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Protein Overview: DCN1

General Information:
Name(s) found: DCN1 / YLR128W [SGD]
Description(s) found:
Found 28 descriptions.
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  • Scaffold-type E3 ligase required for cullin neddylation and ubiquitin ligase activation; contains a ubiquitin-binding domain (UBA) for ubiquitin and Nedd8 (Rub1p) interaction and a PONY domain involved in cullin binding and neddylation [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 269 amino acids

    Gene Ontology:
    Cellular Component: cellular_component [ND]
    Biological Process: positive regulation of ubiquitin-protein ligase activity [IMPLink to PubMed article][IPILink to PubMed article]
    protein neddylation [IDALink to PubMed article][IMPLink to PubMed article]
    Molecular Function: enzyme activator activity [IMPLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSNNKIKRKD ASPEQEAIES FTSLTKCDPK VSRKYLQRNH WNINYALNDY YDKEIGTFTD  60
   61 EVSTVAHPPV YPKELTQVFE HYINNNLFDI DSLVKFIEEL GYNLEDLATL CLAHLLGYKK 120
  121 LEEPLKREDF LSTWFMQGCS TISDMQECIK TLDVKLHEDL QYFTQIYNYA FNLILDPNRK 180
  181 DIDTDEGIQY WKLFFQPEYP VRMEPDLLEA WFRFLRDEGK TTISKDTWRM LLLFFKRYPT 240
  241 IQKIISDYDE TAAWPFIIDE FYECLQDQQ

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen DCN1 GMH1 2 Unpublished Fields Lab Data
    View Screen DCN1 DFG5 2 Unpublished Fields Lab Data
    View Screen DCN1 YNL247W 2 Unpublished Fields Lab Data
    View Screen DCN1 SMA1 2 Unpublished Fields Lab Data
    View Screen DCN1 KAR9 2 Unpublished Fields Lab Data
    View Screen CDC53 DCN1 2 Uetz P, et al. (2000)
    View Screen DCN1 RHB1 2 Unpublished Fields Lab Data
    View Screen DCN1 YIR014W 2 Unpublished Fields Lab Data
    View Screen DCN1 MHP1 2 Unpublished Fields Lab Data

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..124] deduced N/A No confident structure predictions are available.
    2 View Details [125..269] Pfam 68.075721 Domain of unknown function (DUF298) No confident structure predictions are available.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle