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Protein Overview: KIP3

General Information:
Name(s) found: KIP3 / YGL216W [SGD]
Description(s) found:
Found 23 descriptions.
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  • Kinesin-related motor protein involved in mitotic spindle positioning [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 805 amino acids

    Gene Ontology:
    Cellular Component: nuclear microtubule [IDALink to PubMed article]
    kinesin complex [TASLink to PubMed article]
    cytoplasmic microtubule [IDALink to PubMed article]
    Biological Process: establishment of mitotic spindle orientation [IGILink to PubMed article][IMPLink to PubMed article]
    nuclear migration along microtubule [IMPLink to PubMed article]
    mitotic spindle organization in nucleus [IGILink to PubMed article][IMPLink to PubMed article]
    mitotic spindle disassembly [IMPLink to PubMed article]
    microtubule depolymerization [IMPLink to PubMed article]
    Molecular Function: microtubule motor activity [TASLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNVPETRQSS IVVAIRVRPF TSMEKTRLVN EASGAEANFP GLGDSSLILP MSNNSDSDID  60
   61 IDAEEGSTRS KRNSLLRRKV IRPEGIRKIV DCVDDRMLIF DPADRNPLNK VSDQVLNSMR 120
  121 ARATKATASS INNSNATNKF SSQRRRHGGE IKFVFDKLFD ETSSQARVYK ETTSPLLDSV 180
  181 LDGFNSTVFA YGATGCGKTY TVSGTPSQPG IIFLAMEELF NKITDLKDEK DFEISLSYLE 240
  241 IYNERIRDLL KPETPSKRLV IREDTQNHIK VANLSYHHPN TVEDVMDLVV QGNINRTTSP 300
  301 TEANEVSSRS HAVLQIHIMQ TNKLVDLTSQ HTFATLSIID LAGSERAAAT RNRGIRLHEG 360
  361 ANINRSLLAL GNCINALCLN DGSRSCHIPY RDSKLTRLLK FSLGGNCKTV MIVCISPSSS 420
  421 HYDETLNTLK YANRAKEIKT KIIRNQQSLS RHVGSYLKMI TEQKRQIEEL REREEKMISL 480
  481 KLTKYKLNKE KIQLAINECV NRVQQTYAGV ETYQVAKTLK SLILCKRRFL QMVKLEVDNL 540
  541 ILLFEREEST AAEMQPVISN CRMISGQLYN KIHELEMKFD ETDTLSSVIH QVHSIDLNKL 600
  601 REMEDWDETY DLVYLESCLN QISELQRNEI LVNSSIMTEK LMSDPGLNSR FKFLSKWLMN 660
  661 RTPNIESIIQ DLVHIDEEFE SFARTFIANP DSNFTNTNIN IINTTAADLA VPAETLQRQN 720
  721 FSQKKVKWTS PDLSPSPMIE PQPELEPELH QDQDAIASEV DVSMQDTTFN EQGPSTPSAP 780
  781 TTAVPRRKMR SSLLTHQSLL ATARK

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details (MIPS) Mewes HW, et al. (2004) CIK1 CIN8 COG7 KAR3 KIP1 KIP2 KIP3 LIN1
    View Details Ho Y, et al. (2002) BUD13 CLU1 GND1 HEF3 KIP3 MDH1
    View Details Qiu et al. (2008) BIK1 BIM1 CIK1 CIN8 DYN1 DYN2 DYN3 HSK3 KAR3 KIP1 KIP2 KIP3 MHP1 MYO2 PAC11 TUB1

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run KIP3 No Comments Cheeseman IM, et al. (2002)
    View Run RPA135 No Comments Schneider, DA, et al. (2006)
    View Run MLP2 #14 Mitotic Prep2-TiO2 Flowthrough Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data KIP3 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..101] deduced N/A No confident structure predictions are available.
    2 View Details [102..466] PSI-BLAST 636.0103 Kinesin
    3 View Details [467..805] PSI-BLAST 12.39794 Heavy meromyosin subfragment

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • microtubule motor activity
    		•  7.68336791348661 bayes_pls_golite062009
  • plus-end-directed microtubule motor activity
    		•  4.97507344344589 bayes_pls_golite062009
  • tubulin-dependent ATPase activity
    		•  4.65311977287923 bayes_pls_golite062009
  • microfilament motor activity
    		•  4.176620576177 bayes_pls_golite062009
  • motor activity
    		•  4.04927796049806 bayes_pls_golite062009
  • nucleoside-triphosphatase activity
    		•  2.95079405147356 bayes_pls_golite062009
  • pyrophosphatase activity
    		•  2.87427509025394 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides
    		•  2.85499564954033 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
    		•  2.85178667290149 bayes_pls_golite062009
  • actin-dependent ATPase activity
    		•  2.77140616759165 bayes_pls_golite062009
  • microtubule plus-end binding
    		•  2.71138928021716 bayes_pls_golite062009
  • tubulin binding
    		•  2.67743463093593 bayes_pls_golite062009
  • binding
    		•  2.64537357529343 bayes_pls_golite062009
  • microtubule binding
    		•  2.59155206524122 bayes_pls_golite062009
  • transporter activity
    		•  2.58140740499725 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  2.4101693596493 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  2.39695871109024 bayes_pls_golite062009
  • ATPase activity
    		•  2.39535714892224 bayes_pls_golite062009
  • ATPase activity, coupled
    		•  2.18396165590908 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.84541587592638 bayes_pls_golite062009
  • actin binding
    		•  1.75397031486306 bayes_pls_golite062009
  • hydrolase activity
    		•  1.57549510726226 bayes_pls_golite062009
  • DNA binding
    		•  1.48341220422804 bayes_pls_golite062009
  • general RNA polymerase II transcription factor activity
    		•  1.40384549325664 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.30136714640988 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  1.29730375126024 bayes_pls_golite062009
  • protein binding
    		•  1.22129154759482 bayes_pls_golite062009
  • DNA-dependent ATPase activity
    		•  1.07479235523606 bayes_pls_golite062009
  • catalytic activity
    		•  1.00104173493322 bayes_pls_golite062009
  • purine nucleotide binding
    		•  0.929901285538132 bayes_pls_golite062009
  • nucleotide binding
    		•  0.922442819194247 bayes_pls_golite062009
  • purine ribonucleotide binding
    		•  0.920987930180051 bayes_pls_golite062009
  • ribonucleotide binding
    		•  0.920926158369519 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  0.906554174337376 bayes_pls_golite062009
  • actin filament binding
    		•  0.728264616959762 bayes_pls_golite062009
  • ATP-dependent DNA helicase activity
    		•  0.58184133092316 bayes_pls_golite062009
  • kinetochore binding
    		•  0.505370954958131 bayes_pls_golite062009
  • GTPase activity
    		•  0.437665353870877 bayes_pls_golite062009
  • active transmembrane transporter activity
    		•  0.434775387083003 bayes_pls_golite062009
  • ATP binding
    		•  0.41092997612902 bayes_pls_golite062009
  • guanyl nucleotide binding
    		•  0.399434758448606 bayes_pls_golite062009
  • GTP binding
    		•  0.398333597279278 bayes_pls_golite062009
  • guanyl ribonucleotide binding
    		•  0.39332178627529 bayes_pls_golite062009
  • adenyl ribonucleotide binding
    		•  0.385813421701492 bayes_pls_golite062009
  • adenyl nucleotide binding
    		•  0.377870145186619 bayes_pls_golite062009
  • guanylate kinase activity
    		•  0.36604371735126 bayes_pls_golite062009
  • ion transmembrane transporter activity
    		•  0.355466224802969 bayes_pls_golite062009
  • RNA helicase activity
    		•  0.34746349346164 bayes_pls_golite062009
  • transcription factor activity
    		•  0.341088753451767 bayes_pls_golite062009
  • histone acetyltransferase activity
    		•  0.328186246219424 bayes_pls_golite062009
  • lysine N-acetyltransferase activity
    		•  0.328186246219424 bayes_pls_golite062009
  • ATP-dependent RNA helicase activity
    		•  0.30832907234141 bayes_pls_golite062009
  • RNA-dependent ATPase activity
    		•  0.29532978396745 bayes_pls_golite062009
  • primary active transmembrane transporter activity
    		•  0.294474570607914 bayes_pls_golite062009
  • P-P-bond-hydrolysis-driven transmembrane transporter activity
    		•  0.282352478532746 bayes_pls_golite062009
  • transcription repressor activity
    		•  0.244736544804496 bayes_pls_golite062009
  • helicase activity
    		•  0.243380876721902 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances
    		•  0.220608508617331 bayes_pls_golite062009
  • ATPase activity, coupled to transmembrane movement of substances
    		•  0.219533217661421 bayes_pls_golite062009
  • ATPase activity, coupled to movement of substances
    		•  0.219157471322311 bayes_pls_golite062009
  • protein transporter activity
    		•  0.178442534411253 bayes_pls_golite062009
  • mismatched DNA binding
    		•  0.13866566261611 bayes_pls_golite062009
  • minus-end-directed microtubule motor activity
    		•  0.068779631341469 bayes_pls_golite062009
  • cation transmembrane transporter activity
    		•  0.0254369227200564 bayes_pls_golite062009
  • structural constituent of cytoskeleton
    		•  0.0111338193708552 bayes_pls_golite062009
  • structural constituent of ribosome
    		•  0.0102645529518819 bayes_pls_golite062009
    3 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle