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Protein Overview: STU2

General Information:
Name(s) found: STU2 / YLR045C [SGD]
Description(s) found:
Found 28 descriptions.
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  • Microtubule-associated protein (MAP) of the XMAP215/Dis1 family; regulates microtubule dynamics during spindle orientation and metaphase chromosome alignment; interacts with spindle pole body component Spc72p [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 888 amino acids

    Gene Ontology:
    Cellular Component: spindle microtubule [IDALink to PubMed article]
    cell cortex [IDALink to PubMed article]
    spindle pole body [IDALink to PubMed article]
    condensed nuclear chromosome kinetochore [IDALink to PubMed article]
    kinetochore [IDALink to PubMed article]
    Biological Process: microtubule nucleation [IPILink to PubMed article]
    mitotic spindle organization in nucleus [IGILink to PubMed article]
    Molecular Function: structural constituent of cytoskeleton [IPILink to PubMed article]
    microtubule binding [IMPLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSGEEEVDYT TLPLEERLTY KLWKARLEAY KELNQLFRNS VGDISRDDNI QIYWRDPTLF  60
   61 AQYITDSNVV AQEQAIVALN SLIDAFASSS LKNAHNITLI STWTPLLVEK GLTSSRATTK 120
  121 TQSMSCILSL CGLDTSITQS VELVIPFFEK KLPKLIAAAA NCVYELMAAF GLTNVNVQTF 180
  181 LPELLKHVPQ LAGHGDRNVR SQTMNLIVEI YKVTGNNSDL LEEILFKKLK PIQVKDLHKL 240
  241 FAKVGDEPSS SKMLFEWEKR ELEKKRSQEE EARKRKSILS NDEGEYQIDK DGDTLMGMET 300
  301 DMPPSKQQSG VQIDTFSMLP EETILDKLPK DFQERITSSK WKDRVEALEE FWDSVLSQTK 360
  361 KLKSTSQNYS NLLGIYGHII QKDANIQAVA LAAQSVELIC DKLKTPGFSK DYVSLVFTPL 420
  421 LDRTKEKKPS VIEAIRKALL TICKYYDPLA SSGRNEDMLK DILEHMKHKT PQIRMECTQL 480
  481 FNASMKEEKD GYSTLQRYLK DEVVPIVIQI VNDTQPAIRT IGFESFAILI KIFGMNTFVK 540
  541 TLEHLDNLKR KKIEETVKTL PNFSIASGST HSTIETNKQT GPMENKFLLK KSSVLPSKRV 600
  601 ASSPLRNDNK SKVNPIGSVA SASKPSMVAA NNKSRVLLTS KSLATPKNVV ANSTDKNEKL 660
  661 IEEYKYRLQK LQNDEMIWTK ERQSLLEKMN NTENYKIEMI KENEMLREQL KEAQSKLNEK 720
  721 NIQLRSKEID VNKLSDRVLS LENELRNMEI ELDRNKKRND TNLQSMGTIS SYSIPSSTVS 780
  781 SNYGVKSLSS ALPFKEEEDV RRKEDVNYER RSSESIGDLP HRVNSLNIRP YRKNGTGVSS 840
  841 VSDDLDIDFN DSFASEESYK RAAAVTSTLK ARIEKMKAKS RREGTTRT

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details (MIPS) Mewes HW, et al. (2004) AME1 ARP1 ASE1 ATG4 ATG8 BIK1 BIM1 CBF5 CIK1 CIN2 CIN4 DYN1 JNM1 KAR3 KAR5 MHP1 NUF2 RBL2 SPC19 SPC34 SPC98 STU1 STU2 TID3 YTM1
    View Details Krogan NJ, et al. (2006) STU2 TUB1 TUB3
    View Details Qiu et al. (2008) AME1 ARP1 ARP10 ASE1 ATG4 BBP1 BIK1 CIK1 CIN8 CNM67 DYN1 HSK3 IQG1 KAR3 KAR9 KIP1 KIP2 MPS2 NDC1 NIP100 NNF1 NUF2 NUM1 SGO1 SLK19 SPA2 SPC105 SPC110 SPC19 SPC24 SPC25 SPC29 SPC34 SPC42 SPC72 SPC97 SPC98 STU1 STU2 TID3 TUB1 TUB2 TUB3 TUB4

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run BOI1 Sample bob1 (2nd set) from october 2005 McCusker D, et al (2007)
    View Run MLP2 #19 Asynchronous Prep1-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)
    View Run MLP2 #24 Asynchronous Prep3-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)
    View Run MLP2 #32 Asynchronous Prep-No Phosphopeptide enrichment Keck JM, et al. (2011)
    View Run MLP2 #29 Asynchronous Prep5-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #10 Mitotic Prep1-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)
    View Run MLP2 #19b Asynchronous Prep1-new search criteria Keck JM, et al. (2011)
    View Run None Entered #17 Mitotic Prep3-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)
    View Run MLP2 #19a Asynchronous Prep1-new search criteria Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data STU2 and SPC42 Huh WK, et al. (2003)
    View Data STU2 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..155] PSI-BLAST 62.69897 Constant regulatory domain of protein phosphatase 2a, pr65alpha
    2 View Details [156..330] PSI-BLAST 62.69897 Constant regulatory domain of protein phosphatase 2a, pr65alpha
    3 View Details [331..561] PSI-BLAST 62.69897 Constant regulatory domain of protein phosphatase 2a, pr65alpha
    4 View Details [562..755] MSA 1.048982 View MSA. No confident structure predictions are available.
    5 View Details [756..888] deduced N/A No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • protein transporter activity
    		•  3.05338750264476 bayes_pls_golite062009
  • binding
    		•  2.86831493830281 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  2.61566088685247 bayes_pls_golite062009
  • actin binding
    		•  1.76244772281676 bayes_pls_golite062009
  • protein binding
    		•  1.63705839411934 bayes_pls_golite062009
  • transporter activity
    		•  1.55621630624352 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  1.33334123659384 bayes_pls_golite062009
  • protein transmembrane transporter activity
    		•  1.15447282085461 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.804909841250605 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  0.350388174853674 bayes_pls_golite062009
  • signal sequence binding
    		•  0.27824906981293 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  0.141331164449492 bayes_pls_golite062009
  • transcription regulator activity
    		•  0.123389318446902 bayes_pls_golite062009
  • DNA binding
    		•  0.089209424262799 bayes_pls_golite062009
  • RNA binding
    		•  0.0370585094254798 bayes_pls_golite062009
    2 No functions predicted.
    3 No functions predicted.
    4 No functions predicted.
    5 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.93

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle