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Protein Overview: TOA1

General Information:
Name(s) found: TOA1 / YOR194C [SGD]
Description(s) found:
Found 29 descriptions.
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  • TFIIA large subunit; involved in transcriptional activation, acts as antirepressor or as coactivator; homologous to largest and second largest subunits of human and Drosophila TFIIA [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 286 amino acids

    Gene Ontology:
    Cellular Component: transcription factor TFIIA complex [IDALink to PubMed article]
    Biological Process: transcription initiation from RNA polymerase II promoter [IDALink to PubMed article]
    Molecular Function: general RNA polymerase II transcription factor activity [IDALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSNAEASRVY EIIVESVVNE VREDFENAGI DEQTLQDLKN IWQKKLTETK VTTFSWDNQF  60
   61 NEGNINGVQN DLNFNLATPG VNSSEFNIKE ENTGNEGLIL PNINSNNNIP HSGETNINTN 120
  121 TVEATNNSGA TLNTNTSGNT NADVTSQPKI EVKPEIELTI NNANITTVEN IDDESEKKDD 180
  181 EEKEEDVEKT RKEKEQIEQV KLQAKKEKRS ALLDTDEVGS ELDDSDDDYL ISEGEEDGPD 240
  241 ENLMLCLYDK VTRTKARWKC SLKDGVVTIN RNDYTFQKAQ VEAEWV

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) TOA1 TOA2
    View Details (MIPS) Mewes HW, et al. (2004) TOA1 TOA2
    View Details Krogan NJ, et al. (2006) RRT5 TOA1 TOA2
    View Details Gavin AC, et al. (2002) TOA1 TOA2
    View Details Qiu et al. (2008) SSL1 TFA1 TFB5 TOA1 TOA2

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run CEP3 sample cbf3 from feb 2005 Sandall S, et all (2006)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..88] PSI-BLAST 181.38764 Large chain TOA1, N-terminal domain
    2 View Details [89..209] deduced N/A No confident structure predictions are available.
    3 View Details [210..286] PSI-BLAST 370.68867 Large chain TOA1, C-terminal domain


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle