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Protein Overview: SGD1

General Information:
Name(s) found: SGD1 / YLR336C [SGD]
Description(s) found:
Found 23 descriptions.
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  • Essential nuclear protein, required for biogenesis of the small ribosomal subunit; has a possible role in the osmoregulatory glycerol response; putative homolog of human NOM1 which is implicated in acute myeloid leukemia [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 899 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDALink to PubMed article][ISSLink to PubMed article]
    nucleolus [IDALink to PubMed article]
    Biological Process: RNA metabolic process [IEA]
    ribosomal small subunit biogenesis [IMP]
    hyperosmotic response [IGI]
    Molecular Function: molecular_function [ND]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MQKTDGIRIP GVILDELKTL DYSQDERFSI SEGKKRRRGN GKHLSRKEKR KMERADKKRK  60
   61 IISTREINSS RLKSAPTSEK RSANAGVKNV GKQANGKNPI SSDESESNEN WDSDEVLTDE 120
  121 VAEESGEQAM SAEETMKKLE SLKRKAKGIQ GAENSGEIKG NSYEKKHIRN RDTNENFVSY 180
  181 PLAPSDRSAF ERDEMDMQYY AKKLGLKGER KAIHAKDEFD AIGGLLEGLE YFENYGKSDE 240
  241 EYGDFATETN SMRKDDEASE KAFSSDDDLS ASDFEDSDGL SESDNDSVAD SDDNYRREKE 300
  301 NPYVAPTQSV ESYVPPSLRK KLDDSENNST LSEISKKVNS SLNKLSDSNI TIIITDLNRL 360
  361 YDSLPRQYVT ESLTKGILNI ISQNQKLLDG FIMNYAALAY TLSKLRGIEV GAFFIQKTVE 420
  421 AFLHHYEEEM ENILKDQQSK ISSKICINIA TLLSYCYNFG FVSCRLIYDI IRIFVADPNE 480
  481 FTTELLLRII SISGQLIRGD DPSALRDIRS ELLKNAKNLK EQSPRLRFLM DTMSDLKNNR 540
  541 LKPSILATDH HPLKKNLQSI LNSSSSWEPL QVSLEDIKNI DSKGKWWLVG ASWRGNMENA 600
  601 FEVSINNEND ASKSKKSKIS IEDDLLDDIP DWNIIARQQR MNTDIRRAIF ISIMSAQDYL 660
  661 DAFSKLEKLS LKNKQVLEIP RIVLHCLLAD SGSNGYNHYY ALVANKICER YSHLSKSFQF 720
  721 LFWDVIKKFE DKEFDSESDT DEEDDLDDKE KLLRISNQGR FFGSLLANDI LKLDVFKHVP 780
  781 FMGGLNTEGM LFMEILLFQL FLTVAKKSEK KLKMDESGNK RIIYSDDYLR DVLTKNVKSE 840
  841 NMLFILKGLK WFINKKFRYH NFLAGKKGDK AFDRDERRLA WASKAAKSII DKELENIDS

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Krogan NJ, et al. (2006) HFM1 LYS4 NEW1 RBG1 SGD1 SOK1 SSZ1 TCB1 TGL5 TMA46 YEF3 YLR072W ZUO1
    View Details Ho Y, et al. (2002) ACC1 CPR6 FAA4 LIA1 OLA1 RNR2 RPT4 SEC53 SGD1 UTP5 YER138C
    View Details Qiu et al. (2008) DBP7 DRS1 SGD1 UTP4 UTP6 UTP8 UTP9

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run CEP3 sample cbf3 from feb 2005 Sandall S, et all (2006)
    View Run BOI1 Sample boi1 with gst from october 2005 McCusker D, et al (2007)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data SGD1 and NOP56 Huh WK, et al. (2003)
    View Data SGD1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..309] MSA 38.272997 View MSA. No confident structure predictions are available.
    2 View Details [310..442] PSI-BLAST 43.0 Eukaryotic initiation factor eIF4G
    3 View Details [443..595] PSI-BLAST 43.0 Eukaryotic initiation factor eIF4G
    4 View Details [596..837] MSA 1.021948 View MSA. No confident structure predictions are available.
    5 View Details [838..899] deduced N/A No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • binding
    		•  2.51289989021257 bayes_pls_golite062009
  • protein binding
    		•  1.48452343997858 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.394131489393838 bayes_pls_golite062009
    3 No functions predicted.
    4
    Term Confidence Notes
  • binding
    		•  2.40695139302924 bayes_pls_golite062009
  • protein binding
    		•  1.35895139229414 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.342838152542467 bayes_pls_golite062009
    5 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.87

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle