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Protein Overview: SSL1

General Information:
Name(s) found: SSL1 / YLR005W [SGD]
Description(s) found:
Found 29 descriptions.
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  • Component of the core form of RNA polymerase transcription factor TFIIH, which has both protein kinase and DNA-dependent ATPase/helicase activities and is essential for transcription and nucleotide excision repair; interacts with Tfb4p [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 461 amino acids

    Gene Ontology:
    Cellular Component: holo TFIIH complex [IDALink to PubMed articleLink to PubMed article]
    nucleotide-excision repair factor 3 complex [IDALink to PubMed article]
    Biological Process: negative regulation of transcription from RNA polymerase II promoter, mitotic [TASLink to PubMed article]
    nucleotide-excision repair, DNA duplex unwinding [TASLink to PubMed article]
    nucleotide-excision repair [IDALink to PubMed article][TASLink to PubMed article]
    transcription initiation from RNA polymerase II promoter [TASLink to PubMed articleLink to PubMed article]
    Molecular Function: general RNA polymerase II transcription factor activity [TASLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAPVVISESE EDEDRVAITR RTKRQVHFDG EGDDRVDQQQ QQHSSSHRDR DKHVQRKKKK  60
   61 RLSNRNLQGS NGGYAWEDEI KRSWDLVKVD DEGDMASLVA SIVEARKKRT AKKNITPYQR 120
  121 GIIRSLILTL DCSEAMLEKD LRPNRHAMII QYAIDFVHEF FDQNPISQMG IIIMRNGLAQ 180
  181 LVSQVSGNPQ DHIDALKSIR KQEPKGNPSL QNALEMARGL LLPVPAHCTR EVLIVFGSLS 240
  241 TTDPGDIHQT IDSLVSEKIR VKVLGLSAQV AICKELCKAT NYGDESFYKI LLDETHLKEL 300
  301 FNEAVTPLPV NKINKGFTLV KMGFPTRIFE DTPTFCSCHS KLVYGGYFCP NCHSKVCSLP 360
  361 TVCPCCDLML ILSTHLARSY HHLMPLKTFA EVPTTEKFRS EDCFSCQSRF PILKNHKNGK 420
  421 LLTSSRYRCE DCKQEFCVDC DVFIHEILHN CPGCESKPVI T

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) SSL1 TFB1 TFB3 TFB4
    View Details (MIPS) Mewes HW, et al. (2004) CCL1 KIN28 RAD2 RAD3 SSL1 SSL2 TFB1 TFB2 TFB3 TFB4
    View Details Krogan NJ, et al. (2006) CCL1 ESP1 KIN28 RAD3 SSL1 TFB1 TFB3 TFB4
    View Details Gavin AC, et al. (2006) SSL1 TFB1 TFB4
    View Details Gavin AC, et al. (2002) CCL1 DCS2 DNA2 ECM29 FAP1 FPR1 KAP95 KIN28 MEC1 MPH1 MRPS28 MSH2 MSH6 PGK1 RAD23 RAD34 RAD4 RAD52 RFA1 RFA2 RPN10 RPN12 RPN3 RPN6 RPN8 RPN9 RPT2 RPT3 RPT6 SPT7 SRO7 SSL1 TFA1 TFB1 TFB3 TFB4 TIF6
    View Details Qiu et al. (2008) ABF1 CCL1 ELC1 KIN28 RAD14 RAD2 RAD3 SSL1 SSL2 TAF14 TFA2 TFB1 TFB2 TFB3 TFB4 TFB5 TFC4 TFG2 TOA1

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data SSL1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..116] deduced N/A No confident structure predictions are available.
    2 View Details [117..345] PSI-BLAST 19.69897 No description for 1a8x__ was found.
    3 View Details [346..461] PSI-BLAST 95.325697 TFIIH p44 subunit cysteine-rich domain

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • binding
    		•  2.75824485094584 bayes_pls_golite062009
  • nucleic acid binding
    		•  2.08531850924748 bayes_pls_golite062009
  • DNA binding
    		•  1.91667917801679 bayes_pls_golite062009
  • protein binding
    		•  1.53311876872122 bayes_pls_golite062009
  • protein complex binding
    		•  0.68878168136573 bayes_pls_golite062009
  • hydrolase activity
    		•  0.564965244474085 bayes_pls_golite062009
  • structure-specific DNA binding
    		•  0.450760554291027 bayes_pls_golite062009
  • protein dimerization activity
    		•  0.4223194470523 bayes_pls_golite062009
  • protein heterodimerization activity
    		•  0.32921284315242 bayes_pls_golite062009
    2 No functions predicted.
    3 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle