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Protein Overview: TEL1

General Information:
Name(s) found: TEL1 / YBL088C [SGD]
Description(s) found:
Found 18 descriptions.
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  • Protein kinase primarily involved in telomere length regulation; contributes to cell cycle checkpoint control in response to DNA damage; functionally redundant with Mec1p; homolog of human ataxia telangiectasia (ATM) gene [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 2787 amino acids

    Gene Ontology:
    Cellular Component: nucleus [ICLink to PubMed articleLink to PubMed article][TASLink to PubMed article]
    mitochondrion [IDALink to PubMed articleLink to PubMed article]
    Biological Process: DNA double-strand break processing [IGILink to PubMed article][IMPLink to PubMed article]
    telomere maintenance [IMPLink to PubMed article]
    telomere maintenance via telomerase [IMPLink to PubMed article]
    phosphorylation [IMPLink to PubMed article]
    response to DNA damage stimulus [IMPLink to PubMed article]
    Molecular Function: protein kinase activity [IDALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MEDHGIVETL NFLSSTKIKE RNNALDELTT ILKEDPERIP TKALSTTAEA LVELLASEHT  60
   61 KYCDLLRNLT VSTTNKLSLS ENRLSTISYV LRLFVEKSCE RFKVKTLKLL LAVVPELMVK 120
  121 DGSKSLLDAV SVHLSFALDA LIKSDPFKLK FMIHQWISLV DKICEYFQSQ MKLSMVDKTL 180
  181 TNFISILLNL LALDTVGIFQ VTRTITWTVI DFLRLSKKEN GNTRLIMSLI NQLILKCHCF 240
  241 SVIDTLMLIK EAWSYNLTIG CTSNELVQDQ LSLFDVMSSE LMNHKLPYMI GQENYVEELR 300
  301 SESLVSLYRE YILLRLSNYK PQLFTVNHVE FSYIRGSRDK NSWFALPDFR LRDRGGRSVW 360
  361 LKILGITKSL LTYFALNRKN ENYSLLFKRR KCDSDIPSIL RISDDMDTFL IHLLEENSSH 420
  421 EFEVLGLQLC SFYGTLQDFT KSFAEQLKEL LFSKFEKIQC FNWVCFSFIP LLSQKECELS 480
  481 NGDMARLFKV CLPLVKSNES CQLSCLLLAN SIKFSKQLLS DEKTINQIYD LYELSDILGP 540
  541 ILVTNESFML WGYLQYVGKD FQSMNGISSA DRIFEWLKSK WNQLRGTDAK QDQFCNFISW 600
  601 LGNKYDPENP FNDKKGEGAN PVSLCWDESH KIWQHFQEQR EFLLGVKPEE KSECFNTPFF 660
  661 NLPKVSLDLT RYNEILYRLL ENIESDAFSS PLQKFTWVAK LIQIVDNLCG DSTFSEFIAA 720
  721 YKRTTLITIP QLSFDSQNSY QSFFEEVLSI RTINVDHLVL DKINMKEIVN DFIRMQKNKS 780
  781 QTGTSAINYF EASSEDTTQN NSPYTIGGRF QKPLHSTIDK AVRAYLWSSR NKSISERLVA 840
  841 ILEFSDCVST DVFISYLGTV CQWLKQAIGE KSSYNKILEE FTEVLGEKLL CNHYSSSNQA 900
  901 MLLLTSYIEA IRPQWLSYPE QPLNSDCNDI LDWIISRFED NSFTGVAPTV NLSMLLLSLL 960
  961 QNHDLSHGSI RGGKQRVFAT FIKCLQKLDS SNIINIMNSI SSYMAQVSYK NQSIIFYEIK1020
 1021 SLFGPPQQSI EKSAFYSLAM SMLSLVSYPS LVFSLEDMMT YSGFNHTRAF IQQALNKITV1080
 1081 AFRYQNLTEL FEYCKFDLIM YWFNRTKVPT SKLEKEWDIS LFGFADIHEF LGRYFVEISA1140
 1141 IYFSQGFNQK WILDMLHAIT GNGDAYLVDN SYYLCIPLAF ISGGVNELIF DILPQISGKT1200
 1201 TVKYHKKYRL LMLKWIIRFT DLGSLTELRS TVEKLFPTSY LSPYLFENSS VSMRYQYPLH1260
 1261 IPLALGATLV QTQFAHEKNN THEFKLLFLS VITDLEKTST YIGKLRCARE LKYLFVLYEN1320
 1321 VLVKSSTLNF IIIRLSKFLI DTQIHDEVIT IFSSLLNLAD KNTFEIEPSL PNLFCKIFIY1380
 1381 LRENKQLSPS FQQAIKLLEH RDLIKIKTWK YFLDAIFGNI VQDDIYENTE LLDASDCGVD1440
 1441 DVVLVSLLFS YARRPVASKI GCSLSKAAAI NILKHHVPKE YLSKNFKLWF AALSRRILQQ1500
 1501 EVQRERSTNF NNEVHLKNFE MVFRHPEQPH MIYQRISTFN KEAELYDSTE VFFISECILT1560
 1561 YLVGYSIGNS ESEFCFRDNI MNENKDKVAP LDKDVLNAIY PLANNFGMES FICDTYLSVN1620
 1621 EPYNCWLSKF ARSLIHQISF NIPPIVCLYP LCKGSTAFCE LVLTDLFFLS TTYDPKSCLN1680
 1681 WSNRIFTQIA MLLHVKDSEI KLKMLFNVIK MIRMGSRCKE RNCLRIYSSL DLQEICQISL1740
 1741 KIKEFKFGYL LFEEMNMPNI REMNINTLQK IYECINDGDF LAGLPVPHSI EGVLNSINRI1800
 1801 DSDTWKRFLF NNADFDANYT TSLEEEKESL IKATEDSGFY GLTSLLESRL SGSSDVYKWN1860
 1861 LELGDWKLLT PKVVDSKAKG LYYAIKNLPQ DVGFAEKSLE KSLLTIFDSR QHFISQTEWM1920
 1921 DTLNAIIEFI KIAAIPQDVT SFPQTLMSIM KADKERLNTI DFYDHKTTLK SRHTLMNVLS1980
 1981 RNSLDENVKC SKYLRLGSII QLANYVQLAI ANGAPQDALR NATLMSKTVK NIAKLYDDPS2040
 2041 VVSQIEKLAS FTSANALWES REYKAPVMIM RDLLAQNEKN ISESILYDDF KLLINVPMDQ2100
 2101 IKARLVKWSS ESRLEPAAAI YEKIIVNWDI NVEDHESCSD VFYTLGSFLD EQAQKLRSNG2160
 2161 EIEDREHRSY TGKSTLKALE LIYKNTKLPE NERKDAKRHY NRVLLQYNRD SEVLKALLLQ2220
 2221 KEKFLWHALH FYLNTLVFSN RYDNDIIDKF CGLWFENDDN SKINQLLYKE IGTIPSWKFL2280
 2281 PWVNQIASKI SMEENEFQKP LQLTMKRLLY KLPYDSLYSV MSILLYEKQS NKDTNISQKI2340
 2341 QAVKKILLEL QGYDRGAFAK KYLLPVQEFC EMSVELANLK FVQNTKTLRL ANLKIGQYWL2400
 2401 KQLNMEKLPL PTSNFTVKSS ADGRKARPYI VSVNETVGIT TTGLSLPKIV TFNISDGTTQ2460
 2461 KALMKGSNDD LRQDAIMEQV FQQVNKVLQN DKVLRNLDLG IRTYKVVPLG PKAGIIEFVA2520
 2521 NSTSLHQILS KLHTNDKITF DQARKGMKAV QTKSNEERLK AYLKITNEIK PQLRNFFFDS2580
 2581 FPDPLDWFEA KKTYTKGVAA SSIVGYILGL GDRHLNNILL DCSTGEPIHI DLGIAFDQGK2640
 2641 LLPIPELVPF RLTRDIVDGF GVTGVDGLFR RSCERVYAVL RKDYVKVMCV LNILKWDPLY2700
 2701 SWVMSPVKKY EHLFEEEHEI TNFDNVSKFI SNNDRNENQE SYRALKGVEE KLMGNGLSVE2760
 2761 SSVQDLIQQA TDPSNLSVIY MGWSPFY

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Gavin AC, et al. (2002) BDF2 CDC55 CKB1 DYN1 ECM5 FUN30 GLY1 HAT1 HAT2 HHF1, HHF2 HIF1 HSM3 ICL1 IML1 KAP123 KRE33 LIP2 MAC1 MDN1 MIS1 MSB1 NIP1 NMD5 PFK1 PRO1 PRT1 PSD2 PSE1 PSH1 RPA135 RPC40 RPG1 RPN12 RPN3 RPN6 RPN8 RPN9 RPT2 RPT3 RPT5 RPT6 RSC3 SAM1 TEL1 TSC11 USO1 UTP20 VTH2 YFR006W YPR077C
    View Details Ho Y, et al. (2002) GDE1 TEL1

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run KIP3 No Comments Cheeseman IM, et al. (2002)
    View Run RBA50 No Comments Hazbun TR, et al. (2003)
    View Run RPA135 No Comments Schneider, DA, et al. (2006)
    View Run MLP2 #19 Asynchronous Prep1-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)
    View Run MLP2 #03 Alpha Factor Prep1-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #29 Asynchronous Prep5-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #19b Asynchronous Prep1-new search criteria Keck JM, et al. (2011)
    View Run MLP2 #19a Asynchronous Prep1-new search criteria Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen TEL1 YJL114W 2 Unpublished Fields Lab Data
    View Screen TEL1 PET494 2 Unpublished Fields Lab Data
    View Screen TEL1 PET494 2 Unpublished Fields Lab Data
    View Screen TEL1 RUD3 2 Unpublished Fields Lab Data

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..1325] MSA 1.002001 View MSA. No confident structure predictions are available.
    2 View Details [1326..1719] deduced N/A No confident structure predictions are available.
    3 View Details [1720..2102] Pfam 12.537602 FAT domain No confident structure predictions are available.
    4 View Details [2103..2754] PSI-BLAST 167.980454 Phoshoinositide 3-kinase (PI3K) helical domain; Phoshoinositide 3-kinase (PI3K); Phoshoinositide 3-kinase (PI3K), catalytic domain
    5 View Details [2755..2787] Pfam 15.920819 FATC domain No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3 No functions predicted.
    4
    Term Confidence Notes
  • protein kinase activity
    		•  5.4586557943719 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  5.04467222534257 bayes_pls_golite062009
  • kinase activity
    		•  4.85903980916957 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  4.63692708178478 bayes_pls_golite062009
  • protein serine/threonine kinase activity
    		•  4.46381887831481 bayes_pls_golite062009
  • transferase activity
    		•  3.26787750561728 bayes_pls_golite062009
  • binding
    		•  2.74863538127007 bayes_pls_golite062009
  • protein binding
    		•  2.276111749106 bayes_pls_golite062009
  • ATP binding
    		•  1.97600611746091 bayes_pls_golite062009
  • adenyl ribonucleotide binding
    		•  1.93596671856664 bayes_pls_golite062009
  • adenyl nucleotide binding
    		•  1.90928021591891 bayes_pls_golite062009
  • purine ribonucleotide binding
    		•  1.65732943334212 bayes_pls_golite062009
  • ribonucleotide binding
    		•  1.65726906484847 bayes_pls_golite062009
  • purine nucleotide binding
    		•  1.63763394711025 bayes_pls_golite062009
  • nucleotide binding
    		•  1.63195828048121 bayes_pls_golite062009
  • protein tyrosine kinase activity
    		•  1.3898059094397 bayes_pls_golite062009
  • receptor signaling protein serine/threonine kinase activity
    		•  1.38496328649031 bayes_pls_golite062009
  • receptor signaling protein activity
    		•  1.27291233344322 bayes_pls_golite062009
  • catalytic activity
    		•  1.21655087018101 bayes_pls_golite062009
  • calcium-dependent phospholipid binding
    		•  1.06635493706319 bayes_pls_golite062009
  • transmembrane receptor protein kinase activity
    		•  0.684204466593894 bayes_pls_golite062009
  • cyclin-dependent protein kinase activity
    		•  0.499492353295369 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.444972929276369 bayes_pls_golite062009
  • magnesium ion binding
    		•  0.393328812780268 bayes_pls_golite062009
  • clathrin binding
    		•  0.35775052108553 bayes_pls_golite062009
  • neurexin binding
    		•  0.27749877320051 bayes_pls_golite062009
  • MAP kinase activity
    		•  0.26024936404169 bayes_pls_golite062009
  • transcription regulator activity
    		•  0.222474717779546 bayes_pls_golite062009
  • DNA binding
    		•  0.198054762876122 bayes_pls_golite062009
  • transmembrane receptor protein tyrosine kinase activity
    		•  0.196560862858137 bayes_pls_golite062009
  • SNARE binding
    		•  0.102282725391911 bayes_pls_golite062009
  • nuclear localization sequence binding
    		•  0.0935103343162811 bayes_pls_golite062009
  • transcription factor activity
    		•  0.026050048647416 bayes_pls_golite062009
    5 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.75

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle