Protein Overview: BIM1

General Information:
Name(s) found:	BIM1 / YER016W [SGD]
Description(s) found: Found 21 descriptions. SHOW ALL	Microtubule-binding protein that together with Kar9p makes up the cortical microtubule capture site and delays the exit from mitosis when the spindle is oriented abnormally [SGD]
Organism:	Saccharomyces cerevisiae
Length:	344 amino acids
Gene Ontology:
Cellular Component:	spindle pole body [IDA] kinetochore [TAS] cytoplasmic microtubule [IDA]
Biological Process:	mitotic cell cycle spindle assembly checkpoint [TAS] microtubule nucleation [IPI] mitotic sister chromatid cohesion [IGI][IMP] nuclear migration along microtubule [IMP] negative regulation of microtubule depolymerization [IMP] microtubule depolymerization [IMP]
Molecular Function:	structural constituent of cytoskeleton [IPI]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSAGIGESRT ELLTWLNGLL NLNYKKIEEC GTGAAYCQIM DSIYGDLPMN RVKFNATAEY  60
   61 EFQTNYKILQ SCFSRHGIEK TVYVDKLIRC KFQDNLEFLQ WLKKHWIRHK DESVYDPDAR 120
  121 RKYRPIITNN SATKPRTVSN PTTAKRSSST GTGSAMSGGL ATRHSSLGIN GSRKTSVTQG 180
  181 QLVAIQAELT KSQETIGSLN EEIEQYKGTV STLEIEREFY FNKLRDIEIL VHTTQDLINE 240
  241 GVYKFNDETI TGHGNGNGGA LLRFVKKVES ILYATAEGFE MNDGEDELND KNLGEHGTVP 300
  301 NQGGYANSNG EVNGNEGSNH DVIMQNDEGE VGVSNNLIID EETF

Protein Complex Data

	PUBLICATION	TOPOLOGY	COCOMPLEXED PROTEINS
View Details	(MIPS) Mewes HW, et al. (2004)		ASE1 ATG4 ATG8 BIK1 BIM1 CBF5 CIN2 CIN4 MHP1 RBL2 SPC98 STU1 STU2 YTM1
View Details	Krogan NJ, et al. (2006)		BIM1 BMH1 GTS1 HAP1 RCN2 SFL1
View Details	Qiu et al. (2008)		ARP1 BIK1 BIM1 CIK1 DYN3 HSK3 JNM1 KAR3 KIP2 KIP3 MHP1 PAC1 SPC19 SPC34 STU1 TUB1 TUB2 TUB3

Mass Spectrometry Data

The following runs contain data for this protein:

	BAIT	COMMENTS	PUBLICATION
View Run	BIM1	No Comments	Cheeseman IM, et al. (2002)

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

	BAIT	PREY	HITS	PUBLICATION
View Screen	PRE4	BIM1	2	Unpublished Fields Lab Data

Microscopy / Localization Data

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	PROTEIN(S)	PUBLICATION
View Data	BIM1	Huh WK, et al. (2003)

Protein Structure Data

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[View Top Sequence Alignments] [Show Ginzu Version Information]

Domains predicted:

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..122]	Pfam	6.853872	Calponin homology (CH) domain No confident structure predictions are available.
2	View Details	[123..188]	deduced	N/A	No confident structure predictions are available.
3	View Details	[189..344]	Pfam	24.200659	EB1-like C-terminal motif No confident structure predictions are available.

Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

Philius Transmembrane Prediction:

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.99

Source: Reynolds et al. (2008)

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2