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Protein Overview: ENT3

General Information:
Name(s) found: ENT3 / YJR125C [SGD]
Description(s) found:
Found 30 descriptions.
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  • Protein containing an N-terminal epsin-like domain involved in clathrin recruitment and traffic between the Golgi and endosomes; associates with the clathrin adaptor Gga2p [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 408 amino acids

    Gene Ontology:
    Cellular Component: clathrin vesicle coat [IDALink to PubMed article]
    actin cortical patch [IPILink to PubMed article]
    Biological Process: protein targeting [IMPLink to PubMed article]
    actin filament organization [ISSLink to PubMed article]
    endocytosis [ISSLink to PubMed article]
    actin cortical patch assembly [ISSLink to PubMed article]
    Golgi to endosome transport [IMPLink to PubMed article]
    Molecular Function: protein binding [IPILink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSLEDTLANM SLYDAKKYFR KAQNVVFNYT EMEGKVREAT NNEPWGASST LMDQISQGTY  60
   61 NFREREEILS MIFRRFTEKA GSEWRQIYKA LQLLDYLIKH GSERFIDDTR NSINLIRILE 120
  121 TFHYIDSQGR DQGINVRTRV KALIELLSDD NKIRAERKKA RETAKKYKGV AGGSASADGS 180
  181 LNSKAGFTST KVHGISVSAD FDSDNEDNED GSFSQNGYND NASRATSTPG QGKQEPEDFV 240
  241 DFFSSESSKP SKELIQEDEK KADEEEDDDD EFSEFQSAVP VTNPANSFNL LNTSPIEGMP 300
  301 ATTSSMPFYN SSTTDQGKIT PAIAEPKKVD PFSSLFSTAK ASAEAPSAPK ASQAKAAASN 360
  361 PVSNSTTALS TDQDDDDEFG EMHGGAVQQE QNTNNNHTSS KEIDLLSF

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) ENT3 RPL27B RPS1B
    View Details Krogan NJ, et al. (2006) CSL4 DDI1 DIS3 ENT3 LRP1 MPP6 MTR3 OSM1 RRP4 RRP40 RRP42 RRP43 RRP45 RRP46 RRP6 SKI6 SKI7 YBL055C
    View Details Qiu et al. (2008) ABP1 AIP1 BCH1 CAP2 COF1 EDE1 END3 ENT1 ENT3 ENT5 PAN1 PFY1 SLA1 SLA2 TWF1 VRP1

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..167] PSI-BLAST 387.491979 Epsin 1
    2 View Details [168..408] MSA 43.195997 View MSA. No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • clathrin binding
    		•  7.05477548709703 bayes_pls_golite062009
  • binding
    		•  2.34501465852339 bayes_pls_golite062009
  • protein binding
    		•  1.97365365208963 bayes_pls_golite062009
  • phospholipid binding
    		•  1.38798066582556 bayes_pls_golite062009
  • phosphoinositide binding
    		•  1.26458267960741 bayes_pls_golite062009
  • phosphatidylinositol-4,5-bisphosphate binding
    		•  1.20269437433936 bayes_pls_golite062009
  • lipid binding
    		•  0.176990783274449 bayes_pls_golite062009
  • GTPase binding
    		•  0.0887270623721197 bayes_pls_golite062009
  • small GTPase binding
    		•  0.0268749201897704 bayes_pls_golite062009
    2 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle