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Protein Overview: PAN1

General Information:
Name(s) found: PAN1 / YIR006C [SGD]
Description(s) found:
Found 25 descriptions.
SHOW ALL
  • Part of actin cytoskeleton-regulatory complex Pan1p-Sla1p-End3p, associates with actin patches on the cell cortex; promotes protein-protein interactions essential for endocytosis; previously thought to be a subunit of poly(A) ribonuclease [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 1480 amino acids

    Gene Ontology:
    Cellular Component: plasma membrane [IDALink to PubMed article]
    actin cortical patch [IDALink to PubMed article]
    Biological Process: axial cellular bud site selection [IMPLink to PubMed article]
    bipolar cellular bud site selection [IMPLink to PubMed article]
    cytokinesis [IMPLink to PubMed article]
    endocytosis [IMPLink to PubMed article]
    actin cortical patch assembly [TASLink to PubMed article]
    Molecular Function: protein binding, bridging [IPILink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MYNPYQQQGM GYQQQQQQQQ QQPNGFYPQQ QQGQSSNQPQ GQPQPQQQMA FNQPQATGIG  60
   61 GMPQSFGNSF SSMPQQPQTG YNNNGNNGSV YGNGNFGQQP QQQQQQAKPQ HTGYVPNSSM 120
  121 PMMNTTGTMP PPNPAQQPQL QSIQPQGTGY YQAANTANVH SVQPLQSQGT GYYVSTPNLI 180
  181 SSNQTQQPLQ AQGTGYYQSQ PQQVPPPQQA QSLQPLKPQQ TGFYLQPQNQ APLEPLKPTA 240
  241 TGFVNSFANN GLNNDIKIPA IRLSFITAQD QAKFETLFRS IVTNGSNTVS GANCRKILMR 300
  301 SGLPPSQLAR IWTLCDTSKA GELLFPEFAL AMHLINDVLQ GDTIPYELDS KTKNEVSSFI 360
  361 DAINLSIANQ DSSANDAPKT PFDEFITAGV QNLQPQPTGY MPQTSFGIPL QSQITGGGVA 420
  421 SALNPQSTGF MAPTTFNMSM NTGTPGLNPQ ITGGAPASMQ PNITGNALQP QTTGMMPQTT 480
  481 GMMPQTTGMM PQTSFGVNLG PQLTGGALQS QYTGGYGSVM PQQSGPASMP NLSFNQQGLQ 540
  541 SQLTGLQPQP TGFLPPSNFS ATMPLTAQKT GFGNNEIYTK SNFNNNLIDN SSQDKISTEE 600
  601 KSLFYKIFET FDTQNKGLLD SPTAVEIFRK SGLNRADLEQ IWNLCDINNT GQLNKQEFAL 660
  661 GMHLVYGKLN GKPIPNVLPS SLIPSSTKLL DNLKNQLKTE PTTTKEKPSF GKIDALSYKN 720
  721 NDDDVLPNYR NRRKVYSAKN EEQSSFSSPS AKSVNHSSST LQTDDISVDK TVEKKTAKPK 780
  781 YAGFSREINL KNIASLENEI KNISNPENCY DSSIPSDLTS RFDAIIAKLP NLFNEISTID 840
  841 NEITNAKIQL YRKKNPSSII GSGPNGEITE NDRKKAKSRA LLRARMSALT GKSTESEDSL 900
  901 SMEDEQQSAE IKRIQQENGK NQEIIKDIRS SISDISASLK STMTGSNMIS NQEFERWEFG 960
  961 IGLEDGVREF LDDLKSNSNK SVTESSPFVP SSTPTPVDDR SSSPSYSQFK TAEERAAYLK1020
 1021 EQAKKRMKEK LAKFDKNRRN VTQSSRSISS ENSREQPQQI AGSSNLVEPR ATPFQEEKYV1080
 1081 EVAQPTQPVQ STQPVQPTQP VQPTQPVQPT QPVQPTQPVQ PTQPVQNVYN AKQESDDEDE1140
 1141 DDEEKRLQEE LKRLKLKKKA DKEKRLAALR KQIEDAQNES DEEETNGKDN FGGHVNVPQA1200
 1201 APVAPSAAFS QNSTNAPRSV HAAVTPAAGK NSTGLPSTTM GHNPYFKDAS ASSTSTFDAR1260
 1261 AAEMQRRIQR GLDEDEDDGW SDEDESNNRV AVDNKVEEAK IGHPDHARAP PVTAAPLPSV1320
 1321 TPVPPAVPVP QANTSNEKSS PIPIAPIPPS VTQEPPVPLA PPLPAVDGFQ EPPIPSAPAI1380
 1381 ATAVQKSGSS TPALAGGVLP PPPPLPTQQA STSEPIIAHV DNYNGAEKGT GAYGSDSDDD1440
 1441 VLSIPESVGT DEEEEGAQPV STAGIPSIPP AGIPPPPPLP

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details (MIPS) Mewes HW, et al. (2004) ABP1 AIP1 ARC40 ARP2 BEM1 BUD6 CAP1 CAP2 COF1 CRN1 DLD2 GLK1 LAS17 OYE2 PAN1 PFY1 RVS167 SAC6 SLA1 SLA2 SRV2 TPM1 TPM2 TWF1 VRP1
    View Details Krogan NJ, et al. (2006) END3 PAN1
    View Details Qiu et al. (2008) ABP1 ABP140 ACT1 AIP1 ARP2 BBC1 BNI1 BSP1 BUD4 BUD6 CAP2 COF1 CRN1 EDE1 END3 ENT1 ENT2 ENT3 ENT4 INP53 IQG1 LAS17 MYO3 MYO5 PAN1 PEA2 PFY1 RVS167 SAC6 SCD5 SCP1 SLA1 SLA2 SPA2 SRV2 TPM1 TWF1 VRP1 YAP1802

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run PAN1 No Comments Toshima J, et al (2006)
    View Run PAN1 No Comments Toshima J, et al (2006)
    View Run RPA135 his-HA tag on RPA135 Schneider, DA, et al. (2006)
    View Run RPA135 his-HA tag on RPA135 Schneider, DA, et al. (2006)
    View Run DAD1 Dam1-765 complex purified from yeast with Dad1-TAP Shimogawa MM, et al. (2006)
    View Run CEP3 sample cbf3 from feb 2005 Sandall S, et all (2006)
    View Run ZDS1 Sample 2- cpn2 from june 2005 McCusker D, et al (2007)
    View Run ZDS1 Sample 3 - cpn + atp, from june 2005 McCusker D, et al (2007)
    View Run MLP2 #24 Asynchronous Prep3-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)
    View Run MLP2 #29 Asynchronous Prep5-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #14 Mitotic Prep2-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #12 Mitotic Prep1-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #30 Asynchronous Prep6-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)
    View Run None Entered #17 Mitotic Prep3-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen GTS1 PAN1 2 Unpublished Fields Lab Data
    View Screen SNX4 PAN1 2 Unpublished Fields Lab Data
    View Screen PRP40 PAN1 2 Unpublished Fields Lab Data
    View Screen MVP1 PAN1 2 Unpublished Fields Lab Data
    View Screen COG4 PAN1 2 Unpublished Fields Lab Data
    View Screen GLC7 PAN1 2 Uetz P, et al. (2000)

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data PAN1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..235] ORFEUS 11.5 Fibrinogen
    2 View Details [236..354] PSI-BLAST 111.68867 Reps1
    3 View Details [355..592] ORFEUS 14.7 RBP1
    4 View Details [593..692] PSI-BLAST 115.9897 Eps15
    5 View Details [693..1018] ORFEUS 12.21 Hybrid domain of integrin beta; Integrin beta A domain; Integrin beta tail domain; Integrin beta EGF-like domains
    6 View Details [1019..1169] ORFEUS 12.21 Hybrid domain of integrin beta; Integrin beta A domain; Integrin beta tail domain; Integrin beta EGF-like domains
    7 View Details [1170..1181]
    [1408..1480]    		 ORFEUS 11.82 No description for 1l8mA was found.
    8 View Details [1182..1254] ORFEUS 11.82 No description for 1l8mA was found.
    9 View Details [1255..1334] ORFEUS 11.82 No description for 1l8mA was found.
    10 View Details [1335..1407] ORFEUS 11.82 No description for 1l8mA was found.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3 No functions predicted.
    4
    Term Confidence Notes
  • actin binding
    		•  3.96919556235483 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  3.49668552859347 bayes_pls_golite062009
  • structural constituent of muscle
    		•  3.12414907235012 bayes_pls_golite062009
  • binding
    		•  3.02768444846642 bayes_pls_golite062009
  • microfilament motor activity
    		•  2.9702957313812 bayes_pls_golite062009
  • motor activity
    		•  2.57627414053278 bayes_pls_golite062009
  • actin filament binding
    		•  2.35534489389161 bayes_pls_golite062009
  • myosin binding
    		•  2.34125070430971 bayes_pls_golite062009
  • actin-dependent ATPase activity
    		•  2.06646671333275 bayes_pls_golite062009
  • calcium ion binding
    		•  1.75413488311654 bayes_pls_golite062009
  • metal ion binding
    		•  1.19984728454368 bayes_pls_golite062009
  • cation binding
    		•  1.19984728454368 bayes_pls_golite062009
  • ion binding
    		•  1.1923653453763 bayes_pls_golite062009
  • protein binding
    		•  1.18539140568889 bayes_pls_golite062009
  • transporter activity
    		•  1.15928534291452 bayes_pls_golite062009
  • actin monomer binding
    		•  0.9954841049256 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  0.945691505472547 bayes_pls_golite062009
  • tubulin binding
    		•  0.710693016758742 bayes_pls_golite062009
  • myosin heavy chain binding
    		•  0.61866037435065 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  0.438908712437433 bayes_pls_golite062009
  • myosin II binding
    		•  0.311147527050891 bayes_pls_golite062009
  • microtubule binding
    		•  0.278596514315141 bayes_pls_golite062009
  • active transmembrane transporter activity
    		•  0.246383459363256 bayes_pls_golite062009
  • structural molecule activity
    		•  0.234626449126289 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  0.20908131617536 bayes_pls_golite062009
  • structural constituent of cytoskeleton
    		•  0.116648335890738 bayes_pls_golite062009
    5 No functions predicted.
    6 No functions predicted.
    7 No functions predicted.
    8 No functions predicted.
    9 No functions predicted.
    10 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle