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Protein Overview: UTP8

General Information:
Name(s) found: UTP8 / YGR128C [SGD]
Description(s) found:
Found 25 descriptions.
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  • Nucleolar protein required for export of tRNAs from the nucleus; also copurifies with the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 713 amino acids

    Gene Ontology:
    Cellular Component: small nucleolar ribonucleoprotein complex [IPILink to PubMed article]
    Biological Process: maturation of SSU-rRNA [IMPLink to PubMed article][IPILink to PubMed article]
    ribosome biogenesis [RCALink to PubMed article]
    Molecular Function: snoRNA binding [IPILink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPSLSQPFRL ATLPKIASLS NFSLQADYVQ VADGTFNEST NNITLGISGS SISQYIINPT  60
   61 PKLTFDYPIP STNIITACNA EKGQANIDGN IEASTDDEAN NEKTINTQKK RNVEIWAFGL 120
  121 MVNKGNYTLN VITKALEDTT DTSNDHLSES DIDNKAYTGS DEFLSQYKIK AKAKVMSIKI 180
  181 DTKNSLVIAI LQNGLIEIFD FKLTLLHSFD ISYDNLKYAK WFTENGTEYV FVLCPLQDDK 240
  241 VCYKLLELTD CGSGESSPIK ELSSTIIEGF SFENSKLCYQ FGKLYKLNQG KIYIYSLPHC 300
  301 QLQQVIEFPM VDKLSPGDDL ISFQPVSVNR VLLTVNNVIY LLDLLHCSTL SQRELTHVKT 360
  361 FQLLKSAVIN SEKSHNSKTI AIGISTKNGP NPTSSLEIIN IDVGTNTLKD SLGKSFQVGN 420
  421 NDSSVILKPL FDDKDINDKR VKCNDVSGDS SVPVLHCNEV IEKLSALQDN DITSFDDIFF 480
  481 KELKIKEEHY TEKDRYISDP GFLNKVLDLI FGKFSGNDYP KTLTFLLTHP LFPLSRTRNL 540
  541 LSLLRDQPRL FKQAIVTCPN LPLNELLEEL FSIRNRELLL DISFRILQDF TRDSIKQEMK 600
  601 KLSKLDVQNF IEFITSGGED SSPECFNPSQ STQLFQLLSL VLDSIGLFSL EGALLENLTL 660
  661 YIDKQVEIAE RNTELWNLID TKGFQHGFAS STFDNGTSQK RALPTYTMEY LDI

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) BMS1 DIM1 DIP2 ECM16 EMG1 ENP1 IMP3 KRE33 MPP10 NAN1 NOC4 NOP1 NOP14 NOP56 PNO1 POL5 PWP2 RRP12 RRP9 SOF1 UTP10 UTP13 UTP15 UTP20 UTP21 UTP22 UTP30 UTP4 UTP5 UTP6 UTP7 UTP8 UTP9
    View Details (MIPS) Mewes HW, et al. (2004) DRS1 GAR1 IFH1 NOP1 NPL3 NSR1 POP1 POP2 RAT1 RNT1 RRP3 SBP1 SNM1 SRD1 UTP10 UTP11 UTP13 UTP4 UTP5 UTP6 UTP7 UTP8 UTP9 YME2
    View Details Krogan NJ, et al. (2006) GFD2 NAN1 POL5 UTP10 UTP15 UTP4 UTP5 UTP8 UTP9
    View Details Gavin AC, et al. (2006) CMS1 DIP2 MRD1 NAN1 NOP14 NOP58 PNO1 PWP2 ROK1 RRP9 UTP10 UTP13 UTP15 UTP18 UTP21 UTP22 UTP4 UTP6 UTP7 UTP8 UTP9
    View Details Gavin AC, et al. (2002) ADE4 ASC1 BFR2 BMS1 BRX1 BUD21 CBF5 CFT2 CKA1 CKA2 CKB1 CKB2 CMS1 DBP8 DIA4 DIM1 DIP2 DIS3 ECM16 ECM29 EMG1 ENP1 ENP2 ERO1 ESF1 ESF2 FAP7 FIP1 GCN1 GLC7 HAS1 HCA4 HHF1, HHF2 HSL1 HTA2 IMP3 IMP4 KRE33 KRR1 LCP5 LTV1 MPP10 MRD1 MVD1 NAN1 NOB1 NOC2 NOC4 NOP1 NOP12 NOP14 NOP56 NOP58 NOP6 PAP1 PFS2 PNO1 PRE6 PRE9 PRP43 PTA1 PTI1 PWP2 RCL1 REF2 RML2 RNA14 ROK1 RPP2B RRP12 RRP7 RRP9 RTG2 SAM1 SCL1 SEC21 SLX9 SOF1 SRO9 TIF1, TIF2 TSR1 UTP10 UTP11 UTP13 UTP15 UTP18 UTP20 UTP21 UTP22 UTP30 UTP4 UTP6 UTP7 UTP8 UTP9 YOR059C YSH1
    View Details Qiu et al. (2008) BFR2 BUD21 DBP3 DBP7 DBP8 DHR2 DIP2 DRS1 ERB1 ESF1 FPR4 GAR1 HAS1 HCA4 IMP4 JIP5 KRR1 MAK5 NAN1 NOP1 NOP15 NOP4 NSA1 NSR1 NUG1 PWP2 PXR1 RCL1 RNT1 RRP1 RRP5 RRP9 SGD1 SOF1 SPB4 URB2 UTP10 UTP11 UTP13 UTP14 UTP15 UTP18 UTP20 UTP22 UTP4 UTP5 UTP6 UTP7 UTP8 UTP9

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run CEP3 sample cbf3 from feb 2005 Sandall S, et all (2006)
    View Run ZDS1 Sample 3 - cpn + atp, from june 2005 McCusker D, et al (2007)
    View Run MLP2 #32 Asynchronous Prep-No Phosphopeptide enrichment Keck JM, et al. (2011)
    View Run MLP2 #13 Mitotic Prep2-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)
    View Run MLP2 #10 Mitotic Prep1-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data UTP8 and SPC42 Unpublished Data
    View Data UTP8 and SPC42 Unpublished Data
    View Data UTP8 Huh WK, et al. (2003)
    View Data UTP8 and NOP56 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..713] deduced N/A No confident structure predictions are available.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.49

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle