YRC Logo
PROTEIN SEARCH:
Descriptions Names[Advanced Search]

View Structure Prediction Details

Protein: SIR4
Organism: Saccharomyces cerevisiae
Length: 1358 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



[What does the above image mean?]


[Show Ginzu Version Information]


Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for SIR4.

Description E-value Query
Range
Subject
Range
gi|190404822 - gi|190404822|gb|EDV08089.1| regulatory protein SIR4 [Saccharomyces cerevisiae RM11-1a]
SIR4 - Silent information regulator that, together with SIR2 and SIR3, is involved in assembly of silent ch...
SIR4_YEAST - Regulatory protein SIR4 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=SIR4 PE=1 SV=1
0.0 [1..1358] [1..1358]

Back

Predicted Domain #1
Region A:
Residues: [1-123]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPNDNKTPNR SSTPKFTKKP VTPNDKIPER EEKSNEVKTP KIPLFTFAKS KNYSRPSTAI  60
   61 HTSPHQPSDV KPTSHKQLQQ PKSSPLKKNN YNSFPHSNLE KISNSKLLSL LRSKTSAGRI 120
  121 ESN

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [124-1358]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NPSHDASRSL ASFEQTAFSR HAQQQTSTFN SKPVRTIVPI STSQTNNSFL SGVKSLLSEE  60
   61 KIRDYSKEIL GINLANEQPV LEKPLKKGSA DIGASVISLT KDKSIRKDTV EEKKEEKLNI 120
  121 GKNFAHSDSL SVPKVSAGDS GISPEESKAR SPGIAKPNAI QTEVYGINEE STNERLEINQ 180
  181 EKPVKLDENS ANSTVASALD TNGTSATTET LTSKKIVPSP KKVAIDQDKI TLHDEKTLAP 240
  241 SKHQPITSEQ KMKEDADLKR MEILKSPHLS KSPADRPQGR RNSRNFSTRD EETTKLAFLV 300
  301 EYEGQENNYN STSRSTEKKN DMNTSAKNKN GENKKIGKRP PEIMSTEAHV NKVTEETTKQ 360
  361 IQSVRIDGRK VLQKVQGESH IDSRNNTLNV TPSKRPQLGE IPNPMKKHKP NEGRTPNISN 420
  421 GTINIQKKLE PKEIVRDILH TKESSNEAKK TIQNPLNKSQ NTALPSTHKV TQKKDIKIGT 480
  481 NDLFQVESAP KISSEIDREN VKSKDEPVSK AVESKSLLNL FSNVLKAPFI KSESKPFSSD 540
  541 ALSKEKANFL ETIASTEKPE NKTDKVSLSQ PVSASKHEYS DNFPVSLSQP SKKSFANHTE 600
  601 DEQIEKKKIC RGRMNTIITH PGKMELVYVS DSDDSSSDND SLTDLESLSS GESNEIKVTN 660
  661 DLDTSAEKDQ IQAGKWFDPV LDWRKSDREL TKNILWRIAD KTTYDKETIT DLIEQGIPKH 720
  721 SYLSGNPLTS VTNDICSVEN YETSSAFFYQ QVHKKDRLQY LPLYAVSTFE NTNNTEKNDV 780
  781 TNKNINIGKH SQEQNSSSAK PSQIPTVSSP LGFEETKLST TPTKSNRRVS HSDTNSSKPK 840
  841 NTKENLSKSS WRQEWLANLK LISVSLVDEF PSELSDSDRQ IINEKMQLLK DIFANNLKSA 900
  901 ISNNFRESDI IILKGEIEDY PMSSEIKIYY NELQNKPDAK KARFWSFMKT QRFVSNMGFD 960
  961 IQKSCEPVSI STSVKPHVVE PEHMADAKIM PKDILQITKK PLMVKNVKPS SPPDVKSLVQ1020
 1021 LSTMETKTLP EKKQFDSIFN SNKAKIIPGN GKHASENISL SFSRPASYGY FSVGKRVPIV1080
 1081 EDRRVKQLDD ITDSNTTEIL TSVDVLGTHS QTGTQQSNMY TSTQKTELEI DNKDSVTECS1140
 1141 KDMKEDGLSF VDIVLSKAAS ALDEKEKQLA VANEIIRSLS DEVMRNEIRI TSLQGDLTFT1200
 1201 KKCLENARSQ ISEKDAKINK LMEKDFQVNK EIKPY

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [277-390]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 IAKPNAIQTE VYGINEESTN ERLEINQEKP VKLDENSANS TVASALDTNG TSATTETLTS  60
   61 KKIVPSPKKV AIDQDKITLH DEKTLAPSKH QPITSEQKMK EDADLKRMEI LKSP

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #4
Region A:
Residues: [391-444]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 HLSKSPADRP QGRRNSRNFS TRDEETTKLA FLVEYEGQEN NYNSTSRSTE KKND

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #5
Region A:
Residues: [445-659]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNTSAKNKNG ENKKIGKRPP EIMSTEAHVN KVTEETTKQI QSVRIDGRKV LQKVQGESHI  60
   61 DSRNNTLNVT PSKRPQLGEI PNPMKKHKPN EGRTPNISNG TINIQKKLEP KEIVRDILHT 120
  121 KESSNEAKKT IQNPLNKSQN TALPSTHKVT QKKDIKIGTN DLFQVESAPK ISSEIDRENV 180
  181 KSKDEPVSKA VESKSLLNLF SNVLKAPFIK SESKP

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #6
Region A:
Residues: [660-784]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 FSSDALSKEK ANFLETIAST EKPENKTDKV SLSQPVSASK HEYSDNFPVS LSQPSKKSFA  60
   61 NHTEDEQIEK KKICRGRMNT IITHPGKMEL VYVSDSDDSS SDNDSLTDLE SLSSGESNEI 120
  121 KVTND

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #7
Region A:
Residues: [785-924]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LDTSAEKDQI QAGKWFDPVL DWRKSDRELT KNILWRIADK TTYDKETITD LIEQGIPKHS  60
   61 YLSGNPLTSV TNDICSVENY ETSSAFFYQQ VHKKDRLQYL PLYAVSTFEN TNNTEKNDVT 120
  121 NKNINIGKHS QEQNSSSAKP 

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #8
Region A:
Residues: [925-1081]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SQIPTVSSPL GFEETKLSTT PTKSNRRVSH SDTNSSKPKN TKENLSKSSW RQEWLANLKL  60
   61 ISVSLVDEFP SELSDSDRQI INEKMQLLKD IFANNLKSAI SNNFRESDII ILKGEIEDYP 120
  121 MSSEIKIYYN ELQNKPDAKK ARFWSFMKTQ RFVSNMG

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #9
Region A:
Residues: [1082-1201]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 FDIQKSCEPV SISTSVKPHV VEPEHMADAK IMPKDILQIT KKPLMVKNVK PSSPPDVKSL  60
   61 VQLSTMETKT LPEKKQFDSI FNSNKAKIIP GNGKHASENI SLSFSRPASY GYFSVGKRVP 120
  121 

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #10
Region A:
Residues: [1202-1358]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 IVEDRRVKQL DDITDSNTTE ILTSVDVLGT HSQTGTQQSN MYTSTQKTEL EIDNKDSVTE  60
   61 CSKDMKEDGL SFVDIVLSKA ASALDEKEKQ LAVANEIIRS LSDEVMRNEI RITSLQGDLT 120
  121 FTKKCLENAR SQISEKDAKI NKLMEKDFQV NKEIKPY

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 78.69897
Match: 1nyhA
Description: Dimerization motif of sir4
Matching Structure (courtesy of the PDB):

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle