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Protein Overview: KRE33

General Information:
Name(s) found: KRE33 / YNL132W [SGD]
Description(s) found:
Found 25 descriptions.
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  • Essential protein, required for biogenesis of the small ribosomal subunit; heterozygous mutant shows haploinsufficiency in K1 killer toxin resistance [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 1056 amino acids

    Gene Ontology:
    Cellular Component: nucleolus [IDALink to PubMed article]
    Biological Process: ribosome biogenesis [RCALink to PubMed article]
    Molecular Function: molecular_function [ND]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAKKAIDSRI PSLIRNGVQT KQRSIFVIVG DRARNQLPNL HYLMMSADLK MNKSVLWAYK  60
   61 KKLLGFTSHR KKRENKIKKE IKRGTREVNE MDPFESFISN QNIRYVYYKE SEKILGNTYG 120
  121 MCILQDFEAL TPNLLARTIE TVEGGGIVVI LLKSMSSLKQ LYTMTMDVHA RYRTEAHGDV 180
  181 VARFNERFIL SLGSNPNCLV VDDELNVLPL SGAKNVKPLP PKEDDELPPK QLELQELKES 240
  241 LEDVQPAGSL VSLSKTVNQA HAILSFIDAI SEKTLNFTVA LTAGRGRGKS AALGISIAAA 300
  301 VSHGYSNIFV TSPSPENLKT LFEFIFKGFD ALGYQEHIDY DIIQSTNPDF NKAIVRVDIK 360
  361 RDHRQTIQYI VPQDHQVLGQ AELVVIDEAA AIPLPIVKNL LGPYLVFMAS TINGYEGTGR 420
  421 SLSLKLIQQL RNQNNTSGRE STQTAVVSRD NKEKDSHLHS QSRQLREISL DEPIRYAPGD 480
  481 PIEKWLNKLL CLDVTLIKNP RFATRGTPHP SQCNLFVVNR DTLFSYHPVS ENFLEKMMAL 540
  541 YVSSHYKNSP NDLQLMSDAP AHKLFVLLPP IDPKDGGRIP DPLCVIQIAL EGEISKESVR 600
  601 NSLSRGQRAG GDLIPWLISQ QFQDEEFASL SGARIVRIAT NPEYASMGYG SRAIELLRDY 660
  661 FEGKFTDMSE DVRPKDYSIK RVSDKELAKT NLLKDDVKLR DAKTLPPLLL KLSEQPPHYL 720
  721 HYLGVSYGLT QSLHKFWKNN SFVPVYLRQT ANDLTGEHTC VMLNVLEGRE SNWLVEFAKD 780
  781 FRKRFLSLLS YDFHKFTAVQ ALSVIESSKK AQDLSDDEKH DNKELTRTHL DDIFSPFDLK 840
  841 RLDSYSNNLL DYHVIGDMIP MLALLYFGDK MGDSVKLSSV QSAILLAIGL QRKNIDTIAK 900
  901 ELNLPSNQTI AMFAKIMRKM SQYFRQLLSQ SIEETLPNIK DDAIAEMDGE EIKNYNAAEA 960
  961 LDQMEEDLEE AGSEAVQAMR EKQKELINSL NLDKYAINDN SEEWAESQKS LEIAAKAKGV1020
 1021 VSLKTGKKRT TEKAEDIYRQ EMKAMKKPRK SKKAAN

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) BFR2 BMS1 CBF5 DIP2 ECM16 EMG1 ENP1 ENP2 ERB1 FUN12 HCA4 IMD1 IMD3 IMD4 IMP3 KRE33 KRI1 KRR1 LCP5 MPP10 NAN1 NOC4 NOP1 NOP12 NOP14 NOP56 NOP58 PRP43 PUF6 PWP1 PWP2 RBG1 ROK1 RPF2 RPL10 RPL15A RPL20B RPL2A, RPL2B RPP0 RPS11A, RPS11B RPS13 RPS1A RPS1B RPS24A, RPS24B RPS3 RPS4B, RPS4A RPS6A, RPS6B RPS7A RPS8B, RPS8A RRP12 RRP9 SOF1 STM1 TSR1 UTP10 UTP13 UTP15 UTP20 UTP21 UTP22 UTP30 UTP4 UTP6 UTP7 UTP8
    View Details Krogan NJ, et al. (2006) BFR2 FUN14 HCA4 KRE33 LCP5
    View Details Gavin AC, et al. (2006) DIP2 EMG1 ENP1 ENP2 KRE33 KRR1 NOC4 NOP14 ROK1 UTP22 UTP6 UTP7
    View Details Gavin AC, et al. (2002) AAR2 ADE4 ADH1 ARX1 ASC1 BDF2 BEM2 BFR2 BMS1 BRX1 BUD20 BUD21 CBF5 CDC55 CFT2 CIC1 CKA1 CKA2 CKB1 CKB2 CLU1 CMS1 CYR1 CYS4 DBP10 DBP8 DBP9 DCP2 DIA4 DIM1 DIP2 DIS3 DRS1 DYN1 EBP2 ECM16 ECM29 ECM5 EMG1 ENP1 ENP2 ERB1 ERO1 ESF1 ESF2 FAP7 FIP1 FPR4 FUN12 GAR1 GCN1 GLC7 GLY1 HAS1 HAT1 HAT2 HCA4 HDA1 HER1 HHF1, HHF2 HIF1 HIS3 HRR25 HSL1 HSM3 HTA2 ICL1 IML1 IMP3 IMP4 INP2 IPI1 IPI3 KAP123 KRE33 KRR1 LCP5 LHP1 LIP2 LOC1 LSG1 LTV1 MAC1 MAK21 MAK5 MDN1 MIS1 MPP10 MRD1 MRP7 MRT4 MSB1 MVD1 NAN1 NAP1 NHP2 NIP1 NIP7 NMD3 NMD5 NOB1 NOC2 NOC3 NOC4 NOG1 NOG2 NOP1 NOP12 NOP14 NOP15 NOP16 NOP2 NOP4 NOP56 NOP58 NOP6 NOP7 NSA1 NSA2 NUG1 PAP1 PFK1 PFS2 PNO1 POL2 PRE6 PRE9 PRO1 PRP4 PRP43 PRT1 PSD2 PSE1 PSH1 PTA1 PTI1 PUF6 PWP2 RCL1 REF2 REI1 RIO2 RIX1 RIX7 RLP24 RLP7 RML2 RNA14 ROK1 RPA135 RPA190 RPC40 RPF1 RPF2 RPG1 RPN12 RPN3 RPN6 RPN8 RPN9 RPP2B RPT2 RPT3 RPT5 RPT6 RRP1 RRP12 RRP7 RRP9 RSA3 RSA4 RSC3 RTG2 RTR1 SAM1 SCL1 SDA1 SEC21 SEC7 SKI2 SLX9 SMB1 SNF2 SNF5 SNU114 SNU13 SNU66 SOF1 SPB1 SPB4 SRO9 SSF1 SWI3 TEL1 TIF1, TIF2 TIF4631 TIF4632 TIF6 TSC11 TSR1 TUB3 URB1 USO1 UTP10 UTP11 UTP13 UTP15 UTP18 UTP20 UTP21 UTP22 UTP30 UTP4 UTP6 UTP7 UTP8 UTP9 VTH2 YFR006W YGL036W YGR054W YMR310C YOR059C YPR077C YSH1 YTM1
    View Details Ho Y, et al. (2002) ADH2 AIM46 APM1 ARE1 BMS1 BRX1 BUD3 CBF5 CBP2 CCM1 CCT2 CCT3 CCT6 CDC16 CDC33 CDC37 CDC53 CIC1 CIN8 CKA1 CKA2 CKB1 CKB2 CLU1 COF1 CTF4 CTK1 DBP10 DBP2 DBP7 DED81 DIA2 DIP2 DRS1 EGD1 ELA1 ENP1 ENP2 ERB1 ESL2 EST1 FET4 FPR3 FUN12 GBP2 GRS1 HAS1 HHF1, HHF2 HHT1, HHT2 HIR1 HMO1 HOT1 HRB1 HSH49 HTA1 HTB1 HTB2 ILS1 IMD1 IMD2 IMD3 IMD4 ISA1 KAP95 KRE33 KRE6 KRI1 KRR1 LCP5 LOC1 LST4 MAG2 MCM2 MCM3 MCM5 MES1 MGM101 MKT1 MMS4 MNP1 MRM1 MSC3 MSS116 MUS81 NAN1 NHP2 NIP7 NMD3 NOC2 NOG1 NOP1 NOP12 NOP2 NOP4 NOP56 NOP58 NOP6 NOP7 NPL3 NUG1 OYE2 PDC6 PDI1 PET127 PNO1 POB3 POL5 PRP40 PRP43 PTC5 PUF6 PWP1 PWP2 RAD53 RLI1 RPC10 RPF2 RPN1 RRP1 RRP12 RRP5 RVB1 SEC23 SEH1 SFP1 SIT4 SKP1 SLT2 SOF1 SPB1 SPT16 SSD1 SSF1 SSF2 SSZ1 TAF14 TFP1 TIF1, TIF2 TIF4631 TIF4632 TIF6 TMA19 TPT1 TRA1 TSR1 UBI4 UFD4 URB1 URB2 UTP10 UTP11 UTP13 UTP14 UTP18 UTP20 UTP21 UTP22 UTP30 UTP6 UTP7 YAK1 YBL104C YER077C YER084W YGR054W YHB1 YPP1 YRA1 YTM1
    View Details Qiu et al. (2008) BRX1 DBP6 ENP1 GAR1 KRE33 KRI1 KRR1 NOP15 NUG1 PWP2 PXR1 RPF2 RRP1 RRP9 TIF6 UTP15 UTP5

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run VAM3 Sample: HX12 - trans-SNARE complex formation and fusion are inhibited (control). Hao Xu, et al. (2010)
    View Run MLP2 #29 Asynchronous Prep5-TiO2 Flowthrough Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data KRE33 Huh WK, et al. (2003)
    View Data KRE33 and NOP56 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..101] deduced N/A No confident structure predictions are available.
    2 View Details [102..720] MSA 4.027892 View MSA. No confident structure predictions are available.
    3 View Details [721..814] MSA 1.020986 View MSA. No confident structure predictions are available.
    4 View Details [815..1056] deduced N/A No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3
    Term Confidence Notes
  • structural constituent of ribosome
    		•  2.58352785213483 bayes_pls_golite062009
  • binding
    		•  2.3830857772509 bayes_pls_golite062009
  • structural molecule activity
    		•  1.70306030734033 bayes_pls_golite062009
  • RNA helicase activity
    		•  1.40594009629203 bayes_pls_golite062009
  • ATP-dependent RNA helicase activity
    		•  1.38650114394757 bayes_pls_golite062009
  • RNA-dependent ATPase activity
    		•  1.372924601535 bayes_pls_golite062009
  • helicase activity
    		•  1.17712281740941 bayes_pls_golite062009
  • ATP-dependent helicase activity
    		•  1.12969667337016 bayes_pls_golite062009
  • purine NTP-dependent helicase activity
    		•  1.12969667337016 bayes_pls_golite062009
  • RNA binding
    		•  0.90930722867621 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.61841039337932 bayes_pls_golite062009
    		• 0.506052368661833 bayes_pls_golite062009
  • DNA binding
    		•  0.327221599656875 bayes_pls_golite062009
  • transcription regulator activity
    		•  0.179080000736404 bayes_pls_golite062009
  • protein binding
    		•  0.102043618157662 bayes_pls_golite062009
  • nucleoside-triphosphatase activity
    		•  0.0283323446458181 bayes_pls_golite062009
    4 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.89

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle