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Protein Overview: SIR4

General Information:
Name(s) found: SIR4 / YDR227W [SGD]
Description(s) found:
Found 28 descriptions.
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  • Silent information regulator that, together with SIR2 and SIR3, is involved in assembly of silent chromatin domains at telomeres and the silent mating-type loci; potentially phosphorylated by Cdc28p; some alleles of SIR4 prolong lifespan [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 1358 amino acids

    Gene Ontology:
    Cellular Component: nuclear telomeric heterochromatin [IDALink to PubMed article]
    chromatin silencing complex [IDALink to PubMed article]
    nuclear telomere cap complex [IDALink to PubMed article]
    Biological Process: loss of chromatin silencing involved in replicative cell aging [IDALink to PubMed article]
    telomere maintenance [IMPLink to PubMed article]
    chromatin silencing [TASLink to PubMed article]
    double-strand break repair via nonhomologous end joining [IDALink to PubMed article]
    Molecular Function: structural constituent of chromatin [TASLink to PubMed article]
    histone binding [TASLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPNDNKTPNR SSTPKFTKKP VTPNDKIPER EEKSNEVKTP KIPLFTFAKS KNYSRPSTAI  60
   61 HTSPHQPSDV KPTSHKQLQQ PKSSPLKKNN YNSFPHSNLE KISNSKLLSL LRSKTSAGRI 120
  121 ESNNPSHDAS RSLASFEQTA FSRHAQQQTS TFNSKPVRTI VPISTSQTNN SFLSGVKSLL 180
  181 SEEKIRDYSK EILGINLANE QPVLEKPLKK GSADIGASVI SLTKDKSIRK DTVEEKKEEK 240
  241 LNIGKNFAHS DSLSVPKVSA GDSGISPEES KARSPGIAKP NAIQTEVYGI NEESTNERLE 300
  301 INQEKPVKLD ENSANSTVAS ALDTNGTSAT TETLTSKKIV PSPKKVAIDQ DKITLHDEKT 360
  361 LAPSKHQPIT SEQKMKEDAD LKRMEILKSP HLSKSPADRP QGRRNSRNFS TRDEETTKLA 420
  421 FLVEYEGQEN NYNSTSRSTE KKNDMNTSAK NKNGENKKIG KRPPEIMSTE AHVNKVTEET 480
  481 TKQIQSVRID GRKVLQKVQG ESHIDSRNNT LNVTPSKRPQ LGEIPNPMKK HKPNEGRTPN 540
  541 ISNGTINIQK KLEPKEIVRD ILHTKESSNE AKKTIQNPLN KSQNTALPST HKVTQKKDIK 600
  601 IGTNDLFQVE SAPKISSEID RENVKSKDEP VSKAVESKSL LNLFSNVLKA PFIKSESKPF 660
  661 SSDALSKEKA NFLETIASTE KPENKTDKVS LSQPVSASKH EYSDNFPVSL SQPSKKSFAN 720
  721 HTEDEQIEKK KICRGRMNTI ITHPGKMELV YVSDSDDSSS DNDSLTDLES LSSGESNEIK 780
  781 VTNDLDTSAE KDQIQAGKWF DPVLDWRKSD RELTKNILWR IADKTTYDKE TITDLIEQGI 840
  841 PKHSYLSGNP LTSVTNDICS VENYETSSAF FYQQVHKKDR LQYLPLYAVS TFENTNNTEK 900
  901 NDVTNKNINI GKHSQEQNSS SAKPSQIPTV SSPLGFEETK LSTTPTKSNR RVSHSDTNSS 960
  961 KPKNTKENLS KSSWRQEWLA NLKLISVSLV DEFPSELSDS DRQIINEKMQ LLKDIFANNL1020
 1021 KSAISNNFRE SDIIILKGEI EDYPMSSEIK IYYNELQNKP DAKKARFWSF MKTQRFVSNM1080
 1081 GFDIQKSCEP VSISTSVKPH VVEPEHMADA KIMPKDILQI TKKPLMVKNV KPSSPPDVKS1140
 1141 LVQLSTMETK TLPEKKQFDS IFNSNKAKII PGNGKHASEN ISLSFSRPAS YGYFSVGKRV1200
 1201 PIVEDRRVKQ LDDITDSNTT EILTSVDVLG THSQTGTQQS NMYTSTQKTE LEIDNKDSVT1260
 1261 ECSKDMKEDG LSFVDIVLSK AASALDEKEK QLAVANEIIR SLSDEVMRNE IRITSLQGDL1320
 1321 TFTKKCLENA RSQISEKDAK INKLMEKDFQ VNKEIKPY

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) GDH2 NET1 SIR2 SIR4
    View Details Krogan NJ, et al. (2006) GPG1 SIR2 SIR3 SIR4 YLR278C
    View Details Gavin AC, et al. (2002) ADH1 BGL2 CDC14 HSP42 NET1 SIR2 SIR4 TDH3 YEF3
    View Details Ho Y, et al. (2002) BLM10 SEC53 SIR2 SIR3 SIR4 SRP1 YFL006W
    View Details Qiu et al. (2008) FPR4 NET1 PCC1 RAP1 RIF1 SIR3 SIR4 SUB2 TBF1

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run ASF1 3829 - low filter Green EM, et al (2005)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data SIR4 Huh WK, et al. (2003)
    View Data SIR4 and NIC96 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..123] MSA 1.002954 View MSA. No confident structure predictions are available.
    2 View Details [124..1358] deduced N/A No confident structure predictions are available.
    3 View Details [277..390] deduced N/A No confident structure predictions are available.
    4 View Details [391..444] deduced N/A No confident structure predictions are available.
    5 View Details [445..659] deduced N/A No confident structure predictions are available.
    6 View Details [660..784] deduced N/A No confident structure predictions are available.
    7 View Details [785..924] deduced N/A No confident structure predictions are available.
    8 View Details [925..1081] deduced N/A No confident structure predictions are available.
    9 View Details [1082..1201] deduced N/A No confident structure predictions are available.
    10 View Details [1202..1358] PSI-BLAST 78.69897 Dimerization motif of sir4


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle