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View Structure Prediction Details

Protein: RPA43
Organism: Saccharomyces cerevisiae
Length: 326 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for RPA43.

Description E-value Query
Range
Subject
Range
RPA43 - RNA polymerase I subunit A43
RPA43_YEAST - DNA-directed RNA polymerase I subunit RPA43 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c)...
gi|151945417 - gi|151945417|gb|EDN63660.1| RNA polymerase A [Saccharomyces cerevisiae YJM789]
gi|207340856 - gi|207340856|gb|EDZ69078.1| YOR340Cp-like protein [Saccharomyces cerevisiae AWRI1631]
0.0 [1..326] [1..326]
gi|85084873 - gi|85084873|ref|XP_957391.1| hypothetical protein NCU07166 [Neurospora crassa OR74A]
gi|28950262, gi|... - gi|32413945|ref|XP_327452.1| hypothetical protein [Neurospora crassa], gi|28950262|emb|CAD71128.1| r...
2.0E-74 [43..255] [161..380]
RPA43_SCHPO - DNA-directed RNA polymerase I subunit rpa43 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) G...
rpa43 - DNA-directed RNA polymerase I complex subunit Rpa43
1.0E-49 [42..186] [10..142]
gi|26382694 - gi|26382694|dbj|BAC25502.1| unnamed protein product [Mus musculus]
3.0E-44 [33..160] [43..158]
gi|33989527 - gi|33989527|gb|AAH56557.1| Twistnb protein [Danio rerio]
2.0E-42 [33..161] [48..164]
CG13773-PA - This gene is referred to in FlyBase by the symbol Dmel\CG13773 (CG13773, FBgn0042092). It is a prote...
9.0E-42 [15..157] [7..135]
gi|27451610 - gi|27451610|gb|AAO15001.1| twist neighbor [Takifugu rubripes]
5.0E-35 [32..162] [58..159]

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Predicted Domain #1
Region A:
Residues: [1-183]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSQVKRANEN RETARFIKKH KKQVTNPIDE KNGTSNCIVR VPIALYVSLA PMYLENPLQG  60
   61 VMKQHLNPLV MKYNNKVGGV VLGYEGLKIL DADPLSKEDT SEKLIKITPD TPFGFTWCHV 120
  121 NLYVWQPQVG DVLEGYIFIQ SASHIGLLIH DAFNASIKKN NIPVDWTFVH NDVEEDADVI 180
  181 NTD

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted functions:

Term Confidence Notes
RNA polymerase activity 8.49996804151214 bayes_pls_golite062009
DNA-directed RNA polymerase activity 8.49996804151214 bayes_pls_golite062009
nucleotidyltransferase activity 6.09236222725443 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 4.19036343419087 bayes_pls_golite062009
transferase activity 3.77083773614719 bayes_pls_golite062009
DNA binding 3.30555293228271 bayes_pls_golite062009
binding 2.49804507522731 bayes_pls_golite062009
transcription regulator activity 2.13161823862861 bayes_pls_golite062009
nucleic acid binding 1.98019543873486 bayes_pls_golite062009
structural constituent of ribosome 1.93610624899943 bayes_pls_golite062009
structural molecule activity 1.75354740531381 bayes_pls_golite062009
structure-specific DNA binding 1.50253120414939 bayes_pls_golite062009
single-stranded DNA binding 1.25554419417176 bayes_pls_golite062009
catalytic activity 0.968175338682309 bayes_pls_golite062009
transcription factor activity 0.952503054446553 bayes_pls_golite062009
ribonuclease activity 0.889515634362309 bayes_pls_golite062009
sequence-specific DNA binding 0.664409046490378 bayes_pls_golite062009
nuclease activity 0.344602655860014 bayes_pls_golite062009
protein binding 0.301924922589452 bayes_pls_golite062009
translation regulator activity 0.272395932340767 bayes_pls_golite062009
translation factor activity, nucleic acid binding 0.224702431869342 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [184-326]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ENNGNNNNED NKDSNGGSNS LGKFSFGNRS LGHWVDSNGE PIDGKLRFTV RNVHTTGRVV  60
   61 SVDGTLISDA DEEGNGYNSS RSQAESLPIV SNKKIVFDDE VSIENKESHK ELDLPEVKED 120
  121 NGSEIVYEEN TSESNDGESS DSD

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle