YRC Logo
PROTEIN SEARCH:
Descriptions Names[Advanced Search]

Protein Overview: SSQ1

General Information:
Name(s) found: SSQ1 / YLR369W [SGD]
Description(s) found:
Found 22 descriptions.
SHOW ALL
  • Mitochondrial hsp70-type molecular chaperone, required for assembly of iron/sulfur clusters into proteins at a step after cluster synthesis, and for maturation of Yfh1p, which is a homolog of human frataxin implicated in Friedreich's ataxia [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 657 amino acids

    Gene Ontology:
    Cellular Component: mitochondrial matrix [IDALink to PubMed article]
    mitochondrion [IDALink to PubMed article]
    Biological Process: DNA-dependent DNA replication [IMPLink to PubMed article]
    intracellular sequestering of iron ion [IMPLink to PubMed article]
    Molecular Function: unfolded protein binding [ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLKSGRLNFL KLNINSRLLY STNPQLTKKV IGIDLGTTNS AVAYIRDSND KKSATIIEND  60
   61 EGQRTTPSIV AFDVKSSPQN KDQMKTLVGM AAKRQNAINS ENTFFATKRL IGRAFNDKEV 120
  121 QRDMAVMPYK IVKCESNGQA YLSTSNGLIQ SPSQIASILL KYLKQTSEEY LGEKVNLAVI 180
  181 TVPAYFNDSQ RQATKDAGKL AGLNVLRVIN EPTAAALSFG IDDKRNNGLI AVYDLGGGTF 240
  241 DISILDIEDG VFEVRATNGD THLGGEDFDN VIVNYIIDTF IHENPEITRE EITKNRETMQ 300
  301 RLKDVSERAK IDLSHVKKTF IELPFVYKSK HLRVPMTEEE LDNMTLSLIN RTIPPVKQAL 360
  361 KDADIEPEDI DEVILVGGMT RMPKIRSVVK DLFGKSPNSS VNPDETVALG AAIQGGILSG 420
  421 EIKNVLLLDV TPLTLGIETF GGAFSPLIPR NTTVPVKKTE IFSTGVDGQA GVDIKVFQGE 480
  481 RGLVRNNKLI GDLKLTGITP LPKGIPQIYV TFDIDADGII NVSAAEKSSG KQQSITVIPN 540
  541 SGLSEEEIAK LIEEANANRA QDNLIRQRLE LISKADIMIS DTENLFKRYE KLISSEKEYS 600
  601 NIVEDIKALR QAIKNFKANE NDMSIDVNGI KKATDALQGR ALKLFQSATK NQQNQGK

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Krogan NJ, et al. (2006) BUD22 CIC1 DBP6 EFG1 FRE3 GIS2 HAS1 MAK21 NIP7 NOB1 NOC2 NOC3 NOP1 NOP2 NOP8 PUS7 RRP5 RSA3 SBP1 SFA1 SSQ1 YGR272C YMR034C YRF1-8, YRF1-5, ...
    View Details Ho Y, et al. (2002) ACO1 CCT6 CDC14 EGD2 ERB1 GND1 GUS1 HAS1 HXT7 MET6 MRT4 MUB1 NOC2 NOC3 NOG1 NSA1 NUG1 PRP43 SAH1 SCS2 SEC53 SPB4 SSQ1 TIF6 UBR2 YTM1

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run RPA135 No Comments Schneider, DA, et al. (2006)
    View Run BOI1 Sample boi 1 with ha tag from october 2005 McCusker D, et al (2007)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data SSQ1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..210]
    [405..420]    		 PSI-BLAST 1885.228787 Heat shock protein 70kDa, ATPase fragment
    2 View Details [211..266]
    [346..404]    		 PSI-BLAST 1885.228787 Heat shock protein 70kDa, ATPase fragment
    3 View Details [267..345] PSI-BLAST 1885.228787 Heat shock protein 70kDa, ATPase fragment
    4 View Details [421..657] PSI-BLAST 479.383689 DnaK

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • unfolded protein binding
    		•  4.93074236328581 bayes_pls_golite062009
  • structural molecule activity
    		•  3.59589495899762 bayes_pls_golite062009
  • structural constituent of cytoskeleton
    		•  2.46121037473545 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  2.20983242331685 bayes_pls_golite062009
  • binding
    		•  2.11855816699924 bayes_pls_golite062009
  • protein binding
    		•  2.00711904074672 bayes_pls_golite062009
  • carbohydrate kinase activity
    		•  1.95648644394423 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.68670098354938 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.43834016708999 bayes_pls_golite062009
  • peptidase activity
    		•  1.4127499531612 bayes_pls_golite062009
  • DNA binding
    		•  1.36804228074586 bayes_pls_golite062009
  • transporter activity
    		•  1.2883466875237 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  1.16749728168925 bayes_pls_golite062009
  • kinase activity
    		•  1.11102445353265 bayes_pls_golite062009
  • actin binding
    		•  1.03829083423378 bayes_pls_golite062009
  • hexokinase activity
    		•  1.02961928132432 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  0.953663805249074 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides
    		•  0.900931843471417 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
    		•  0.898645342556399 bayes_pls_golite062009
  • pyrophosphatase activity
    		•  0.875671218597808 bayes_pls_golite062009
  • hydrolase activity
    		•  0.807017237368431 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  0.796517590178929 bayes_pls_golite062009
  • transcription factor activity
    		•  0.783439770973386 bayes_pls_golite062009
  • nucleoside-triphosphatase activity
    		•  0.78242344952806 bayes_pls_golite062009
  • protein transporter activity
    		•  0.780308299678282 bayes_pls_golite062009
  • ATPase activity
    		•  0.687771333492666 bayes_pls_golite062009
  • myosin binding
    		•  0.607451856096 bayes_pls_golite062009
  • glucose binding
    		•  0.54517877621659 bayes_pls_golite062009
  • catalytic activity
    		•  0.296484721581333 bayes_pls_golite062009
  • general RNA polymerase II transcription factor activity
    		•  0.186218331473028 bayes_pls_golite062009
  • sugar binding
    		•  0.13092093336273 bayes_pls_golite062009
  • protease binding
    		•  0.121259015422625 bayes_pls_golite062009
  • chaperone binding
    		•  0.00111313452804307 bayes_pls_golite062009
    2 No functions predicted.
    3 No functions predicted.
    4 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle