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Protein Overview: CFT1

General Information:
Name(s) found: CFT1 / YDR301W [SGD]
Description(s) found:
Found 27 descriptions.
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  • RNA-binding subunit of the mRNA cleavage and polyadenylation factor; involved in poly(A) site recognition and required for both pre-mRNA cleavage and polyadenylation, 51% sequence similarity with mammalian AAUAA-binding subunit of CPSF [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 1357 amino acids

    Gene Ontology:
    Cellular Component: mRNA cleavage and polyadenylation specificity factor complex [IPILink to PubMed articleLink to PubMed article]
    mitochondrion [IDALink to PubMed articleLink to PubMed article]
    mRNA cleavage factor complex [IPILink to PubMed article]
    Biological Process: termination of RNA polymerase II transcription [IMPLink to PubMed article]
    mRNA polyadenylation [IDALink to PubMed article][TASLink to PubMed article]
    mRNA cleavage [IDALink to PubMed article][TASLink to PubMed article]
    Molecular Function: RNA binding [IDALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNVYDDVLDA TVVSHSLATH FTTSDYEELL VVRTNILSVY RPTRDGKLYL TDEFKFHGLI  60
   61 TDIGLIPQKD SPLSCLLLCT GVAKISILKF NTLTNSIDTL SLHYYEGKFK GKSLVELAKI 120
  121 STLRMDPGSS CALLFNNDII AFLPFHVNKN DDDEEEEDED ENIDDSELIH SMNQKSQGTN 180
  181 TFNKRKRTKL GDKFTAPSVV LVASELYEGA KNIIDIQFLK NFTKPTIALL YQPKLVWAGN 240
  241 TTISKLPTQY VILTLNIQPA ESATKIESTT IAFVKELPWD LHTIVPVSNG AIIVGTNELA 300
  301 FLDNTGVLQS TVLLNSFADK ELQKTKIINN SSLEIMFREK NTTSIWIPSS KSKNGGSNND 360
  361 ETLLLMDLKS NIYYIQMEAE GRLLIKFDIF KLPIVNDLLK ENSNPKCITR LNATNSNKNM 420
  421 DLFIGFGSGN ALVLRLNNLK STIETREAHN PSSGTNSLMD INDDDDEEMD DLYADEAPEN 480
  481 GLTTNDSKGT VETVQPFDIE LLSSLRNVGP ITSLTVGKVS SIDDVVKGLP NPNKNEYSLV 540
  541 ATSGNGSGSH LTVIQTSVQP EIELALKFIS ITQIWNLKIK GRDRYLITTD STKSRSDIYE 600
  601 SDNNFKLHKG GRLRRDATTV YISMFGEEKR IIQVTTNHLY LYDTHFRRLT TIKFDYEVIH 660
  661 VSVMDPYILV TVSRGDIKIF ELEEKNKRKL LKVDLPEILN EMVITSGLIL KSNMCNEFLI 720
  721 GLSKSQEEQL LFTFVTADNQ IIFFTKDHND RIFQLNGVDQ LNESLYISTY QLGDEIVPDP 780
  781 SIKQVMINKL GHDNKEEYLT ILTFGGEIYQ YRKLPQRRSR FYRNVTRNDL AITGAPDNAY 840
  841 AKGVSSIERI MHYFPDYNGY SVIFVTGSVP YILIKEDDST PKIFKFGNIP LVSVTPWSER 900
  901 SVMCVDDIKN ARVYTLTTDN MYYGNKLPLK QIKISNVLDD YKTLQKLVYH ERAQLFLVSY 960
  961 CKRVPYEALG EDGEKVIGYD ENVPHAEGFQ SGILLINPKS WKVIDKIDFP KNSVVNEMRS1020
 1021 SMIQINSKTK RKREYIIAGV ANATTEDTPP TGAFHIYDVI EVVPEPGKPD TNYKLKEIFQ1080
 1081 EEVSGTVSTV CEVSGRFMIS QSQKVLVRDI QEDNSVIPVA FLDIPVFVTD SKSFGNLLII1140
 1141 GDAMQGFQFI GFDAEPYRMI SLGRSMSKFQ TMSLEFLVNG GDMYFAATDA DRNVHVLKYA1200
 1201 PDEPNSLSGQ RLVHCSSFTL HSTNSCMMLL PRNEEFGSPQ VPSFQNVGGQ VDGSVFKIVP1260
 1261 LSEEKYRRLY VIQQQIIDRE LQLGGLNPRM ERLANDFYQM GHSMRPMLDF NVIRRFCGLA1320
 1321 IDRRKSIAQK AGRHAHFEAW RDIINIEFSM RSLCQGK

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) CFT1 CFT2 FIP1 GLC7 MPE1 PAP1 PFS2 PTA1 PTI1 REF2 RNA14 SSU72 SWD2 YSH1 YTH1
    View Details (MIPS) Mewes HW, et al. (2004) CFT1 CFT2 PTA1 YSH1
    View Details Krogan NJ, et al. (2006) AIM1 CFT1 CFT2 ECM21 FIP1 GIP4 MPE1 PAP1 PFS2 PTA1 PTI1 REF2 SSU72 SWD2 SYC1 YBL010C YLR358C YSH1 YTH1
    View Details Gavin AC, et al. (2006) CFT1 CFT2 FIP1 MPE1 PAP1 PFS2 PTA1 YSH1 YTH1
    View Details Gavin AC, et al. (2002) ACT1 AIM31 CFT1 CFT2 CKA1 CLP1 ENO2 FIP1 GLC7 HHF1, HHF2 HTA1 MPE1 PAP1 PCF11 PFK1 PFS2 PTA1 PTI1 REF2 RNA14 RNA15 RSA3 SEC13 SEC31 SSA3 SSU72 SYC1 TAF6 TIF4632 TYE7 VID24 VMR1 VPS53 YCL046W YSH1 YTH1
    View Details Ho Y, et al. (2002) CCT5 CCT6 CFT1 CIC1 CLU1 ERB1 FIN1 FIP1 FPR3 FPR4 GLC7 GLC8 GPH1 HER1 HGH1 KEL1 MHP1 NSA1 PFS2 REG1 RRP17 SCD5 SDS22 SEN1 SPB1 SUI2 SUI3 TCP1 YTM1
    View Details Qiu et al. (2008) CFT1 CFT2 CLP1 FIP1 HRP1 MPE1 PAP1 PFS2 PTA1 PTI1 REF2 RNA14 RNA15 SSU72 SWD2 SYC1 YSH1 YTH1

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run RPA135 No Comments Schneider, DA, et al. (2006)
    View Run RLF2 phosphorylation data - cascade search Green EM, et al (2005)
    View Run BOI1 Sample boi 1 with ha tag from october 2005 McCusker D, et al (2007)
    View Run MLP2 #12 Mitotic Prep1-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #02 Alpha Factor Prep1-TiO2 enriched, new search criteria Keck JM, et al. (2011)
    View Run MLP2 #30 Asynchronous Prep6-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen APC9 CFT1 2 Unpublished Fields Lab Data

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data CFT1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..722] MSA 2.02988 View MSA. No confident structure predictions are available.
    2 View Details [723..986] deduced N/A No confident structure predictions are available.
    3 View Details [987..1357] Pfam 126.568636 CPSF A subunit region No confident structure predictions are available.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.98

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle