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Protein Overview: LIA1

General Information:
Name(s) found: LIA1 / YJR070C [SGD]
Description(s) found:
Found 35 descriptions.
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  • Deoxyhypusine hydroxylase, a HEAT-repeat containing metalloenzyme that catalyzes hypusine formation; binds to and is required for the modification of Hyp2p (eIF5A); complements S. pombe mmd1 mutants defective in mitochondrial positioning [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 325 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDALink to PubMed article]
    cytoplasm [IDALink to PubMed article]
    Biological Process: ribosome biogenesis [RCALink to PubMed article]
    microtubule cytoskeleton organization [IGILink to PubMed article][IMPLink to PubMed article]
    Molecular Function: protein binding [IPILink to PubMed article]
    deoxyhypusine monooxygenase activity [IDALink to PubMed article][IMPLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSTNFEKHFQ ENVDECTLEQ LRDILVNKSG KTVLANRFRA LFNLKTVAEE FATKPEEAKK  60
   61 AIEYIAESFV NDKSELLKHE VAYVLGQTKN LDAAPTLRHV MLDQNQEPMV RHEAAEALGA 120
  121 LGDKDSLDDL NKAAKEDPHV AVRETCELAI NRINWTHGGA KDKENLQQSL YSSIDPAPPL 180
  181 PLEKDATIPE LQALLNDPKQ PLFQRYRAMF RLRDIGTDEA ILALATGFSA ESSLFKHEIA 240
  241 YVFGQIGSPA AVPSLIEVLG RKEEAPMVRH EAAEALGAIA SPEVVDVLKS YLNDEVDVVR 300
  301 ESCIVALDMY DYENSNELEY APTAN

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Ho Y, et al. (2002) ACC1 ARC35 ARG4 ARP2 AYR1 BGL2 CCT2 COR1 CPR6 ERG27 FAA4 GPT2 KGD2 LIA1 MAE1 OLA1 OM45 PCT1 PDA1 PET10 PET9 PIL1 PRE10 PRO3 RET2 RNR2 RPT4 RTN2 RVB2 RVS161 SEC18 SEC21 SEC26 SEC27 SEC28 SEC53 SEN2 SGD1 SHS1 TIF34 TIF35 TPA1 UTP5 YER138C YHR033W YNL181W

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run DAD1 Dam1-765 complex purified from yeast with Dad1-TAP Shimogawa MM, et al. (2006)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen PRP16 LIA1 2 Unpublished Fields Lab Data

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data LIA1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..142] PSI-BLAST 40.69897 Constant regulatory domain of protein phosphatase 2a, pr65alpha
    2 View Details [143..325] PSI-BLAST 40.69897 Constant regulatory domain of protein phosphatase 2a, pr65alpha


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.95

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle