARPRKVLVMA VDGVAPRAKM NQQRARRFRS 120
  121 ARDAQIENEA REEIMRQREE VGEIIDDAVR NKKTWDSNAI TPGTPFMDKL AAALRYWTAF 180
  181 KLATDPGWKN LQVIISDATV PGEGEHKIMN FIRSQRADPE YNPNTTHCIY GLDADLIFLG 240
  241 LATHEPHFKI LREDVFAQDN RKRNNLKDTI NMTEEEKQFL QKQNSEQPFL WLHINVLREY 300
  301 LSAELWVPGL PFTFDLERAI DDWVFMCFFC GNDFLPHLPC LDVRENSIDI LLDIWKVVLP 360
  361 KLKTYMTCDG VLNLPSVETL LQHLGSREGD IFKTRHIQEA RKKEAFERRK AQKNMSKGQD 420
  421 RHPTVATEQL QMYDTQGNLA KGSWNLTTSD MVRLKKELML ANEGNEEAIA KVKQQSDKNN 480
  481 ELMKDISKEE IDDAVSKANK TNFNLAEVMK QKIINKKHRL EKDNEEEEIA KDSKKVKTEK 540
  541 AESECDLDAE IKDEIVADVN DRENSETTEV SRDSPVHSTV NVSEGPKNGV FDTDEFVKLF 600
  601 EPGYHERYYT AKFHVTPQDI EQLRKDMVKC YIEGVAWVLM YYYQGCASWN WFYPYHYAPL 660
  661 ATDFHGFSHL EIKFEEGTPF LPYEQLMSVL PAASGHALPK IFRSLMSEPD SEIIDFYPEE 720
  721 FPIDMNGKKM SWQGIALLPF IDQDRLLTAV RAQYPLLSDA ERARNIRGEP VLLISNKNAN 780
  781 YERFSKKLYS KENNNNNVVV KFQHFKSGLS GIVSKDVEGF ELNGKIVCPI QGGSLPNLST 840
  841 TLILKMSYRL IPLPSRNKSI ILNGFIPSEP VLTAYDLDSI MYKYNNQNYS RRWNFGNDLK 900
  901 QNIVPVGPKG ITQYKPRTGG YRAFFYFAEL SRNNVQPAHN YGRNSYNSQP GFNNSRYDGG 960
  961 NNNYRQNSNY RNNNYSGNRN SGQYSGNSYS RNNKQSRYDN SRANRR

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) RAI1 RAT1 RTT103
    View Details (MIPS) Mewes HW, et al. (2004) DRS1 GAR1 IFH1 NOP1 NPL3 NSR1 POP1 POP2 RAT1 RNT1 RRP3 SBP1 SNM1 SRD1 UTP10 UTP11 UTP13 UTP4 UTP5 UTP6 UTP7 UTP8 UTP9 YME2
    View Details Krogan NJ, et al. (2006) RAI1 RAT1 RTT103 YSP2
    View Details Gavin AC, et al. (2006) RAI1 RAT1
    View Details Gavin AC, et al. (2002) ADE3 ARX1 DBP2 LSG1 MIS1 NOG1 NOP7 NUG1 RAI1 RAT1 SHM1 SIT4 YPL009C
    View Details Qiu et al. (2008) DBP2 DBP7 DRS1 GAR1 NPL3 RAT1 RNT1

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run MLP2 #27 Asynchronous Prep4-TiO2 Phosphopeptide enriched, Steps3-5 Keck JM, et al. (2011)
    View Run MLP2 #03 Alpha Factor Prep1-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #29 Asynchronous Prep5-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #12 Mitotic Prep1-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #30 Asynchronous Prep6-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data RAT1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..271] Pfam 188.481486 XRN 5'-3' exonuclease N-terminus No confident structure predictions are available.
    2 View Details [272..678] deduced N/A No confident structure predictions are available.
    3 View Details [679..789] MSA 1.015973 View MSA. No confident structure predictions are available.
    4 View Details [790..880] deduced N/A No confident structure predictions are available.
    5 View Details [881..1006] MSA 2.012983 View MSA. No confident structure predictions are available.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle