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Protein Overview: TAF6

General Information:
Name(s) found: TAF6 / YGL112C [SGD]
Description(s) found:
Found 37 descriptions.
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  • Subunit (60 kDa) of TFIID and SAGA complexes, involved in transcription initiation of RNA polymerase II and in chromatin modification, similar to histone H4 [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 516 amino acids

    Gene Ontology:
    Cellular Component: transcription factor TFIID complex [IDALink to PubMed article][TASLink to PubMed article]
    SLIK (SAGA-like) complex [IPILink to PubMed article]
    SAGA complex [IDALink to PubMed article]
    Biological Process: chromatin modification [TASLink to PubMed article]
    protein amino acid acetylation [IPILink to PubMed article]
    histone acetylation [TASLink to PubMed article]
    chromatin organization [IPILink to PubMed article]
    regulation of transcription involved in G1 phase of mitotic cell cycle [IPILink to PubMed articleLink to PubMed article]
    transcription initiation from RNA polymerase II promoter [TASLink to PubMed articleLink to PubMed articleLink to PubMed article]
    Molecular Function: general RNA polymerase II transcription factor activity [TASLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSTQQQSYTI WSPQDTVKDV AESLGLENIN DDVLKALAMD VEYRILEIIE QAVKFKRHSK  60
   61 RDVLTTDDVS KALRVLNVEP LYGYYDGSEV NKAVSFSKVN TSGGQSVYYL DEEEVDFDRL 120
  121 INEPLPQVPR LPTFTTHWLA VEGVQPAIIQ NPNLNDIRVS QPPFIRGAIV TALNDNSLQT 180
  181 PVTSTTASAS VTDTGASQHL SNVKPGQNTE VKPLVKHVLS KELQIYFNKV ISTLTAKSQA 240
  241 DEAAQHMKQA ALTSLRTDSG LHQLVPYFIQ FIAEQITQNL SDLQLLTTIL EMIYSLLSNT 300
  301 SIFLDPYIHS LMPSILTLLL AKKLGGSPKD DSPQEIHEFL ERTNALRDFA ASLLDYVLKK 360
  361 FPQAYKSLKP RVTRTLLKTF LDINRVFGTY YGCLKGVSVL EGESIRFFLG NLNNWARLVF 420
  421 NESGITLDNI EEHLNDDSNP TRTKFTKEET QILVDTVISA LLVLKKDLPD LYEGKGEKVT 480
  481 DEDKEKLLER CGVTIGFHIL KRDDAKELIS AIFFGE

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) ADA2 GCN5 HFI1 NGG1 SGF11 SGF29 SGF73 SIN4 SPT15 SPT20 SPT3 SPT7 SPT8 SRB2 TAF1 TAF10 TAF11 TAF12 TAF3 TAF4 TAF5 TAF6 TAF7 TAF9 TRA1 UBP8
    View Details (MIPS) Mewes HW, et al. (2004) ADA2 GCN5 HFI1 NGG1 SGF29 SGF73 SPT20 SPT3 SPT7 SPT8 TAF1 TAF10 TAF11 TAF12 TAF13 TAF14 TAF2 TAF3 TAF5 TAF6 TAF7 TAF9 TRA1
    View Details Krogan NJ, et al. (2006) ADA2 AHC1 AHC2 ALD4 FMP40 GCN5 HFI1 KAP104 MSS4 NGG1 PDR15 RAD59 REV3 SGF11 SGF29 SGF73 SNL1 SPT20 SPT3 SPT7 SPT8 TAF1 TAF10 TAF11 TAF12 TAF13 TAF3 TAF4 TAF5 TAF6 TAF7 TAF9 TDA5 UBP8 YMR007W
    View Details Gavin AC, et al. (2002) ACT1 ADA2 ADH1 AIM31 CFT1 CFT2 CKA1 CLP1 CLU1 COG3 CSE2 ENO2 FAB1 FBA1 FIP1 FUN19 GAL11 GCN1 GCN5 GLC7 HEM13 HFI1 HHF1, HHF2 HTA1 ISW1 KAP114 KAP123 MED1 MED11 MED2 MED4 MED6 MED7 MED8 MES1 MLP1 MNN4 MOT1 MPE1 MRPL6 MYO1 MYO4 NGG1 NOP1 NUT1 NUT2 PAP1 PCF11 PDC1 PFK1 PFK2 PFS2 PGD1 PGK1 PSK1 PTA1 PTC1 PTI1 PUF6 REF2 RGR1 RNA14 RNA15 ROX3 RPB2 RPG1 RPN9 RPO21 RPT5 RSA3 RVB2 SEC13 SEC31 SGF29 SGF73 SIN3 SIN4 SPT15 SPT20 SPT7 SPT8 SRB2 SRB4 SRB5 SRB6 SRB7 SRB8 SRP1 SSA3 SSE2 SSN2 SSN3 SSN8 SSU72 SYC1 TAF1 TAF10 TAF11 TAF12 TAF13 TAF14 TAF2 TAF3 TAF4 TAF5 TAF6 TAF7 TAF8 TAF9 TBF1 TEF4 TIF1, TIF2 TIF4632 TYE7 UBP8 VAS1 VID24 VMR1 VPS1 VPS53 YCL046W YEF3 YIL077C YSH1 YTH1
    View Details Ho Y, et al. (2002) ADA2 FET4 GCN5 HFI1 SGF29 SPT7 TAF6 TRA1 UBP8
    View Details Qiu et al. (2008) ADA2 CHD1 EPL1 GCN5 HFI1 MED8 NGG1 RGR1 SGF29 SGF73 SPT15 SPT20 SPT3 SPT7 SPT8 SRB6 SUS1 TAF1 TAF10 TAF11 TAF12 TAF13 TAF14 TAF2 TAF3 TAF4 TAF5 TAF6 TAF7 TAF8 TAF9 TFA1 TFB5 TOA2 TRA1

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run CEP3 sample cbf3 from feb 2005 Sandall S, et all (2006)
    View Run ZDS1 Sample 2- cpn2 from june 2005 McCusker D, et al (2007)
    View Run ZDS1 Sample 3 - cpn + atp, from june 2005 McCusker D, et al (2007)
    View Run BOI1 Sample boi 1 with ha tag from october 2005 McCusker D, et al (2007)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data TAF6 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..84] PSI-BLAST 79.221849 TAF(II)62
    2 View Details [85..194] deduced N/A No confident structure predictions are available.
    3 View Details [195..306]
    [475..516]    		 ORFEUS 7.22 p120GAP domain
    4 View Details [307..474] ORFEUS 7.22 p120GAP domain
    5 View Details [424..516] deduced N/A Confident ab initio structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • general RNA polymerase II transcription factor activity
    		•  9.25279783093877 bayes_pls_golite062009
  • lysine N-acetyltransferase activity
    		•  5.97252613675094 bayes_pls_golite062009
  • histone acetyltransferase activity
    		•  5.97252613675094 bayes_pls_golite062009
  • N-acetyltransferase activity
    		•  4.49886535711761 bayes_pls_golite062009
  • DNA binding
    		•  4.49118409263799 bayes_pls_golite062009
  • nucleic acid binding
    		•  4.35201412176948 bayes_pls_golite062009
  • N-acyltransferase activity
    		•  4.22222466548509 bayes_pls_golite062009
  • transcription regulator activity
    		•  4.08606081850613 bayes_pls_golite062009
  • transcription initiation factor activity
    		•  3.96621818094279 bayes_pls_golite062009
  • acetyltransferase activity
    		•  3.91614625961398 bayes_pls_golite062009
  • acyltransferase activity
    		•  3.38611688546892 bayes_pls_golite062009
  • transferase activity, transferring acyl groups other than amino-acyl groups
    		•  3.35015681315177 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  3.28941584139552 bayes_pls_golite062009
  • binding
    		•  3.27510691458843 bayes_pls_golite062009
  • transferase activity, transferring acyl groups
    		•  3.1782337747057 bayes_pls_golite062009
  • transcription factor activity
    		•  2.51581622888695 bayes_pls_golite062009
  • transcription activator activity
    		•  1.25487495162413 bayes_pls_golite062009
  • transcription factor binding
    		•  1.15204005455906 bayes_pls_golite062009
  • transcription coactivator activity
    		•  1.1297723528047 bayes_pls_golite062009
  • nucleotidyltransferase activity
    		•  1.10331930589736 bayes_pls_golite062009
  • protein binding
    		•  1.07873333188144 bayes_pls_golite062009
  • centromeric DNA binding
    		•  1.03586371237592 bayes_pls_golite062009
  • transcription cofactor activity
    		•  1.01502031330902 bayes_pls_golite062009
  • transcription repressor activity
    		•  0.72554769377984 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  0.437760073242714 bayes_pls_golite062009
  • histone binding
    		•  0.218942897869955 bayes_pls_golite062009
  • transferase activity
    		•  0.106182831892296 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  0.0852726470007639 bayes_pls_golite062009
  • transcription corepressor activity
    		•  0.0736756545988504 bayes_pls_golite062009
    2 No functions predicted.
    3 No functions predicted.
    4 No functions predicted.
    5 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.96

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle