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Protein Overview: HER1

General Information:
Name(s) found: HER1 / YOR227W [SGD]
Description(s) found:
Found 26 descriptions.
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  • Protein of unknown function required for proliferation or remodeling of the ER that is caused by overexpression of Hmg2p; may interact with ribosomes, based on co-purification experiments [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 1246 amino acids

    Gene Ontology:
    Cellular Component: cytoplasm [IDALink to PubMed article]
    mitochondrion [IDALink to PubMed articleLink to PubMed article]
    ribosome [IDALink to PubMed article]
    Biological Process: biological_process [ND]
    Molecular Function: molecular_function [ND]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSSKLKYTDI DVPLDWLYKG KRRNRTKSAA STRTSEATTT SVKKTATLPS TAAVPTKTIA  60
   61 SPQRPLSGQN VNNELSNSKP AVSAEKVSQQ GQVPTRRTRS HSVSYGLLQK KNNNDDTTDS 120
  121 PKISRIRTAQ DQPVKETKSS TLAEPIVSKK GRSRSSSIST SLNERSKKSL FGSLFGRRPS 180
  181 TTPSHVVERP LSSQNDHKKS TELPPIDTRQ SKISTPTSTP TTASSKPSSS GGNRHSDGSL 240
  241 TSKLLSIPHN ILETSSTNFN AHHHIQSHHS SGREQDSPHS ESSDLPPILE KETTQKQLQK 300
  301 VSKVNLKRVT IAVQEFNSDP PQQLPSRKPK RGNVLIPEDM ISAPPLISLG ITNSSDQSSF 360
  361 QSNISPSYSK DSKEYKLALE NFKKAAKEAE KHQKDAYYVA ERMAQEVANY KARQLKTSPL 420
  421 TGATNSAADS ATDQESSSLD ARASKLHIDK PINVGAHPFE THQDDNIKYS SHLEQTLDVA 480
  481 YTRCCHLREI LPIPSTLRQV KGKTAPLQTL KFLNPKPTLV DILSFCDFIA ITPIHNIIFD 540
  541 NVSLTHDMFK IVICSLVTSP VVEKLGLRNV VINEQSWKLL CKFLLQNKTL IKLDISQTKA 600
  601 RTDLNDSNYR DQMDWELFCE VLRNREGRPL EELLLNGLRF DKMSFSHFKN ILLTFAQMNP 660
  661 KNPIRLGMAN VEFSTECFDF LFNWMSEYNV QGVDLAYNNL ESLAKRMIKK LARLPYKHLE 720
  721 YFTLNSTNIT SVDDMSYILK YLSRLPSIKF LDLSNLPQLF PGILTSGYKY FPQFPQLKRI 780
  781 HFDFDDLSIK ETTMLVSILA KCETLSHVSL IGQSPMPDAS KISDSTDEPD KSKDEKKEQI 840
  841 VFMRNTLWAS LYAFVRDSHN LVSLDVDYDQ VPDEIQSRIA LCLMHNMKRI MDSSFKLDEL 900
  901 TVQDDLIFDG SLITETAEEV LKRLNDKSLL QNDVGKKYLL KKYFEKMEKV HHNVQNTIDS 960
  961 MFEKRKSGEL PLQEKENLLR LLLLEKNLSN ILDIFASMPN IADVVPFSKA DNSFPNIGDS1020
 1021 TVSANYNDGI RPSLKHLDSD RLINDVSIPE NDSSIRPHLM ATDSGRIIDV TTGKALLFKS1080
 1081 SSNTSLAGKR QEEEEGELHK WGVFVQHQSS RHNSGLPSSA NSSRISGSLT PDSSVAGGKK1140
 1141 GESSRTSGTR PKILPKIPTG AELRDAIIKA KGIDSVDDLI KNVTSEKVGL ESLYGDELNS1200
 1201 RSPSNDSLQE SQQKAPLQRP LVEDETVTKK YDKLLNDLSN VRHSKT

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Krogan NJ, et al. (2006) BNI4 BUD14 GIP3 GLC7 GLC8 HER1 PPZ1 PUF3 SDS22 SOL1 SOL2 YLR257W YPI1
    View Details Gavin AC, et al. (2002) ARX1 BEM2 BMS1 BRX1 BUD20 CIC1 CLU1 CYR1 CYS4 DBP10 DBP9 DCP2 DRS1 EBP2 ERB1 FPR4 GCN1 HAS1 HDA1 HER1 HIS3 INP2 IPI1 IPI3 KRE33 LHP1 LOC1 LSG1 MAK21 MAK5 MDN1 MIS1 MRT4 NAP1 NIP1 NIP7 NMD3 NOC2 NOC3 NOG1 NOG2 NOP1 NOP12 NOP15 NOP16 NOP2 NOP4 NOP56 NOP7 NSA1 NSA2 NUG1 PRT1 PUF6 REI1 RIX1 RIX7 RLP24 RLP7 RPA135 RPA190 RPF1 RPF2 RPG1 RPP2B RPT6 RRP1 RRP12 RSA3 RSA4 RTR1 SDA1 SEC7 SKI2 SNU13 SPB1 SPB4 SSF1 TIF6 TUB3 URB1 UTP10 UTP20 UTP22 YGL036W YTM1
    View Details Ho Y, et al. (2002) CFT1 CIC1 CLU1 ERB1 FIN1 FIP1 FPR3 FPR4 GLC7 GLC8 GPH1 HER1 KEL1 MHP1 NSA1 REG1 RRP17 SCD5 SDS22 SEN1 SPB1 SUI2 SUI3 YTM1

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run MLP2 #21 Asynchronous Prep2-IMAC Phosphopeptide enrichment A1 Keck JM, et al. (2011)
    View Run MLP2 #32 Asynchronous Prep-No Phosphopeptide enrichment Keck JM, et al. (2011)
    View Run MLP2 #03 Alpha Factor Prep1-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #12 Mitotic Prep1-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #11 Mitotic Prep1-TiO2 enriched, new search criteria Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data HER1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..223] ab initio 11.93 No description for 1deqA was found.
    2 View Details [224..292] deduced N/A No confident structure predictions are available.
    3 View Details [293..513] MSA 6.442995 View MSA. No confident structure predictions are available.
    4 View Details [514..597] PSI-BLAST 8.09691 Ribonuclease inhibitor
    5 View Details [598..639] PSI-BLAST 8.09691 Ribonuclease inhibitor
    6 View Details [640..869] PSI-BLAST 8.09691 Ribonuclease inhibitor
    7 View Details [870..966] PSI-BLAST 4.09691 Leucine rich effector protein YopM
    8 View Details [967..1246] ab initio 7.86 No description for 1l2qA was found.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle