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Protein Overview: SRO7

General Information:
Name(s) found: SRO7 / YPR032W [SGD]
Description(s) found:
Found 26 descriptions.
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  • Effector of Rab GTPase Sec4p, forms a complex with Sec4p and t-SNARE Sec9p; involved in exocytosis and docking and fusion of post-Golgi vesicles with plasma membrane; homolog of Sro77p and Drosophila lgl tumor suppressor [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 1033 amino acids

    Gene Ontology:
    Cellular Component: cytosol [IDALink to PubMed article]
    plasma membrane [IDALink to PubMed article]
    Biological Process: small GTPase mediated signal transduction [IPILink to PubMed article]
    Golgi to plasma membrane transport [IGILink to PubMed article][IPILink to PubMed article]
    exocytosis [IGILink to PubMed article]
    Molecular Function: SNARE binding [IPILink to PubMed article]
    Rab GTPase binding [IDALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MFGSKRLKNV KEAFKSLKGQ NSETPIENSK ASFKSKNSKT STISKDAKSS SSLKIPISSN  60
   61 NKNKIFSLAE TNKYGMSSKP IAAAFDFTQN LLAIATVTGE VHIYGQQQVE VVIKLEDRSA 120
  121 IKEMRFVKGI YLVVINAKDT VYVLSLYSQK VLTTVFVPGK ITSIDTDASL DWMLIGLQNG 180
  181 SMIVYDIDRD QLSSFKLDNL QKSSFFPAAR LSPIVSIQWN PRDIGTVLIS YEYVTLTYSL 240
  241 VENEIKQSFI YELPPFAPGG DFSEKTNEKR TPKVIQSLYH PNSLHIITIH EDNSLVFWDA 300
  301 NSGHMIMART VFETEINVPQ PDYIRDSSTN AAKISKVYWM CENNPEYTSL LISHKSISRG 360
  361 DNQSLTMIDL GYTPRYSITS YEGMKNYYAN PKQMKIFPLP TNVPIVNILP IPRQSPYFAG 420
  421 CHNPGLILLI LGNGEIETML YPSGIFTDKA SLFPQNLSWL RPLATTSMAA SVPNKLWLGA 480
  481 LSAAQNKDYL LKGGVRTKRQ KLPAEYGTAF ITGHSNGSVR IYDASHGDIQ DNASFEVNLS 540
  541 RTLNKAKELA VDKISFAAET LELAVSIETG DVVLFKYEVN QFYSVENRPE SGDLEMNFRR 600
  601 FSLNNTNGVL VDVRDRAPTG VRQGFMPSTA VHANKGKTSA INNSNIGFVG IAYAAGSLML 660
  661 IDRRGPAIIY MENIREISGA QSACVTCIEF VIMEYGDDGY SSILMVCGTD MGEVITYKIL 720
  721 PASGGKFDVQ LMDITNVTSK GPIHKIDAFS KETKSSCLAT IPKMQNLSKG LCIPGIVLIT 780
  781 GFDDIRLITL GKSKSTHKGF KYPLAATGLS YISTVEKNND RKNLTVIITL EINGHLRVFT 840
  841 IPDFKEQMSE HIPFPIAAKY ITESSVLRNG DIAIRVSEFQ ASLFSTVKEQ DTLAPVSDTL 900
  901 YINGIRIPYR PQVNSLQWAR GTVYCTPAQL NELLGGVNRP ASKYKESIIA EGSFSERSSD 960
  961 DNNANHPEHQ YTKPTRKGRN SSYGVLRNVS RAVETRWDAV EDRFNDYATA MGETMNEAVE1020
 1021 QTGKDVMKGA LGF

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Gavin AC, et al. (2006) RAD34 SRO7
    View Details Gavin AC, et al. (2002) AMS1 ASC1 CDC14 DHH1 DNA2 ECM29 FBA1 KAP95 MAF1 MEC1 MPH1 MRPS28 MSH2 MSH6 PGK1 RAD23 RAD34 RAD4 RAD52 RET1 RFA1 RFA2 RPA12 RPA135 RPA190 RPA43 RPA49 RPB10 RPB5 RPB8 RPC11 RPC17 RPC19 RPC25 RPC31 RPC34 RPC37 RPC40 RPC53 RPC82 RPN10 RPN12 RPN3 RPN6 RPN8 RPN9 RPO26 RPO31 RPT2 RPT3 RPT6 RSC8 SRO7 SSL1 TFA1 TFB1 TFB4

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run CEP3 sample cbf3 from feb 2005 Sandall S, et all (2006)
    View Run BOI1 Sample boi 1 with ha tag from october 2005 McCusker D, et al (2007)
    View Run MLP2 #12 Mitotic Prep1-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #30 Asynchronous Prep6-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data SRO7 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..338] PSI-BLAST 64.69897 Tup1, C-terminal domain
    2 View Details [339..451] PSI-BLAST 2.522879 TolB, C-terminal domain; TolB, N-terminal domain
    3 View Details [452..623] MSA 9.198996 View MSA. No confident structure predictions are available.
    4 View Details [624..714] MSA 3.379997 View MSA. Confident ab initio structure predictions are available.
    5 View Details [715..1033] MSA 1.15595 View MSA. No confident structure predictions are available.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.96

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle