YRC Logo
PROTEIN SEARCH:
Descriptions Names[Advanced Search]

Protein Overview: TFB4

General Information:
Name(s) found: TFB4 / YPR056W [SGD]
Description(s) found:
Found 24 descriptions.
SHOW ALL
  • Subunit of TFIIH complex, involved in transcription initiation, similar to 34 kDa subunit of human TFIIH; interacts with Ssl1p [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 338 amino acids

    Gene Ontology:
    Cellular Component: holo TFIIH complex [IDALink to PubMed article][TASLink to PubMed article]
    Biological Process: negative regulation of transcription from RNA polymerase II promoter, mitotic [TASLink to PubMed article]
    transcription initiation from RNA polymerase II promoter [TASLink to PubMed articleLink to PubMed article]
    Molecular Function: general RNA polymerase II transcription factor activity [TASLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDAISDPTFK HARSRKQVTE ESPSLLTVII EIAPKLWTTF DEEGNEKGSI IKVLEALIVF  60
   61 LNAHLAFNSA NKVAVIAAYS QGIKYLYPES TSALKASESE NKTRSDLKII NSDMYRRFRN 120
  121 VDETLVEEIY KLFELEKKQI EQNSQRSTLA GAMSAGLTYV NRISKESVTT SLKSRLLVLT 180
  181 CGSGSSKDEI FQYIPIMNCI FSATKMKCPI DVVKIGGSKE STFLQQTTDA TNGVYLHVES 240
  241 TEGLIQYLAT AMFIDPSLRP IIVKPNHGSV DFRTSCYLTG RVVAVGFICS VCLCVLSIIP 300
  301 PGNKCPACDS QFDEHVIAKL KRKPVVPRLK AKKKVTKP

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) SSL1 TFB1 TFB3 TFB4
    View Details (MIPS) Mewes HW, et al. (2004) CCL1 KIN28 RAD3 SSL1 SSL2 TFB1 TFB2 TFB3 TFB4
    View Details Krogan NJ, et al. (2006) CCL1 ESP1 KIN28 RAD3 SSL1 TFB1 TFB3 TFB4
    View Details Gavin AC, et al. (2006) SSL1 TFB1 TFB4
    View Details Gavin AC, et al. (2002) CCL1 CDC48 DCS2 DNA2 ECM29 FAP1 FPR1 KAP95 KIN28 KRS1 MEC1 MPH1 MRPS28 MSH2 MSH6 PGK1 RAD23 RAD34 RAD4 RAD52 RFA1 RFA2 RPN10 RPN12 RPN3 RPN6 RPN8 RPN9 RPT2 RPT3 RPT6 SPT7 SRO7 SSL1 TFA1 TFB1 TFB3 TFB4 TIF6
    View Details Qiu et al. (2008) CCL1 RAD3 SSL1 SSL2 TAF11 TFA1 TFA2 TFB1 TFB2 TFB3 TFB4 TFB5

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run ZDS1 Sample 3 - cpn + atp, from june 2005 McCusker D, et al (2007)
    View Run None Entered #17 Mitotic Prep3-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data TFB4 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..338] Pfam 188.552842 Transcription factor Tfb4 No confident structure predictions are available.
    2 View Details [240..338] FFAS03 0.954 No description for 2ozyA was found.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • binding
    		•  2.68315152218267 bayes_pls_golite062009
  • nucleic acid binding
    		•  2.10023916482665 bayes_pls_golite062009
  • DNA binding
    		•  1.9295508897092 bayes_pls_golite062009
  • protein complex binding
    		•  1.65763332955233 bayes_pls_golite062009
  • protein binding
    		•  1.42792331963866 bayes_pls_golite062009
  • hydrolase activity
    		•  0.589248272940562 bayes_pls_golite062009
  • structure-specific DNA binding
    		•  0.446181458443121 bayes_pls_golite062009
  • protein dimerization activity
    		•  0.244402438311177 bayes_pls_golite062009
  • protein heterodimerization activity
    		•  0.114607758890868 bayes_pls_golite062009
  • catalytic activity
    		•  0.0380261580236634 bayes_pls_golite062009
    2 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.65

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle