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A cascade of processes induced by the detection of DNA damage within a cell. Any process that occur in response to the presence of critically short telomeres. A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. The series of events required to receive a stimulus indicating DNA damage has occurred and convert it to a molecular signal. A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation). The process by which a DNA replication fork that has stalled (due to DNA damage, DNA secondary structure, bound proteins, dNTP shortage, or other causes) is repaired and replication is restarted. A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation). A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism. The widespread phosphorylation of various molecules, triggering many downstream processes, that occurs in response to the detection of DNA damage.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: response to DNA damage stimulus
Acc: GO:0006974
Aspect: Biological Process
Desc: A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism.
Synonyms:
  • DNA damage response
  • cellular DNA damage response
  • GO:0034984
  • cellular response to DNA damage stimulus
  • response to genotoxic stress
Proteins in PDR annotated with:
   This term: 596 [Search]
   Term or descendants: 2430 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0006974 - response to DNA damage stimulus (interactive image map)
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