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Protein Overview: CDC14

General Information:
Name(s) found: CDC14 / YFR028C [SGD]
Description(s) found:
Found 24 descriptions.
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  • Protein phosphatase required for mitotic exit; located in the nucleolus until liberated by the FEAR and Mitotic Exit Network in anaphase, enabling it to act on key substrates to effect a decrease in CDK/B-cyclin activity and mitotic exit [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 551 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDALink to PubMed article]
    RENT complex [IDALink to PubMed article]
    spindle pole body [IDALink to PubMed article]
    nucleolus [IDALink to PubMed article]
    Biological Process: regulation of exit from mitosis [IGILink to PubMed article][IPILink to PubMed article]
    protein amino acid dephosphorylation [IDALink to PubMed article]
    Molecular Function: phosphoprotein phosphatase activity [IDALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MRRSVYLDNT IEFLRGRVYL GAYDYTPEDT DELVFFTVED AIFYNSFHLD FGPMNIGHLY  60
   61 RFAVIFHEIL NDPENANKAV VFYSSASTRQ RANAACMLCC YMILVQAWTP HQVLQPLAQV 120
  121 DPPFMPFRDA GYSNADFEIT IQDVVYGVWR AKEKGLIDLH SFNLESYEKY EHVEFGDFNV 180
  181 LTPDFIAFAS PQEDHPKGYL ATKSSHLNQP FKSVLNFFAN NNVQLVVRLN SHLYNKKHFE 240
  241 DIGIQHLDLI FEDGTCPDLS IVKNFVGAAE TIIKRGGKIA VHCKAGLGRT GCLIGAHLIY 300
  301 TYGFTANECI GFLRFIRPGM VVGPQQHWLY LHQNDFREWK YTTRISLKPS EAIGGLYPLI 360
  361 SLEEYRLQKK KLKDDKRVAQ NNIEGELRDL TMTPPSNGHG ALSARNSSQP STANNGSNSF 420
  421 KSSAVPQTSP GQPRKGQNGS NTIEDINNNR NPTSHANRKV VIESNNSDDE SMQDTNGTSN 480
  481 HYPKVSRKKN DISSASSSRM EDNEPSATNI NNAADDTILR QLLPKNRRVT SGRRTTSAAG 540
  541 GIRKISGSIK K

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Krogan NJ, et al. (2006) BDP1 CDC14 COY1 FAR7 MAF1 RET1 RPA12 RPA135 RPA14 RPA190 RPA34 RPA43 RPA49 RPC10 RPC11 RPC17 RPC19 RPC25 RPC31 RPC34 RPC37 RPC40 RPC53 RPC82 RPO31 YDL144C YIR024C
    View Details Gavin AC, et al. (2002) ADH1 AMS1 ASC1 BGL2 CDC14 DHH1 FBA1 HSP42 MAF1 NET1 RET1 RPA12 RPA135 RPA190 RPA43 RPA49 RPB10 RPB5 RPB8 RPC11 RPC17 RPC19 RPC25 RPC31 RPC34 RPC37 RPC40 RPC53 RPC82 RPO26 RPO31 RSC8 SIR2 SIR4 SRO7 TDH3 YEF3
    View Details Ho Y, et al. (2002) ACO1 ADK1 ATP3 ATP5 ATP7 CCT6 CDC14 DPM1 EGD2 ERB1 FUR1 GLC7 GND1 GUS1 HAS1 HEF3 HMS1 HXT7 MCR1 MET6 MRT4 MUB1 NOC2 NOC3 NOG1 NSA1 NUG1 PRP43 SAH1 SCS2 SEC53 SNF4 SPB4 SPE3 SSQ1 SSZ1 TIF6 TPS1 TSA2 UBR2 VAS1 YTM1
    View Details Qiu et al. (2008) CDC14 CDC5 CSM1 INP53 NET1 RTS1 SGO1 TEM1 TPD3

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run RPA135 No Comments Schneider, DA, et al. (2006)
    View Run MLP2 #33 Asynchronous SPB prep Keck JM, et al. (2011)
    View Run MLP2 #20 Asynchronous Prep1-TiO2 Phosphopeptide enrichment, PartB Keck JM, et al. (2011)
    View Run MLP2 #25 Asynchronous Prep3-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #24 Asynchronous Prep3-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)
    View Run MLP2 #26 Asynchronous Prep4-TiO2 Phosphopeptide enriched, Steps1-2 Keck JM, et al. (2011)
    View Run MLP2 #27 Asynchronous Prep4-TiO2 Phosphopeptide enriched, Steps3-5 Keck JM, et al. (2011)
    View Run MLP2 #22 Asynchronous Prep2-IMAC Phosphopeptide enrichment B1-2 Keck JM, et al. (2011)
    View Run MLP2 #34 Asynchronous SPB prep Keck JM, et al. (2011)
    View Run MLP2 #32 Asynchronous Prep-No Phosphopeptide enrichment Keck JM, et al. (2011)
    View Run MLP2 #35 Asynchronous SPB prep Keck JM, et al. (2011)
    View Run MLP2 #29 Asynchronous Prep5-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #14 Mitotic Prep2-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #13 Mitotic Prep2-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)
    View Run MLP2 #12 Mitotic Prep1-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #10 Mitotic Prep1-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)
    View Run MLP2 #30 Asynchronous Prep6-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)
    View Run MLP2 #11 Mitotic Prep1-TiO2 enriched, new search criteria Keck JM, et al. (2011)
    View Run MLP2 #06 Alpha Factor Prep3-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)
    View Run MLP2 #16 Mitotic-New search criteria Keck JM, et al. (2011)
    View Run MLP2 #15 Mitotic 2nd-TiO2 enriched, new search criteria Keck JM, et al. (2011)
    View Run None Entered #17 Mitotic Prep3-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)
    View Run None Entered #18 Mitotic Prep4-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data CDC14 and NOP56 Huh WK, et al. (2003)
    View Data CDC14 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..85] MSA 1.024986 View MSA. No confident structure predictions are available.
    2 View Details [86..477] PSI-BLAST 85.69897 RPTP Lar
    3 View Details [478..551] deduced N/A No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • phosphoprotein phosphatase activity
    		•  7.30669036331612 bayes_pls_golite062009
  • phosphatase activity
    		•  6.6585143972081 bayes_pls_golite062009
  • phosphoric ester hydrolase activity
    		•  6.44546424348532 bayes_pls_golite062009
  • hydrolase activity, acting on ester bonds
    		•  5.70473199778334 bayes_pls_golite062009
  • protein tyrosine phosphatase activity
    		•  5.3097342170423 bayes_pls_golite062009
  • alpha-actinin binding
    		•  3.03868073080583 bayes_pls_golite062009
  • actin binding
    		•  2.96334024905854 bayes_pls_golite062009
  • transmembrane receptor protein phosphatase activity
    		•  2.94635032478625 bayes_pls_golite062009
  • transmembrane receptor protein tyrosine phosphatase activity
    		•  2.94635032478625 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  2.93073637718155 bayes_pls_golite062009
  • protein tyrosine/serine/threonine phosphatase activity
    		•  2.77531895423367 bayes_pls_golite062009
  • protein serine/threonine phosphatase activity
    		•  2.49496709551693 bayes_pls_golite062009
  • protein binding
    		•  2.12487185456363 bayes_pls_golite062009
  • binding
    		•  2.06015698112379 bayes_pls_golite062009
  • hydrolase activity
    		•  1.9069800114411 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.24416639415232 bayes_pls_golite062009
  • DNA binding
    		•  1.19665037078743 bayes_pls_golite062009
  • inositol or phosphatidylinositol phosphatase activity
    		•  1.1200449509328 bayes_pls_golite062009
  • catalytic activity
    		•  1.06283028154109 bayes_pls_golite062009
  • lipid phosphatase activity
    		•  1.05085928819585 bayes_pls_golite062009
  • phosphoprotein phosphatase inhibitor activity
    		•  0.979874859714334 bayes_pls_golite062009
  • non-membrane spanning protein tyrosine phosphatase activity
    		•  0.724257798127697 bayes_pls_golite062009
  • transporter activity
    		•  0.653544405131346 bayes_pls_golite062009
  • phosphatase inhibitor activity
    		•  0.64132831041331 bayes_pls_golite062009
  • protein kinase activity
    		•  0.569334963316149 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  0.401311298433519 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  0.386515379888428 bayes_pls_golite062009
  • kinase activity
    		•  0.380629891538418 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  0.343848090522899 bayes_pls_golite062009
  • transmembrane receptor activity
    		•  0.291525352733402 bayes_pls_golite062009
  • receptor activity
    		•  0.191946218805025 bayes_pls_golite062009
  • enzyme binding
    		•  0.150910330021054 bayes_pls_golite062009
  • kinase binding
    		•  0.141802531311128 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  0.09373220143933 bayes_pls_golite062009
  • protein kinase binding
    		•  0.062562314598915 bayes_pls_golite062009
    2 No functions predicted.
    3 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.69

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle