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Protein Overview: RPA43

General Information:
Name(s) found: RPA43 / YOR340C [SGD]
Description(s) found:
Found 28 descriptions.
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  • RNA polymerase I subunit A43 [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 326 amino acids

    Gene Ontology:
    Cellular Component: DNA-directed RNA polymerase I complex [TASLink to PubMed article]
    Biological Process: transcription from RNA polymerase I promoter [TAS]
    ribosome biogenesis [RCALink to PubMed article]
    Molecular Function: DNA-directed RNA polymerase activity [TASLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSQVKRANEN RETARFIKKH KKQVTNPIDE KNGTSNCIVR VPIALYVSLA PMYLENPLQG  60
   61 VMKQHLNPLV MKYNNKVGGV VLGYEGLKIL DADPLSKEDT SEKLIKITPD TPFGFTWCHV 120
  121 NLYVWQPQVG DVLEGYIFIQ SASHIGLLIH DAFNASIKKN NIPVDWTFVH NDVEEDADVI 180
  181 NTDENNGNNN NEDNKDSNGG SNSLGKFSFG NRSLGHWVDS NGEPIDGKLR FTVRNVHTTG 240
  241 RVVSVDGTLI SDADEEGNGY NSSRSQAESL PIVSNKKIVF DDEVSIENKE SHKELDLPEV 300
  301 KEDNGSEIVY EENTSESNDG ESSDSD

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) RPA12 RPA135 RPA14 RPA190 RPA34 RPA43 RPA49 RPB10 RPB5 RPB8 RPC19 RPC40 RPO26
    View Details (MIPS) Mewes HW, et al. (2004) RPA12 RPA135 RPA14 RPA190 RPA34 RPA43 RPA49 RPB10 RPB5 RPB8 RPC10 RPC19 RPC40 RPO26
    View Details Krogan NJ, et al. (2006) BDP1 CDC14 COY1 FAR7 MAF1 RET1 RPA12 RPA135 RPA14 RPA190 RPA34 RPA43 RPA49 RPC10 RPC11 RPC17 RPC19 RPC25 RPC31 RPC34 RPC37 RPC40 RPC53 RPC82 RPO31 YDL144C YIR024C
    View Details Gavin AC, et al. (2006) RPA12 RPA190 RPA43 RPA49 RPC40
    View Details Gavin AC, et al. (2002) AMS1 ASC1 CDC14 DHH1 FBA1 MAF1 RET1 RPA12 RPA135 RPA190 RPA43 RPA49 RPB10 RPB5 RPB8 RPC11 RPC17 RPC19 RPC25 RPC31 RPC34 RPC37 RPC40 RPC53 RPC82 RPO26 RPO31 RSC8 SRO7
    View Details Ho Y, et al. (2002) RPA135 RPA190 RPA43 RPB5
    View Details Qiu et al. (2008) RET1 RPA12 RPA135 RPA14 RPA190 RPA34 RPA43 RPA49 RPB10 RPB11 RPB3 RPB5 RPB7 RPB8 RPC10 RPC19 RPC25 RPC31 RPC34 RPC37 RPC40 RPC82 RPO26

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run RPA135 his-HA tag on RPA135 Schneider, DA, et al. (2006)
    View Run RPA135 his-HA tag on RPA135 Schneider, DA, et al. (2006)
    View Run RPA135 his-HA tag on RPA135 Schneider, DA, et al. (2006)
    View Run RPA135 his-HA tag on RPA135 Schneider, DA, et al. (2006)
    View Run CEP3 sample cbf3 from feb 2005 Sandall S, et all (2006)
    View Run RPA135 No Comments Schneider, DA, et al. (2006)
    View Run MLP2 #32 Asynchronous Prep-No Phosphopeptide enrichment Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data RPA43 Huh WK, et al. (2003)
    View Data RPA43 and NOP56 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..183] MSA 7.011978 View MSA. No confident structure predictions are available.
    2 View Details [184..326] deduced N/A No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • RNA polymerase activity
    		•  8.49996804151214 bayes_pls_golite062009
  • DNA-directed RNA polymerase activity
    		•  8.49996804151214 bayes_pls_golite062009
  • nucleotidyltransferase activity
    		•  6.09236222725443 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  4.19036343419087 bayes_pls_golite062009
  • transferase activity
    		•  3.77083773614719 bayes_pls_golite062009
  • DNA binding
    		•  3.30555293228271 bayes_pls_golite062009
  • binding
    		•  2.49804507522731 bayes_pls_golite062009
  • transcription regulator activity
    		•  2.13161823862861 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.98019543873486 bayes_pls_golite062009
  • structural constituent of ribosome
    		•  1.93610624899943 bayes_pls_golite062009
  • structural molecule activity
    		•  1.75354740531381 bayes_pls_golite062009
  • structure-specific DNA binding
    		•  1.50253120414939 bayes_pls_golite062009
  • single-stranded DNA binding
    		•  1.25554419417176 bayes_pls_golite062009
  • catalytic activity
    		•  0.968175338682309 bayes_pls_golite062009
  • transcription factor activity
    		•  0.952503054446553 bayes_pls_golite062009
  • ribonuclease activity
    		•  0.889515634362309 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  0.664409046490378 bayes_pls_golite062009
  • nuclease activity
    		•  0.344602655860014 bayes_pls_golite062009
  • protein binding
    		•  0.301924922589452 bayes_pls_golite062009
  • translation regulator activity
    		•  0.272395932340767 bayes_pls_golite062009
  • translation factor activity, nucleic acid binding
    		•  0.224702431869342 bayes_pls_golite062009
    2 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.98

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle