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Protein Overview: UBR2

General Information:
Name(s) found: UBR2 / YLR024C [SGD]
Description(s) found:
Found 25 descriptions.
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  • Cytoplasmic ubiquitin-protein ligase (E3); required for ubiquitylation of Rpn4p; mediates formation of a Mub1p-Ubr2p-Rad6p complex [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 1872 amino acids

    Gene Ontology:
    Cellular Component: cytoplasm [IDALink to PubMed article]
    Biological Process: protein polyubiquitination [TASLink to PubMed article]
    protein monoubiquitination [TASLink to PubMed article]
    Molecular Function: ubiquitin-protein ligase activity [TASLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MEDSDLSITN IRDFLTELPK LAKCEYSETT SYLLWKTLNL RLKHSDNDIN WRSLVSILNS  60
   61 EAWENEKYRD ILNGRKWRTL EFENDHHSVG NMHIGTACTR LCFPSETIYY CFTCSTNPLY 120
  121 EICELCFDKE KHVNHSYVAK VVMRPEGRIC HCGDPFAFND PSDAFKCKNE LNNIPISNDN 180
  181 SNVTDDENVI SLLNYVLDFL IDVTVSYKEE AEAHSSERKA SSLMHPNQNS ITDDIMEKHE 240
  241 CEPLVNDENF VFFDNNWSNT RKEAHMEWAI QIEEEECNVH YMDLASTITR ILNTPVEYAI 300
  301 SITKALEDSH DVVTVLQSEN FFEIDQIAKE FQKENIVVHV RKADDIFKRK LTDDLTDWLY 360
  361 SLCFKAATSL QNKYALRISM LDVWYSHFSK MRVSPTNTNP DFSKINLLGG FLISNEDSDE 420
  421 SWFKPWSLEN IEDERISKIL TNYNERLIRA HSPNTVSHFY NFYGSRFQYI IINSINILSK 480
  481 KSKFKMLKIM ASLFSLRDES RKFLAAQYID VYLSVLYDAV ASDAKECQVT LMSILGQYTF 540
  541 QDPSIANMTI SSGFIERTIR FAFTLMAFNP EDLMSYLPIS LYNGFKLPTE TIRNRRTIIC 600
  601 FKDLCTIMSA NTVPEELLSN EAIFNAIIES FSEFSNVLPL KRETKEHVEV ENFDFSAFYF 660
  661 FFSSILIMTD GYTRSISLVK DAAFRKQIVL KLLDVAQTRE FESLTNSRKA ISPDNASTNE 720
  721 NDSNKATLST VRETICNYVA ETINFQVGVN TQYFFNPMSY LFKFVIQWSQ CGRYEPIPAS 780
  781 LTNYINLFEV FQDKQKALYI SESALSTLVL IGQINVGFWV RNGTPITHQA RMYTKYSMRE 840
  841 FTYISDIFNV QFSMAMCNPD ELMVTYLSRW GLKHWANGVP MYDYPDTETT VAVVNECILL 900
  901 LIQLLTEVRS LVMKSSKEGF ERTFKSEIIH ALCFDTCSYA QIVNCIPEHI TKHPSFDIYL 960
  961 EKYANYTSPV SLTDNGIFVL KEKYKDEIDP YYIGLSSSRR YDVEKNIRLN MANLKKMKYE1020
 1021 DTFVPAKKVK DLLKNTLFSG LYSISSVNTF GLFLKNTLDH IIKYDYDNLL PRVVHLIHLC1080
 1081 VVNNLNEFMG ILWHEYAIVD TEFCHYHSIG SILYYCLLKD NFSESHGKIR EIFRYLMETA1140
 1141 PHVNVNSYLR EQTTSYTPGI LWPTKEDKSH KDKEFERKKH LARLRKKKLM KKLAQQQMKF1200
 1201 MENNSVDTSD ISTPRTTSPS LSPTRINAEN SSNTINSCCD DDCVFCKMPK DDDVFVYFSY1260
 1261 QERNICDHGI DFTNPTDVNR INSLFSGKQT KDSAIQENPQ DDDGTRLKFT SCEPVLRACG1320
 1321 HGSHTKCLSG HMKSIRGIQN QTTKNIPLSY GSGLIYCPVC NSLSNSFLPK TNDIDKRTSS1380
 1381 QFFMCIEKRS EAEENLDPMS SICIKAAMIL GDLQGKKVTT IEDAYKVVNS VFINTISNTE1440
 1441 LRLRSHKKEG KIVNMERISS QCILTLHLVC ELKSFIYKKF VNSKTFSSEI SRKIWNWNEF1500
 1501 LIKGNNVNLL LYMSQNFDNI DGGKTPQPPN LCIYEMFKRR FHQLLLLLAR DMMRVNFYKD1560
 1561 CRNKIKISSN GSEEPSTSFS YLFNTFKKYV DLFKPDDVRF DFTSLEKIKD FICSLLLESL1620
 1621 SIFCRRTFLL FNIQYDDDGD GDNNNNRSNN FMDVKQREIE LIFRYFKLPN LTHFLKDFFY1680
 1681 NELTQNIERY NDGNDNLRIQ QVIYDMVQNI NTRAYPSPEH IQLIELPLNL SKFSLDNDEI1740
 1741 SNKCDKYEIA VCLLCGQKCH IQKSIALQGY LQGECTDHMR NGCEITSAYG VFLMTGTNAI1800
 1801 YLSYGKRGTF YAAPYLSKYG ETNEDYKFGT PVYLNRARYA NLANEIVFGN MIPHIVFRLT1860
 1861 DGSADLGGWE TM

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Krogan NJ, et al. (2006) DET1 UBR2
    View Details Ho Y, et al. (2002) ACO1 CCT6 CDC14 EGD2 ERB1 GND1 GUS1 HAS1 HXT7 MET6 MRT4 MUB1 NOC2 NOC3 NOG1 NSA1 NUG1 PRP43 SAH1 SCS2 SEC53 SPB4 SSQ1 TIF6 UBR2 YTM1

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run PAN1 No Comments Toshima J, et al (2006)
    View Run RPA135 No Comments Schneider, DA, et al. (2006)
    View Run ZDS1 Sample 2- cpn2 from june 2005 McCusker D, et al (2007)
    View Run MLP2 #35 Asynchronous SPB prep Keck JM, et al. (2011)
    View Run MLP2 #03 Alpha Factor Prep1-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #12 Mitotic Prep1-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #02 Alpha Factor Prep1-TiO2 enriched, new search criteria Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data UBR2 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..81] deduced N/A Confident ab initio structure predictions are available.
    2 View Details [82..173] Pfam 32.958607 Putative zinc finger in N-recognin No confident structure predictions are available.
    3 View Details [174..713] deduced N/A No confident structure predictions are available.
    4 View Details [714..1270] MSA 2.015884 View MSA. No confident structure predictions are available.
    5 View Details [1271..1570] deduced N/A No confident structure predictions are available.
    6 View Details [1571..1872] MSA 5.006938 View MSA. No confident structure predictions are available.
    7 View Details [1017..1169] deduced N/A No confident structure predictions are available.
    8 View Details [1170..1375] MSA 1.054979 View MSA. No confident structure predictions are available.
    9 View Details [1376..1576] deduced N/A No confident structure predictions are available.
    10 View Details [1577..1714] MSA 1.033991 View MSA. No confident structure predictions are available.
    11 View Details [1715..1872] MSA 3.038988 View MSA. No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3 No functions predicted.
    4 No functions predicted.
    5 No functions predicted.
    6
    Term Confidence Notes
  • nucleic acid binding
    		•  2.23450316335876 bayes_pls_golite062009
  • binding
    		•  2.14387047687719 bayes_pls_golite062009
  • DNA binding
    		•  2.04297552772596 bayes_pls_golite062009
  • transcription regulator activity
    		•  2.02735936435983 bayes_pls_golite062009
  • ubiquitin-protein ligase activity
    		•  1.32633588604151 bayes_pls_golite062009
  • transcription factor activity
    		•  1.26194702122873 bayes_pls_golite062009
  • small conjugating protein ligase activity
    		•  1.15892915621711 bayes_pls_golite062009
  • protein binding
    		•  0.863483803868456 bayes_pls_golite062009
  • acid-amino acid ligase activity
    		•  0.74103129816245 bayes_pls_golite062009
  • ligase activity, forming carbon-nitrogen bonds
    		•  0.201004090113231 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  0.111186019165274 bayes_pls_golite062009
    7 No functions predicted.
    8 No functions predicted.
    9 No functions predicted.
    10 No functions predicted.
    11 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.96

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle