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Interacting selectively and non-covalently with DNA containing secondary structure elements such as four-way junctions, bubbles, loops, Y-form DNA, or double-strand/single-strand junctions. Interacting selectively and non-covalently with G-quadruplex DNA structures, in which groups of four guanines adopt a flat, cyclic Hoogsteen hydrogen-bonding arrangement known as a guanine tetrad. The stacking of guanine tetrads results in G-quadruplex DNA structures. G-quadruplex DNA can form under physiological conditions from some G-rich sequences, such as those found in telomeres, immunoglobulin switch regions, gene promoters, fragile X repeats, and the dimerization domain in the human immunodeficiency virus (HIV) genome. Interacting selectively and non-covalently with a flap structure in DNA. A DNA flap structure is one in which a single-stranded length of DNA or RNA protrudes from a double-stranded DNA molecule. Interacting selectively and non-covalently with any nucleic acid. Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). Interacting selectively and non-covalently with DNA that is assembled into chromatin. Interacting selectively and non-covalently with DNA in the Z form, i.e. a left-handed helix in which the phosphate backbone zigzags. Interacting selectively and non-covalently with double-stranded DNA. Interacting selectively and non-covalently with single-stranded DNA. Interacting selectively and non-covalently with the ends of DNA that are exposed by the creation of double-strand breaks (DSBs). Interacting selectively and non-covalently with DNA in a random coil configuration. Interacting selectively and non-covalently with a DNA triple helix. The formation of triple helical DNA has been evoked in several cellular processes including transcription, replication, and recombination. Interacting selectively and non-covalently with DNA of a specific structure or configuration e.g. triplex DNA binding or bent DNA binding. Interacting selectively and non-covalently with DNA in a bent conformation.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: structure-specific DNA binding
Acc: GO:0043566
Aspect: Molecular Function
Desc: Interacting selectively and non-covalently with DNA of a specific structure or configuration e.g. triplex DNA binding or bent DNA binding.
Synonyms:
  • structure specific DNA binding
Proteins in PDR annotated with:
   This term: 10 [Search]
   Term or descendants: 618 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0043566 - structure-specific DNA binding (interactive image map)
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