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Protein Overview: ARP2

General Information:
Name(s) found: ARP2 / YDL029W [SGD]
Description(s) found:
Found 35 descriptions.
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  • Essential component of the Arp2/3 complex, which is a highly conserved actin nucleation center required for the motility and integrity of actin patches; involved in endocytosis and membrane growth and polarity [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 391 amino acids

    Gene Ontology:
    Cellular Component: mitochondrion [TASLink to PubMed article]
    Arp2/3 protein complex [IDALink to PubMed article]
    Biological Process: mitochondrion inheritance [IMPLink to PubMed article][IPILink to PubMed article]
    actin filament organization [IMPLink to PubMed article]
    Molecular Function: ATP binding [IDALink to PubMed article][IMPLink to PubMed article]
    actin binding [TASLink to PubMed article]
    structural constituent of cytoskeleton [TASLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDPHNPIVLD QGTGFVKIGR AGENFPDYTF PSIVGRPILR AEERASVATP LKDIMIGDEA  60
   61 SEVRSYLQIS YPMENGIIKN WTDMELLWDY AFFEQMKLPS TSNGKILLTE PPMNPLKNRE 120
  121 KMCEVMFEKY DFGGVYVAIQ AVLALYAQGL SSGVVVDSGD GVTHIVPVYE SVVLSHLTRR 180
  181 LDVAGRDVTR HLIDLLSRRG YAFNRTADFE TVRQIKEKLC YVSYDLDLDT KLARETTALV 240
  241 ESYELPDGRT IKVGQERFEA PECLFQPGLV DVEQPGVGEL LFNTVQSADV DIRSSLYKAI 300
  301 VLSGGSSMYP GLPSRLEKEL KQLWFSRVLH NDPSRLDKFK VRIEDPPRRK HMVFIGGAVL 360
  361 ASIMADKDHM WLSKQEWQES GPSAMTKFGP R

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) ARC15 ARC18 ARC19 ARC35 ARC40 ARP2 ARP3 CRN1 TWF1
    View Details (MIPS) Mewes HW, et al. (2004) ABP1 AIP1 ARC15 ARC18 ARC19 ARC35 ARC40 ARP2 ARP3 BEM1 BUD6 CAP1 CAP2 COF1 CRN1 DLD2 GLK1 LAS17 OYE2 PAN1 PFY1 RVS167 SAC6 SLA1 SLA2 SRV2 TPM1 TPM2 TWF1 VRP1
    View Details Krogan NJ, et al. (2006) ARC18 ARC19 ARC35 ARC40 ARP2 ARP3 PAC1 TAP42
    View Details Gavin AC, et al. (2006) ARC15 ARC18 ARC19 ARC35 ARC40 ARP2 ARP3
    View Details Gavin AC, et al. (2002) ARC15 ARC18 ARC19 ARC35 ARC40 ARP2 ARP3 CCT5 CCT8 NOG2 PFK1 PRT1
    View Details Ho Y, et al. (2002) AAC1 AAC3 ACC1 ADE5,7 ADR1 AHA1 ARC1 ARC15 ARC18 ARC19 ARC35 ARC40 ARO1 ARP2 ARP3 ATG11 ATG12 ATG17 ATP3 BCK1 BGL2 BNI1 BUL1 CAR2 CBK1 CCT2 CCT3 CCT5 CCT6 CLU1 CPA1 CPA2 CPR6 CYS4 DUR1,2 EGD2 FAA1 FAA4 FET3 FET4 FOL2 GAL7 GCD11 GFA1 GLT1 GND1 GPA1 GSF2 GUS1 HTB1 ICP55 IDH1 IDH2 ILV5 IMH1 IPP1 KAP122 KGD2 KIC1 KIN2 LHS1 LIA1 LYS12 MAE1 MCM4 MCM7 MDN1 MET18 MKK2 MKT1 MOB2 NAS6 NDE1 NIP1 NMD5 NOP4 NPA3 NTG1 OYE2 PDC6 PET10 PHO84 PIL1 PMA1 POB3 PPH21 PPH22 PPX1 PRB1 PRP28 PRP4 PST2 PTC7 PUF3 QCR2 RCN2 REP1 REX2 RFA1 RFC2 RGD1 RMT2 RNQ1 RNR1 RNR2 RNR3 RPA135 RPC40 RPN1 RPN10 RPN11 RPN12 RPN14 RPN3 RPN5 RPN6 RPN7 RPN8 RPN9 RPT1 RPT2 RPT3 RPT4 RPT5 RVB1 RVB2 SAN1 SAP155 SAP185 SAP190 SDH2 SEC18 SEC28 SHS1 SIS1 SIT4 SKG3 SLT2 SMK1 SPS1 SRP1 SSZ1 STE4 STI1 SWM1 TAO3 TAP42 TCB1 TCB3 TCP1 TIF1, TIF2 TIF34 TRP3 TYR1 UBC12 UBI4 URA7 VMA6 VMA8 VPS74 YHR020W YHR033W YJR029W YLR241W YMR196W YNL040W YNL134C YNL208W YPL113C
    View Details Qiu et al. (2008) ABP1 ABP140 ACT1 AIP1 ARC15 ARC18 ARC19 ARC35 ARC40 ARP2 ARP3 BBC1 BNI1 BUD6 CAP1 CAP2 COF1 CRN1 EDE1 ENT1 GLK1 IQG1 JNM1 LAS17 PAN1 PFY1 RVS167 SAC6 SCP1 SLA1 SLA2 SRV2 TPM1 TPM2 TWF1 VRP1

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run MLP2 #25 Asynchronous Prep3-TiO2 Flowthrough Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data ARP2 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..140]
    [353..391]    		 PSI-BLAST 2020.0 Actin
    2 View Details [141..352] PSI-BLAST 2020.0 Actin


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.87

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle