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Protein Overview: SIT4

General Information:
Name(s) found: SIT4 / YDL047W [SGD]
Description(s) found:
Found 31 descriptions.
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  • Type 2A-related serine-threonine phosphatase that functions in the G1/S transition of the mitotic cycle; cytoplasmic and nuclear protein that modulates functions mediated by Pkc1p including cell wall and actin cytoskeleton organization [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 311 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDALink to PubMed article]
    cytoplasm [IDALink to PubMed article]
    Biological Process: DNA repair [IMPLink to PubMed article]
    G1/S transition of mitotic cell cycle [IGILink to PubMed article]
    cellular cell wall organization [IMPLink to PubMed article]
    telomere maintenance [IMPLink to PubMed article]
    intracellular protein kinase cascade [IMPLink to PubMed article]
    protein amino acid phosphorylation [TASLink to PubMed article]
    replicative cell aging [IMPLink to PubMed article]
    actin cytoskeleton organization [IMPLink to PubMed article]
    Molecular Function: protein serine/threonine phosphatase activity [TASLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MVSRGPDEWL ETIKKCQALT ENEMKQLCEM VKELLMEESN IQPVQTPVTV CGDIHGQFHD  60
   61 LLELFRTAGG FPDDINYIFL GDYVDRGYYS LETFTLLMCL KVKYPAKITL VRGNHESRQI 120
  121 TQVYGFYEEC LNKYGSTTVW KYCCQVFDFL TLAAIIDGKI LCVHGGLSPE IRMLDQIRVL 180
  181 SRAQEVPHEG GFSDLLWSDP DNVEAWQVSP RGAGWLFGSK VAREFNHVNG LNLIARAHQL 240
  241 VMEGFKYHFP EKDVVTVWSA PNYCYRCGNV ASVMKVDEDL EPTFKIFSAV PDDYIRESTA 300
  301 NHNNQRAGYF L

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) SAP155 SAP185 SAP190 SIT4
    View Details Krogan NJ, et al. (2006) HRT3 PPZ2 SAP155 SDS24 SIT4
    View Details Gavin AC, et al. (2006) CDC25 HRK1 MDS3 SAP185 SIT4
    View Details Gavin AC, et al. (2002) ACC1 AVT4 BEM2 CCT2 CCT5 CDC25 DTD1 FAB1 HRK1 MDS3 MIA40 MRPL3 RAI1 RAT1 SAP155 SAP185 SAP190 SIT4 SWT21 VAC14
    View Details Ho Y, et al. (2002) ABP1 ACC1 ACO1 ADO1 AIM41 ARP2 ARP4 ATE1 ATG18 ATG20 ATP3 ATP4 BGL2 BUD14 CAR2 CCT6 CDC25 CDC33 CDC37 CKA2 COR1 CRZ1 CTK1 CYS4 DCP1 DCP2 DNM1 DOG1 DUR1,2 EAF1 EDC3 EDE1 EGD2 ENP1 EPL1 ESA1 FAA1 FAA4 FET4 FPR3 GAS1 GBP2 GCN3 GLC7 GLT1 GPH1 GSF2 HAS1 HHF1, HHF2 HRB1 HRR25 HSP104 HXT5 HXT7 HYP2 IPP1 KRE33 LOC1 LSP1 LTV1 MAE1 MAM33 MDH1 MDS3 MGE1 NDE1 NPA3 NPL3 NSA1 NUG1 OYE2 PEX19 PFK2 PIL1 PIM1 PIN4 POR1 PRP8 PTC4 PUF3 QCR2 RIO2 RMT2 RNR2 RPC19 RPM2 RPT4 SAP155 SAP185 SAP190 SAS10 SEC2 SEC23 SES1 SFB3 SFP1 SGM1 SIT4 SNP1 SRP1 TAF14 TAF4 TAP42 TGL1 THI21 TIP41 TMA19 TRA1 TSR1 TUF1 UTP13 VAC14 VMA4 YBR225W YER138C YMR196W YMR209C YRA1

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run RPA135 his-HA tag on RPA135 Schneider, DA, et al. (2006)
    View Run CEP3 sample cbf3 from feb 2005 Sandall S, et all (2006)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data SIT4 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..311] PSI-BLAST 847.218487 Protein phosphatase-1 (PP-1)


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle