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Protein Overview: YLR278C

General Information:
Name(s) found: YLR278C [SGD]
Description(s) found:
Found 25 descriptions.
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  • Zinc-cluster protein; GFP-fusion protein localizes to the nucleus; mutant shows moderate growth defect on caffeine; has a prion-domain like fragment that increases frequency of [URE3]; YLR278C is not an essential gene [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 1341 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDALink to PubMed article]
    Biological Process: biological_process [ND]
    Molecular Function: molecular_function [ND]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGRPRKNVSQ EKIQQLKREL ELAGNRTDVL LQDKKGRSRS CLLCRRRKQR CDHKLPSCTA  60
   61 CLKAGIKCVQ PSKYSSSTSN SNTNNNTPTA GTVPPTPHPV IKRELQDSSI GAGAGAATSL 120
  121 NDMTIIKPIS TSNSNVDAGD ANEFRKTIKS VTTNSNPNLM RQDKDQYTIF LEKKLKSLET 180
  181 LLDLSPGCNQ YNYELSQYKK VSHLFSNNTS DYSRPNSSNM VILPLPSPSN KPLENTNNNG 240
  241 SNVNAATNDT SASTNNINNN NAICQSASLL NDPLETLDFT KCIFAKYNLK KEFLMYDPIF 300
  301 ELNEKLSRSF LDTFFTRLQF KYPILDEQEI YTFYDHYLHN KILIPPSSPA TSSAAPPSNS 360
  361 HSYSEIEFHF LSGRMWLVFS ISAYLLMTTG KYKGFPPHRY FSTAIRHITK CGLHLNYVQQ 420
  421 IELLTLLVLY IIRTDRDSLI LYDIIKDVMG ISKKKLHLNQ WYPNDPFANK KLRLFWCVYL 480
  481 LERMICVAVG KPYTIKESEI NLPLFNNDSF YTKGVHAAAP STNDHGVQFI NQSLKLRRIE 540
  541 SQFVETLQLL KNDSRSVKQS IDQLPLVRKF FEDLEVWRKS YSTLDVKNFE NETLKLYYYR 600
  601 SVRLLIQPYL EFFAPEDRLF RECQAAAGQI CQLYKIFHQK TLNGHSTPAV HTVFVAGVTL 660
  661 IYCMWLARNF DDQRRKKLGD ASKHTRPLIS ASLFSTMDDL RACSVCLYVM TERSNFARTF 720
  721 RDTFDQLMNA TVGNLIERCG PDSSELIFMA SSVAKRTEPK NINDEANKAI SSGDTLHDSN 780
  781 SANAANLSNS NDKNISHNGG MPPAVARIFG KGQAEEHAGF VENSQVDLAE QEKFKKKQGV 840
  841 LEKTSVPKSL AHLLTKMDDR SRISNSSMSY TTSSSSSSSS SSSSSTLSFP SSQEKNLKIN 900
  901 VNNDNNGMTI SSVNREHNNN HNNNNDNNNN NNNNNNNSNN NNNVNNNDNE SNSRSTTNNS 960
  961 CNNGNNSQYV RNNNVTMEND VERPIQDQYI VKKPTNQTEF DWQVFQQQAF LQQQLAQHNL1020
 1021 QAYLSSLNTD TMTNRSPSKS SSISTASSHS DPIPIAMTQS PTPYPQTSNM LPQQHVSRPL1080
 1081 PQQQREQPQQ HITSPQRFSE SNFTNQLNNG MINSNPLQSA IFSNHTSENK QLRDVEESNF1140
 1141 STSPLRADYG NNIISSIPAS FTSNSIPVSV KQARNGSSSG DILFSNGAHD MINNISTWTN1200
 1201 NSVLDALNSK SILQTIFPQS QEPSSLSMDK QQQQHQQQNM CSENNVTANN FQQTQNDPSY1260
 1261 NRNLFMMSNQ EGVQYNLDET EKNGPKTQVE ANTSANLHFD NVIPTVTNAD IRKKRSNWDN1320
 1321 MMTSGPVEDF WTINDDYGFL T

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Krogan NJ, et al. (2006) GPG1 SIR2 SIR3 SIR4 YLR278C

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run ASF1 3829 - low filter Green EM, et al (2005)
    View Run RPA135 No Comments Schneider, DA, et al. (2006)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data YLR278C Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..185] PSI-BLAST 14.522879 PPR1
    2 View Details [186..264] deduced N/A No confident structure predictions are available.
    3 View Details [265..681] MSA 4.08199 View MSA. No confident structure predictions are available.
    4 View Details [682..1341] MSA 15.144996 View MSA. No confident structure predictions are available.
    5 View Details [505..732] deduced N/A No confident structure predictions are available.
    6 View Details [733..1052] FFAS03 3.26 30S subunit
    7 View Details [1053..1249] PSI-BLAST 16.0 Crystal Structure Analysis of S.epidermidis adhesin SdrG binding to Fibrinogen (adhesin-ligand complex)
    8 View Details [1250..1341] deduced N/A No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • binding
    		•  0.226078362275538 bayes_pls_golite062009
    2
    Term Confidence Notes
  • binding
    		•  0.134879671454648 bayes_pls_golite062009
    3 No functions predicted.
    4 No functions predicted.
    5 No functions predicted.
    6 No functions predicted.
    7 No functions predicted.
    8 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.64

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle