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Protein Overview: MHP1

General Information:
Name(s) found: MHP1 / YJL042W [SGD]
Description(s) found:
Found 25 descriptions.
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  • Microtubule-associated protein involved in assembly and stabilization of microtubules; overproduction results in cell cycle arrest at G2 phase; similar to Drosophila protein MAP and to mammalian MAP4 proteins [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 1398 amino acids

    Gene Ontology:
    Cellular Component: microtubule [IDALink to PubMed article]
    Biological Process: cellular cell wall organization [IMPLink to PubMed article]
    negative regulation of microtubule depolymerization [IMPLink to PubMed article]
    Molecular Function: structural constituent of cytoskeleton [IDALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDSKDTQKLL KEHRIPCIDV GWLVRPSAST SKSSRPGKSE SKANSVAPDI QMDTARPPVF  60
   61 ETSVDSSSSI LSSNDKGRRH SVAASLLMDN QRANAGSTSV PTNIPPPRGR SKSVVETNLS 120
  121 NVEADSGHHH HHRHHHHTED APAPKKVGFF KSLFGHRKKD QEQQEKERER KERSPSPTHV 180
  181 DRGAAIRRER TATISAESPP PLQYNAPPSY NDTVVPLTRS KTESEVYYEN HPQSYYHGRM 240
  241 RTYHSPEEGK VDGTSPADDH NYGGSRPDPR LMDFLRYYKS KDYKLAAFKE GNFIKSSASP 300
  301 TTKKNRRASF SLHNDKPQPA KSLAHQKFDA KGRPIPPHPD APKLPSAFRK KHPSNASIVD 360
  361 TVDSNSDVSS SAQNNNQTPS SHKFGAFLRK VTSYGNNNNN STNASSLSAN VNNPDTSSTS 420
  421 LWSSSSMEFD PSKITTVPGL ENIRPLKHVS FATNTYFNDP PQQICSKNPR KGEVEVKPNG 480
  481 SVVIHRLTPQ ERKKIMESTS LGVVVGGTGQ LKLLNPEEDD ANAKSKEEMA PQKQNEVEAH 540
  541 DEEDNNSQRR NIVMAAAEAA AEARAKEAPN ELKRIVTNNE EEVTVSKTAS HLTIDKPMIS 600
  601 RRGASTSSLA SMVSSDTNGT NADDEGEILP PPSLKIPHDI VYTRCCHLRE ILPIPATLKQ 660
  661 LKKGSTDPIP ILQLRNPRPS MVEIWSFSDF LSIAPVLCLS LDGVQLTVQM LRIILSSLVY 720
  721 KQHFQKLSLR NTPLDEEGWK VLCYFVSKAK SLHSIDLTMV PSIKTNVQKP SKSSLKSKIL 780
  781 RMQCNLENRS DMNWDLLTAS IALMGGLEEI VISGAKMNSA QFKNFILVAC IATERLGLAY 840
  841 NGLSKSQCDD LAKWMVQSKV TGLDVGFNDL NGKLSSFTDA VLGKIQKANE KNVFKFLSLN 900
  901 GTNLRVNEHD TFENNEVLKL ISVLCYLENL KFLDISNNPA IFPHCVPTLI DFLPVFVNLV 960
  961 RLHIDYNNLS STSVVMLAEI LPMCSRLNYF SMLGTELDLA SSKALAEAVR KSSSLMTLDV1020
 1021 DYVYMPENIK EKISLYALRN IQGELKRVNS DDKDIKDSQF SSLQDQLSLL LTEKADNSEH1080
 1081 YNKMVENFMA KIALARIKIS KVVHDLFDLK LNGQLNLEGK EALIRLCFIE ASLERGCDLL1140
 1141 KQRHNNTLKS PEAVSKSRKG GNQAQPNSES CQRMLLSSSI LQNSDHIALM PFGSAIVEKS1200
 1201 SPDAEDAVEF REGDDSNVNH EDVPANDQQF RDEVDIKNKY SIIKRELEHE KLVGGGDLPV1260
 1261 DKEILNRAAQ SLDSDQIKEF LLKNDVSTIL GVIDELHSQG YHLHHIFKKQ GNQEETAFRT1320
 1321 KDEQQSSQSN DSSANASPTT DPISTGSNTS RTNDNAHIPP TDAPGFDKFM NNAEENAIDA1380
 1381 AYDDVLDKIQ DARNSSTK

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details (MIPS) Mewes HW, et al. (2004) ASE1 ATG4 ATG8 BIK1 BIM1 CBF5 CIN2 CIN4 MHP1 RBL2 SPC98 STU1 STU2 YTM1
    View Details Ho Y, et al. (2002) CFT1 CIC1 CLU1 ERB1 FIN1 FIP1 FPR3 FPR4 GLC7 GLC8 GPH1 HER1 KEL1 MHP1 NSA1 REG1 RRP17 SCD5 SDS22 SEN1 SPB1 SUI2 SUI3 YTM1
    View Details Qiu et al. (2008) ARC40 BIM1 CNM67 DYN1 HSK3 KIP2 KIP3 MHP1 SPC19 SPC34 STU1 TUB1 TUB3

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run CEP3 sample cbf3 from feb 2005 Sandall S, et all (2006)
    View Run RPA135 No Comments Schneider, DA, et al. (2006)
    View Run ZDS1 Sample 3 - cpn + atp, from june 2005 McCusker D, et al (2007)
    View Run VAM3 Sample: HX11 - both fusion and trans-SNARE complex formation take place. Hao Xu, et al. (2010)
    View Run VAM3 Sample: HX12 - trans-SNARE complex formation and fusion are inhibited (control). Hao Xu, et al. (2010)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen CIT2 MHP1 2 Uetz P, et al. (2000)
    View Screen GLC7 MHP1 2 Uetz P, et al. (2000)
    View Screen DCN1 MHP1 2 Unpublished Fields Lab Data

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data MHP1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..677] MSA 65.409998 View MSA. No confident structure predictions are available.
    2 View Details [678..998] MSA 2.009997 View MSA. No confident structure predictions are available.
    3 View Details [999..1398] deduced N/A No confident structure predictions are available.
    4 View Details [414..1185] FFAS03 2.41 The molecular structure of toll-like receptor 3 ligand binding domain
    5 View Details [1186..1398] deduced N/A No confident structure predictions are available.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.97

    Source: Reynolds et al. (2008)

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