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The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. A DNA repair process in which that does not require the exchange of genetic material between the broken DNA molecule and a homologous region of DNA. The repair of a double-strand break in DNA in which the two broken ends are rejoined with little or no sequence complementarity. Information at the DNA ends may be lost due to the modification of broken DNA ends. The repair of double-strand breaks in DNA via homologous and nonhomologous mechanisms to reform a continuous DNA helix.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: double-strand break repair via nonhomologous end joining
Acc: GO:0006303
Aspect: Biological Process
Desc: The repair of a double-strand break in DNA in which the two broken ends are rejoined with little or no sequence complementarity. Information at the DNA ends may be lost due to the modification of broken DNA ends.
Synonyms:
  • NHEJ
Proteins in PDR annotated with:
   This term: 84 [Search]
   Term or descendants: 84 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0006303 - double-strand break repair via nonhomologous end joining (interactive image map)
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle