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Protein Overview: TOA2

General Information:
Name(s) found: TOA2 / YKL058W [SGD]
Description(s) found:
Found 37 descriptions.
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  • TFIIA small subunit; involved in transcriptional activation, acts as antirepressor or as coactivator; homologous to smallest subunit of human and Drosophila TFIIA [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 122 amino acids

    Gene Ontology:
    Cellular Component: transcription factor TFIIA complex [IDALink to PubMed article]
    Biological Process: transcription initiation from RNA polymerase II promoter [IDALink to PubMed article]
    Molecular Function: general RNA polymerase II transcription factor activity [IDALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAVPGYYELY RRSTIGNSLV DALDTLISDG RIEASLAMRV LETFDKVVAE TLKDNTQSKL  60
   61 TVKGNLDTYG FCDDVWTFIV KNCQVTVEDS HRDASQNGSG DSQSVISVDK LRIVACNSKK 120
  121 SE

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) TOA1 TOA2
    View Details (MIPS) Mewes HW, et al. (2004) TOA1 TOA2
    View Details Krogan NJ, et al. (2006) RRT5 TOA1 TOA2
    View Details Gavin AC, et al. (2002) TOA1 TOA2
    View Details Qiu et al. (2008) SRB6 SSL2 TAF1 TAF6 TFA2 TFB5 TFG1 TFG2 TOA1 TOA2

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run CEP3 sample cbf3 from feb 2005 Sandall S, et all (2006)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data TOA2 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..57] PSI-BLAST 639.28043 Small chain TOA2, N-terminal domain; Small chain TOA2, C-terminal domain
    2 View Details [58..122] PSI-BLAST 639.28043 Small chain TOA2, N-terminal domain; Small chain TOA2, C-terminal domain

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • general RNA polymerase II transcription factor activity
    		•  10.9702263885595 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  5.06993130505706 bayes_pls_golite062009
  • transcription regulator activity
    		•  4.7915315980149 bayes_pls_golite062009
  • transcription activator activity
    		•  2.75298328621175 bayes_pls_golite062009
  • nucleic acid binding
    		•  2.26583234267697 bayes_pls_golite062009
  • DNA binding
    		•  2.12151270115091 bayes_pls_golite062009
  • transcription coactivator activity
    		•  2.10703866415858 bayes_pls_golite062009
  • binding
    		•  1.9212205923594 bayes_pls_golite062009
  • protein binding
    		•  1.54756881357956 bayes_pls_golite062009
  • transcription factor binding
    		•  1.31659763916181 bayes_pls_golite062009
  • transcription cofactor activity
    		•  1.15899255380593 bayes_pls_golite062009
    2 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle