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Protein Overview: BIK1

General Information:
Name(s) found: BIK1 / YCL029C [SGD]
Description(s) found:
Found 25 descriptions.
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  • Microtubule-associated protein, component of the interface between microtubules and kinetochore, involved in sister chromatid separation; essential in polyploid cells but not in haploid or diploid cells; ortholog of mammalian CLIP-170 [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 440 amino acids

    Gene Ontology:
    Cellular Component: spindle microtubule [IDALink to PubMed article]
    cell cortex [IDALink to PubMed article]
    spindle pole body [IDALink to PubMed article]
    spindle [IDALink to PubMed article]
    condensed nuclear chromosome kinetochore [IDALink to PubMed article]
    kinetochore [IDALink to PubMed article]
    Biological Process: mitotic spindle elongation [IGILink to PubMed article]
    mitotic anaphase B [TASLink to PubMed article]
    mitotic spindle organization in nucleus [TASLink to PubMed article]
    karyogamy involved in conjugation with cellular fusion [IMPLink to PubMed article]
    Molecular Function: microtubule binding [IGILink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDRYQRKIGC FIQIPNLGRG QLKYVGPVDT KAGMFAGVDL LANIGKNDGS FMGKKYFQTE  60
   61 YPQSGLFIQL QKVASLIEKA SISQTSRRTT MEPLSIPKNR SIVRLTNQFS PMDDPKSPTP 120
  121 MRSFRITSRH SGNQQSMDQE ASDHHQQQEF GYDNREDRME VDSILSSDRK ANHNTTSDWK 180
  181 PDNGHMNDLN SSEVTIELRE AQLTIEKLQR KQLHYKRLLD DQRMVLEEVQ PTFDRYEATI 240
  241 QEREKEIDHL KQQLELERRQ QAKQKQFFDA ENEQLLAVVS QLHEEIKENE ERNLSHNQPT 300
  301 GANEDVELLK KQLEQLRNIE DQFELHKTKW AKEREQLKMH NDSLSKEYQN LSKELFLTKP 360
  361 QDSSSEEVAS LTKKLEEANE KIKQLEQAQA QTAVESLPIF DPPAPVDTTA GRQQWCEHCD 420
  421 TMGHNTAECP HHNPDNQQFF

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details (MIPS) Mewes HW, et al. (2004) AME1 ARP1 ASE1 ATG4 ATG8 BIK1 BIM1 CBF5 CIK1 CIN2 CIN4 DYN1 JNM1 KAR3 KAR5 MHP1 NUF2 RBL2 SPC19 SPC34 SPC98 STU1 STU2 TID3 YTM1
    View Details Krogan NJ, et al. (2006) BIK1 ERG29 PKH3 RTR1 STB4
    View Details Ho Y, et al. (2002) AMS1 BIK1 CPR1 HHT1, HHT2 HTB1 LAP4 VMA4
    View Details Qiu et al. (2008) ASE1 ATG8 BIK1 BIM1 BNI1 BUB1 CIK1 CIN8 DAD4 DYN1 HSK3 KAR3 KAR9 KIP1 KIP2 KIP3 NIP100 NUF2 NUM1 SLK19 SPC110 SPC19 SPC24 SPC34 SPC72 STU1 STU2 TID3 TUB3 TUB4 VRP1

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data BIK1 Huh WK, et al. (2003)
    View Data BIK1 and SPC42 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..60] PSI-BLAST 52.67837 Cytoskeleton-associated protein F53F4.3
    2 View Details [61..440] PSI-BLAST 17.522879 Heavy meromyosin subfragment


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle