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Protein Overview: ASE1

General Information:
Name(s) found: ASE1 / YOR058C [SGD]
Description(s) found:
Found 33 descriptions.
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  • Mitotic spindle midzone localized microtubule-associated protein (MAP) family member; required for spindle elongation and stabilization; undergoes cell cycle-regulated degradation by anaphase promoting complex; potential Cdc28p substrate [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 885 amino acids

    Gene Ontology:
    Cellular Component: spindle midzone [IDALink to PubMed article]
    spindle [IDALink to PubMed article]
    nuclear microtubule [IDALink to PubMed article]
    Biological Process: mitotic spindle elongation [IGILink to PubMed article][IMPLink to PubMed article]
    microtubule bundle formation [IDALink to PubMed article]
    mitotic anaphase B [TASLink to PubMed article]
    mitotic spindle organization in nucleus [TASLink to PubMed article]
    mitotic spindle stabilization [IMPLink to PubMed article]
    Molecular Function: microtubule binding [IDALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 METATSSPLP IKSRRNSENS GSTTVIPHMN PSLATPLTVS TMVNQSNSKE FMKLTPVRIR  60
   61 DFGSPLKNVS TNYHFLDSEN GKGNTMDNMY RENFILISKD LEKLLENLNV IYQNIGYSNT 120
  121 EIITKEKIIF TTISNSIKQF FEQADEELKR LSAENGIEQD ILNNILERIN DPSGIKTIPD 180
  181 LYIRNAILLQ ESKTVPQSPK KPLSLLSKKA ALDTAKKFVL GSFLPRLRDY LKSLITLKHL 240
  241 IQSVKENLPG LTEADNEAIA EFPELSTLTA YLLQIENGKG DIGLSMKFII DNRKDILKGS 300
  301 AFKTINEESV KHMNEVIKIY EEEYERRFKS VLTKKVSISS ICEQLGTPLA TLIGEDFEQD 360
  361 LRSYGEEENS TSEIPNFHPV DRERMSKIDI TLEKLQAIHK ERADKKRLLM EQCQKLWTRL 420
  421 KISQEYIKTF MRNNSSLSTE SLGRISKEVM RLEAMKKKLI KKLISDSWDK IQELWRTLQY 480
  481 SEESRSKFII VFEELRNSAT TLQEDELLLE TCENELKRLE EKLTLYKPIL KLISDFESLQ 540
  541 EDQEFLERSS KDSSRLLSRN SHKILLTEEK MRKRITRHFP RVINDLRIKL EEADGLFDQP 600
  601 FLFKGKPLSE AIDIQQQEIE AKYPRCRVRM QRSKKGKCGA NKENKVIKNT FKATESSIRV 660
  661 PIGLNLNDAN ITYKTPSKKT IQGLTKNDLS QENSLARHMQ GTTKLSSPNR RATRLLAPTV 720
  721 ISRNSKGNIE RPTLNRNRSS DLSSSPRINH THGEHAVKPR QLFPIPLNKV DTKGSHIPQL 780
  781 TKEKALELLK RSTGTTGKEN VRSPERKSSL EDYAQKLSSP YKEPEHSIYK LSMSPEGKFQ 840
  841 LNIQQKDIES GFDDTSMMED ENDKDFITWK NEQVSKLNGF SFTDI

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) ABF2 ASE1 CRN1 HSP60 RPL26A
    View Details (MIPS) Mewes HW, et al. (2004) ASE1 ATG4 ATG8 BIK1 BIM1 CBF5 CIN2 CIN4 MHP1 RBL2 SPC98 STU1 STU2 YTM1
    View Details Krogan NJ, et al. (2006) ASE1 RPS25B STM1 VTS1 YPL150W
    View Details Qiu et al. (2008) ASE1 ATG4 BIK1 DAD3 DAD4 HSK3 STU1 STU2

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run CEP3 sample cbf3 from feb 2005 Sandall S, et all (2006)
    View Run MLP2 #12 Mitotic Prep1-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #30 Asynchronous Prep6-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data ASE1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..298] MSA 34.365997 View MSA. No confident structure predictions are available.
    2 View Details [299..746] PSI-BLAST 13.154902 Heavy meromyosin subfragment
    3 View Details [747..885] deduced N/A No confident structure predictions are available.
    4 View Details [737..885] deduced N/A No confident structure predictions are available.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.97

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle