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Protein Overview: LRP1

General Information:
Name(s) found: LRP1 / YHR081W [SGD]
Description(s) found:
Found 32 descriptions.
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  • Nuclear exosome-associated nucleic acid binding protein; involved in RNA processing, surveillance, degradation, tethering, and export; homolog of mammalian nuclear matrix protein C1D involved in regulation of DNA repair and recombination [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 184 amino acids

    Gene Ontology:
    Cellular Component: nuclear exosome (RNase complex) [IPILink to PubMed article]
    Biological Process: DNA repair [IDALink to PubMed article]
    snRNA processing [IDALink to PubMed article]
    double-strand break repair via homologous recombination [IDALink to PubMed article]
    telomere maintenance [IMPLink to PubMed article]
    snoRNA processing [IDALink to PubMed article]
    double-strand break repair via nonhomologous end joining [IDALink to PubMed article]
    mRNA catabolic process [IDALink to PubMed article]
    processing of 27S pre-rRNA [IMPLink to PubMed article]
    Molecular Function: molecular_function [ND]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MEDIEKIKPY VRSFSKALDE LKPEIEKLTS KSLDEQLLLL SDERAKLELI NRYAYVLSSL  60
   61 MFANMKVLGV KDMSPILGEL KRVKSYMDKA KQYDNRITKS NEKSQAEQEK AKNIISNVLD 120
  121 GNKNQFEPSI SRSNFQGKHT KFENDELAES TTTKIIDSTD HIRKASSKKS KRLDKVGKKK 180
  181 GGKK

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) CSL4 DIS3 LRP1 MPP6 MTR3 RRP4 RRP40 RRP42 RRP43 RRP45 RRP46 RRP6 SKI6 SKI7
    View Details Krogan NJ, et al. (2006) CSL4 DDI1 DIS3 ENT3 LRP1 MPP6 MTR3 OSM1 RRP4 RRP40 RRP42 RRP43 RRP45 RRP46 RRP6 SKI6 SKI7 YBL055C
    View Details Gavin AC, et al. (2002) CSL4 DIS3 ECM16 LRP1 MTR3 RRP4 RRP40 RRP42 RRP43 RRP45 RRP46 RRP6 SKI2 SKI3 SKI6 SKI7 SRP1 UTP10 UTP20 UTP22 YIR035C

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


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    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..184] deduced N/A No confident structure predictions are available.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.97

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle